Cesarean section does not affect neonatal outcomes of pregnancies complicated with preterm premature rupture of membranes

Inflammation is associated with preterm premature rupture of membranes (PPROM) and adverse neonatal outcomes. Subchorionic thrombi, with or without inflammation, may also be a significant pathological finding in PPROM. Patterns of inflammation and thrombosis may give insight into mechanisms of adverse neonatal outcomes associated with PPROM. To characterize histologic findings of placentas from pregnancies complicated by PPROM at altitude, 44 placentas were evaluated for gross and histological indicators of inflammation and thrombosis. Student's t-test (or Mann–Whitney U-test), χ2 analysis (or Fisher's exact test), mean square contingency and logistic regression were used when appropriate. The prevalence of histologic acute chorioamnionitis (HCA) was 59%. Fetal-derived inflammation (funisitis and chorionic plate vasculitis) was seen at lower frequency (30% and 45%, respectively) and not always in association with HCA. There was a trend for Hispanic women to have higher odds of funisitis (OR = 5.9; P = 0.05). Subchorionic thrombi were seen in 34% of all placentas. The odds of subchorionic thrombi without HCA was 6.3 times greater that the odds of subchorionic thrombi with HCA (P = 0.02). There was no difference in gestational age or rupture-to-delivery interval, with the presence or absence of inflammatory or thrombotic lesions. These findings suggest that PPROM is caused by or can result in fetal inflammation, placental malperfusion, or both, independent of gestational age or rupture-to-delivery interval; maternal ethnicity and altitude may contribute to these findings. Future studies focused on this constellation of PPROM placental findings, genetic polymorphisms and neonatal outcomes are needed.

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Neonatal outcomes of preterm premature rupture of membranes at 32-36 weeks gestation improve with increasing gestational age at time of delivery

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2006.10.693 ◽

2006 ◽

Vol 195 (6) ◽

pp. S193

Author(s):

Natali Aziz ◽

Larry Rand ◽

Yvonne Cheng ◽

Enrique Soto ◽

Aaron Caughey

Keyword(s):

Gestational Age ◽

Neonatal Outcomes ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture

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182 Cases of Premature Rupture of Membranes and Treatment Strategy Analysis

Advanced Emergency Medicine ◽

10.18686/aem.v4i4.8 ◽

2015 ◽

Vol 4 (4) ◽

pp. 23

Author(s):

Wenxian Dai

Keyword(s):

Risk Factors ◽

Survival Rate ◽

Cesarean Section ◽

Treatment Strategy ◽

Treatment Strategies ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Strategy Analysis ◽

Related Factors ◽

Preterm Premature Rupture

Objective: Related factors and treatment strategies of premature rupture of membranes (PROM) were discussed. Method: Retrospective analysis of 182 cases of preterm premature rupture of membranes (PPROM) from Yanshan County Hospital from January 2010 to October 2015. Results: From the 182 cases [123 vaginal delivery and 59 cesarean section (C-section)], there were 79.12% PROM cases were detected in the presence of risk factors. Neonatal mortality and complications were significantly higher at 28−33 + 6 weeks of pregnancy than those at 34−36 + 6 weeks, 28−33 + 6 weeks, and 34−36 + 6 weeks. Conclusion: In order to improve the survival rate of newborns, the related factors leading to PPROM should be treated.

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To Evaluate Maternal Platelet Indices in Preterm Premature Rupture of Membranes and Their Relation with Adverse Neonatal Outcomes

Scholars International Journal of Obstetrics and Gynecology ◽

10.36348/sijog.2020.v03i03.008 ◽

2020 ◽

Vol 03 (03) ◽

pp. 98-105

Author(s):

Dr. Urmila Kumari ◽

Dr. Kavita Choudhary ◽

Dr. Premlata Mital ◽

Dr. Jeetendra Singh ◽

Dr. Ankita Choudhary ◽

...

