Activated protein C improves lipopolysaccharide-induced cardiovascular dysfunction by decreasing tissular inflammation and oxidative stress*

2009 ◽  
Vol 37 (1) ◽  
pp. 246-255 ◽  
Author(s):  
Sennoun Nacira ◽  
Ferhat Meziani ◽  
Olivier Dessebe ◽  
Valérie Cattan ◽  
Solène Collin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein C ◽  
Activated Protein C ◽  
Cardiovascular Dysfunction ◽  
And Oxidative Stress

scholarly journals Developmental Programming of Cardiovascular Dysfunction by Prenatal Hypoxia and Oxidative Stress

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e31017 ◽  
Author(s):  
Dino A. Giussani ◽  
Emily J. Camm ◽  
Youguo Niu ◽  
Hans G. Richter ◽  
Carlos E. Blanco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Developmental Programming ◽  
Prenatal Hypoxia ◽  
Cardiovascular Dysfunction ◽  
And Oxidative Stress

Serum concentration of procoagulant, endothelial and oxidative stress markers in early primary varicose veins

2008 ◽  
Vol 23 (1) ◽  
pp. 15-20 ◽  
Author(s):  
A Yasim ◽  
M Kilinç ◽  
M Aral ◽  
H Oksuz ◽  
M Kabalci ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein C ◽  
Varicose Veins ◽  
Protein S ◽  
Endothelial Damage ◽  
Control Group ◽  
Study Group ◽  
Vascular Endothelial ◽  
Primary Varicose Veins ◽  
And Oxidative Stress

Objective Endothelial disorders of the veins are considered to play a role in the pathogenesis of primary varicose veins and oxidative stress is implicated in these disorders. With this aim, we investigated vascular endothelial marker levels and the effect of endothelial damage on coagulation parameters and vasodilator substances to determine metabolic markers of oxidative stress in patients with varicose veins and vascular endothelial damage caused by oxidative stress. Methods We investigated the levels of malondialdehyde (MDA), protein C, protein S, fibrinogen, von Willebrand factor (vWf), tissue plasminogen activator (tPA), vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), interleukin-12 (IL-12) and nitric oxide (NO) in the blood taken from the brachial vein of 25 patients with primary varicose veins (study group) and compared the results with 25 healthy volunteers (control group). We also investigated the urinary levels of prostaglandin I2 (PGI2) in the study group and compared the results with the control group. Results There was no statistically significant difference between the study group and the control group with respect to the plasma levels of MDA, protein C, fibrinogen, tPA, IL-6, NO and urinary levels of PGI2. But plasma levels of protein S, vWf, VEGF and IL-12 were found to be statistically significantly higher in the study group than in the control group. Conclusions Although the systemically measured levels of protein S, vWf, VEGF and IL-12 were found to be higher in patients of primary varicose veins, levels of protein C, fibrinogen, homocysteine and PGI2 were not found to be statistically significant. No systemic increased oxidative stress seems to be related to the early stages of chronic venous insufficiency. Further studies are warranted for understanding the role of molecules such as NO, oxidative stress parameters and cytokines.

Activated protein C: the cure for sepsis - again?

Anaesthesia ◽  
2001 ◽  
Vol 56 (12) ◽  
pp. 1133-1135 ◽  
Author(s):  
Tariq Hoth ◽  
Timothy W. Evans
Keyword(s):  
Protein C ◽  
Activated Protein C

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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