scholarly journals Modafinil and γ-hydroxybutyrate have sleep state-specific pharmacological actions on hypocretin-1 physiology in a primate model of human sleep

2009 ◽  
Vol 20 (7) ◽  
pp. 643-652 ◽  
Author(s):  
Jamie M. Zeitzer ◽  
Christine L. Buckmaster ◽  
Hans-Peter Landolt ◽  
David M. Lyons ◽  
Emmanuel Mignot
Keyword(s):  
Sleep State ◽  
Primate Model ◽  
Human Sleep ◽  
Hypocretin 1

Biological Rhythm Based Wearable Sleep State Observer

2007 ◽  
Vol 11 (2) ◽  
pp. 232-241 ◽  
Author(s):  
Yuki Wakuda ◽  
◽  
Akiko Noda ◽  
Yasuhisa Hasegawa ◽  
Fumihito Arai ◽  
...  
Keyword(s):  
Sleep Stage ◽  
Biological Rhythm ◽  
Sleep Cycle ◽  
Stress System ◽  
Sleep State ◽  
Human Sleep ◽  
Sensor Device ◽  
Preset Time ◽  
Pulse Waves ◽  
Life Cycle Pattern

This research aimed to observe human biological rhythm and adjust the human sleep wake pattern based on controlling wakeup timing using low stress system. An ordinary alarm clock operates according to preset time. Biological rhythm determines the human sleep cycle, which affects sleep depth and wakeup timing, which in turn resets the daily rhythm that affects human’s behavior, life-cycle pattern, life-style related disease. We developed a wearable biological rhythm based awakening controller (BRAC) that determines the biological rhythm in the sleep state (sleep cycle) and stimulates the user at a suitable time to enable the person to wakeup refreshed. The proposed system BRAC gauges human’s sleep quality and rhythms from peak to peak interval time of fingertip-pulse waves, that are measured more easily than polysomnography (PSG). In this paper, we detail the method of sleep cycle estimation using a wearable sensor device as the first feature of BRAC, then, in experiments, evaluate the performance of sleep cycle estimation based on a comparison of the BRAC-sleep cycle and the PSG-determined sleep stage.

Hexachlorobenzene toxicity in the monkey ovary: III. Ultrastructure induced by high (10 mg/kg) dose exposure

1991 ◽  
Vol 49 ◽  
pp. 130-131
Author(s):  
A. Singh ◽  
A. Dykeman ◽  
J. Jarrelf ◽  
D. C. Villeneuve
Keyword(s):  
Present Report ◽  
Reproductive Toxicity ◽  
Control Group ◽  
Primate Model ◽  
Human Follicular Fluid ◽  
Thin Sections ◽  
Cynomolgus Monkeys ◽  
Cacodylate Buffer ◽  
Induction Cycle ◽  
Comprehensive Study

Hexachlorobenzene (HCB), a persistent and mobile organochlorine pesticide, occurs in environment. HCB has been shown to be present in human follicular fluid. An objective of the present report, which is part of a comprehensive study on reproductive toxicity of HCB, was to determine the cytologic effects of the compound on ovarian follicles in a primate model.Materials and Methods. Eight Cynomolgus monkeys were housed under controlled conditions at Animal facility of Health and Welfare, Ottawa. Animals were orally administered gelatin capsules containing HCB mixed with glucose in daily dosages of 0.0 or 10 mg/kg b.w. for 90 days; the former was the control group. On the menstrual period following completion of dosing, the monkeys underwent an induction cycle of superovulation. At necropsy, one-half of an ovary from each animal was diced into ca. 2- to 3-mm cubed specimens that were fixed by immersion in 2.5% glutaraldehyde in 0.1 M cacodylate buffer (pH 7.3). Subsequent procedures followed to obtain thin sections that were examined in a Hitachi H-7000 electron microscope have been described earlier.

Changes in the CEA gene are a basis for the lack of hepatic metastases in a spontaneous colorectal cancer primate model

2001 ◽  
Vol 120 (5) ◽  
pp. A167-A167
Author(s):  
R ZIMMER ◽  
P THOMAS ◽  
N CLAPP ◽  
C STANNERS ◽  
M TOBI ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hepatic Metastases ◽  
Primate Model ◽  
Cea Gene

Methods for assessing human sleep

1971 ◽  
Vol 127 (3) ◽  
pp. 484a-492
Author(s):  
M. W. Johns
Keyword(s):  
Human Sleep

Maternal High-Fat Diet Persistently Alters Bone Marrow Immune Cell Proportions and Function in a Nonhuman Primate Model

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 222-OR
Author(s):  
MICHAEL J. NASH ◽  
TAYLOR K. SODERBORG ◽  
RACHEL C. JANSSEN ◽  
ERIC M. PIETRAS ◽  
JACOB E. FRIEDMAN
Keyword(s):  
Bone Marrow ◽  
Nonhuman Primate ◽  
High Fat Diet ◽  
Immune Cell ◽  
High Fat ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
And Function

Functional stereotactic radiosurgery involving a dedicated linear accelerator and gamma unit: a comparison study

2004 ◽  
pp. 373-380 ◽  
Author(s):  
Timothy D. Solberg ◽  
Steven J. Goetsch ◽  
Michael T. Selch ◽  
William Melega ◽  
Goran Lacan ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Linear Accelerator ◽  
Treatment Plan ◽  
Single Shot ◽  
Submillimeter Range ◽  
Primate Model ◽  
Content Type ◽  
Stereotactic Frame ◽  
Targeting Ability ◽  
Fine Print

Object. The purpose of this work was to investigate the targeting and dosimetric characteristics of a linear accelerator (LINAC) system dedicated for stereotactic radiosurgery compared with those of a commercial gamma knife (GK) unit. Methods. A phantom was rigidly affixed within a Leksell stereotactic frame and axial computerized tomography scans were obtained using an appropriate stereotactic localization device. Treatment plans were performed, film was inserted into a recessed area, and the phantom was positioned and treated according to each treatment plan. In the case of the LINAC system, four 140° arcs, spanning ± 60° of couch rotation, were used. In the case of the GK unit, all 201 sources were left unplugged. Radiation was delivered using 3- and 8-mm LINAC collimators and 4- and 8-mm collimators of the GK unit. Targeting ability was investigated independently on the dedicated LINAC by using a primate model. Measured 50% spot widths for multisource, single-shot radiation exceeded nominal values in all cases by 38 to 70% for the GK unit and 11 to 33% for the LINAC system. Measured offsets were indicative of submillimeter targeting precision on both devices. In primate studies, the appearance of an magnetic resonance imaging—enhancing lesion coincided with the intended target. Conclusions. Radiosurgery performed using the 3-mm collimator of the dedicated LINAC exhibited characteristics that compared favorably with those of a dedicated GK unit. Overall targeting accuracy in the submillimeter range can be achieved, and dose distributions with sharp falloff can be expected for both devices.

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