Keyword(s):

Neonatal Outcomes ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Platelet Indices ◽

Preterm Premature Rupture ◽

Adverse Neonatal Outcomes

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Respiratory Distress Syndrome in Infants Delivered via Cesarean from Mothers with Preterm Premature Rupture of Membranes: A Propensity Score Analysis

Journal of Pregnancy ◽

10.1155/2020/5658327 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Mariko Nakahara ◽

Shunji Goto ◽

Eiji Kato ◽

Atsuo Itakura ◽

Satoru Takeda

Keyword(s):

Mechanical Ventilation ◽

Propensity Score ◽

Cesarean Section ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture ◽

Cesarean Deliveries

Objective. This study aimed to clarify the effects of cesarean delivery on neonatal respiratory morbidity when women had preterm premature rupture of membranes. Methods. This retrospective study included women with preterm premature rupture of membranes who delivered from 23 weeks to 33 weeks of gestation between January 2009 and December 2014. Neonatal outcomes were compared between infants delivered by cesarean section and those delivered vaginally. The primary outcome was respiratory distress syndrome (RDS). Neonatal intubation and mechanical ventilation periods were secondary outcomes. Propensity score matching was used to compare outcomes between cesarean and vaginal delivery cases. Results. There were 101 cesarean deliveries and 89 vaginal deliveries. A comparison of the presence or absence of neonatal complications based on the delivery type indicated a higher occurrence of RDS with cesarean deliveries (P=0.025). The intubation and mechanical ventilation periods were not significantly longer in neonates delivered via cesarean section. Conclusions. Cesarean delivery is a risk factor for neonatal RDS in women with preterm premature rupture of membranes. Trials identifying long-term neonatal prognoses are needed to further develop optimal management strategies in such cases.

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Maternal and Neonatal Outcomes of Preterm Premature Rupture of Membranes before Viability

Klinische Pädiatrie ◽

10.1055/s-0041-111174 ◽

2016 ◽

Vol 228 (02) ◽

pp. 69-76 ◽

Cited By ~ 2

Author(s):

I. van der Marel ◽

R. de Jonge ◽

J. Duvekot ◽

I. Reiss ◽

I. Brussé

Keyword(s):

Neonatal Outcomes ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture ◽

Maternal And Neonatal Outcomes

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Differences in neonatal outcomes according to the stage of acute chorioamnionitis and funisitis in preterm premature rupture of membranes

Placenta ◽

10.1016/j.placenta.2013.06.171 ◽

2013 ◽

Vol 34 (9) ◽

pp. A57

Author(s):

Hyun-joo Kim ◽

Yeri Lee ◽

Suk-Joo Choi ◽

Soo-young Oh ◽

Jung-Sun Kim ◽

...

Keyword(s):

Neonatal Outcomes ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture

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Evaluation of maternal and neonatal outcomes in the case of preterm premature rupture of membranes and their relationship to prenatal maternal indicators: Across -sectional descriptive study

Journal of Nursing Education and Practice ◽

10.5430/jnep.v10n6p55 ◽

2020 ◽

Vol 10 (6) ◽

pp. 55

Author(s):

Mirfat Mohamed Labib El-Kashif ◽

Azza Mohamed Fathy ◽

Howaida Amin Hassan Fahmy Elsaba

Keyword(s):

Neonatal Outcome ◽

Expectant Management ◽

Neonatal Outcomes ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Singleton Pregnancy ◽

Cross Sectional ◽

Preterm Premature Rupture ◽

Management Protocol ◽

Maternal And Neonatal Outcomes

Background and aim: Preterm premature rupture of membranes is one of the most important causes of pregnancy complication and a significant role in the occurrence of perinatal morbidity and mortality. The present study aims to evaluate the maternal and neonatal outcomes in the case of preterm premature rupture of membranes and their relationship to prenatal maternal indicators.Subjects and methods: A cross-sectional descriptive design was used to evaluate 68 pregnant women with a gestational age of 32 to before 37 weeks, and singleton pregnancy complicated by preterm premature rupture of membranes who fulfilled the inclusion criteria. The data were collected by convenience sampling using standardized tools.Results: A linear correlation was used to show a correlation between maternal clinical indicators with the predictive maternal and neonatal outcome using a Spearman Rho correlation coefficient. The most significant neonatal outcomes are neonatal intensive care unit admission, neonatal respiratory distress syndrome, and early neonatal sepsis. More than two-thirds of the studied women had expectant management, and less than one-fourth of them have postnatal sepsis.Conclusion and recommendation: The prenatal maternal indicators are the significant values for maternal and neonatal outcome in case of preterm premature rupture of membranes, so A further larger prospective study is recommended to demonstrate the difference in incidence, management protocol of preterm premature rupture of the membranes in the delivery and maternity health care services.

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