The Genetic Association Identified Between Intervertebral Disc Degeneration and Associated Risk Factors Based on a Systems Biology Approach

The intervertebral disc degeneration (IDD) with increasing aging mainly manifests as low back pain (LBP) accompanied with a loss of physical ability. These pathological processes can be preliminarily interpreted as a series of changes at cellular level. In addition to cell death, disc cells enter into the stagnation with dysfunction and deteriorate tissue microenvironment in degenerative discs, which is recognized as cell senescence. During aging, many intrinsic and extrinsic factors have been proved to have strong connections with these cellular senescence phenomena. Growing evidences of these connections require us to gather up critical cues from potential risk factors to pathogenesis and relative interventions for retarding cell senescence and attenuating degenerative changes. In this paper, we try to clarify another important cell state apart from cell death in IDD and discuss senescence-associated changes in cells and extracellular microenvironment. Then, we emphasize the role of oxidative stress and epigenomic perturbations in linking risk factors to cell senescence in the onset of IDD. Further, we summarize the current interventions targeting senescent cells that may exert the benefits of antidegeneration in IDD.

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Association of Lower Lumbar Facet Joint Osteoarthritis With Demographic Factors And Intervertebral Disc Degeneration In Patients With Low Back Pain

European Journal of Medical and Health Sciences ◽

10.24018/ejmed.2020.2.2.206 ◽

2020 ◽

Vol 2 (2) ◽

Author(s):

Haider Al-Tameemi ◽

Farah Hikmet Majid

Keyword(s):

Risk Factors ◽

Low Back Pain ◽

Back Pain ◽

Intervertebral Disc ◽

Disc Degeneration ◽

Intervertebral Disc Degeneration ◽

Facet Joint ◽

P Value ◽

Low Back ◽

Facet Joint Osteoarthritis

Background: Facet joint osteoarthritis (FJO) is an important element of lumbosacral degenerative disease. However, its association with other possible risk factors is still controversial. This study was conducted to investigate the association of FJO with risk factors and with presence of lumbar intervertebral disc degeneration (IVDD). Patient and method: Lumbosacral magnetic resonance imaging (MRI) examinations of 100 patients (36 male and 64 female) with low back pain (LBP) were reviewed in this cross-sectional retrospective study for the presence of FJO. The overall prevalence of FJO as well as the number of levels affected was correlated with the age, gender, body weight, height, BMI, female parity. FJO was also correlated with presence of corresponding IVDD. Results: Overall prevalence of FJO was 23%. The prevalence of FJO was significantly associated with advancing age (p=0.018). Females were more affected than males but without statistical significance (p value = 0.79). Similarly, FJO were more frequent in women with advanced multiparity but the association was statistically not significant (p value 0.1) there was statistically significant association between BMI and number of levels affected by FJO (p value 0.037). IVDD was significantly associated with higher prevalence of FJO especially at L3/4 and L4/5 levels (p values P<0.0001 and 0.04 respectively). Conclusion: Age was the single most important factor significantly associated with both overall higher prevalence of FJO and higher number of involved levels. BMI was statistically associated with increasing number of level affected. IVDD was significantly associated with presence of FJO at L3/4 & L4/5 levels.

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Interplay between Genetic Risk Factors and Protective Mechanisms for Intervertebral Disc Degeneration in Mice

Global Spine Journal ◽

10.1055/s-0035-1554500 ◽

2015 ◽

Vol 5 (1_suppl) ◽

pp. s-0035-1554500-s-0035-1554500

Author(s):

Ming Shum Yip ◽

K. S. Lee ◽

To Kam Lam ◽

Kenneth M. C. Cheung ◽

Kathryn S. E. Cheah ◽

...

Keyword(s):

Risk Factors ◽

Intervertebral Disc ◽

Disc Degeneration ◽

Genetic Risk ◽

Intervertebral Disc Degeneration ◽

Genetic Risk Factors ◽

Protective Mechanisms

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Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2017.01.001 ◽

2017 ◽

Vol 25 (7) ◽

pp. 1122-1131 ◽

Cited By ~ 30

Author(s):

M. Teraguchi ◽

N. Yoshimura ◽

H. Hashizume ◽

H. Yamada ◽

H. Oka ◽

...

Keyword(s):

Risk Factors ◽

Intervertebral Disc ◽

Disc Degeneration ◽

Intervertebral Disc Degeneration ◽

Population Based

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Faculty Opinions recommendation of Novel function of TWEAK in inducing intervertebral disc degeneration.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1095070.550070 ◽

2007 ◽

Author(s):

Helen Gruber

Keyword(s):

Intervertebral Disc ◽

Disc Degeneration ◽

Intervertebral Disc Degeneration

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INTERVERTEBRAL DISC DEGENERATION LINKED TO STRUCTURAL GENE VARIATIONS

Pakistan Journal of Medicine and Dentistry ◽

10.36283/pjmd8-4/012 ◽

2019 ◽

Author(s):

Saeeda Baig

Keyword(s):

Intervertebral Disc ◽

Disc Degeneration ◽

Intervertebral Disc Degeneration ◽

English Language ◽

Tandem Repeats ◽

Lumbar Disc ◽

Disease Process ◽

Nucleotide Polymorphisms ◽

Structural Protein ◽

Lumbar Disc Degeneration

During the recent past focus has shifted from identifying intervertebral disc degeneration as being caused by physical exposure and strain to being linked with a variety of genetic variations. The objective of this review is to provide an up to date review of the existing research data regarding the relation of intervertebral disc degeneration to structural protein genes and their polymorphisms and thus help clearly establish further avenues where research into causation and treatment is needed. A comprehensive search using the keywords “Collagen”, “COL”, “Aggrecan”, “AGC”, “IVDD”, “intervertebral disc degeneration”, and “lumbar disc degeneration” from PubMed and Google Scholar, where literature in the English language was selected spanning from 1991 to 2019. There are many genes involved in the production of structural components of an intervertebral disc. The issues in production of these components involve the over-expression or under-expression of their genes, and single nucleotide polymorphisms and variable number of tandem repeats affecting their structures. These structural genes include primarily the collagen and the aggrecan genes. While genetic and environmental factors all come into play with a disease process like disc degeneration, the bulk of research now shows the significantly larger impact of hereditary over exposure. While further research is needed into some of the lesser studied genes linked to IVDD and also the racial variations in genetic makeup, the focus in the near future should be on establishment of genetic testing to identify individuals at greater risk of disease and deliberation regarding the use of gene therapy to prevent disc degeneration.

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