Altered Biological Rhythm and Alzheimer's Disease: A Bidirectional Relationship

: Biological rhythms have become the research focus in recent years. Biological rhythm disruption is a common symptom of Alzheimer's disease (AD) patients, which is usually consid- ered as the late consequence of AD. Recent studies have shown that biological rhythm disruption even occurs before the onset of clinical symptoms of AD. The causal relationship between AD and biological rhythm disruption is not clear. Delineating their relationship can help understand the dis- ease mechanisms and make the early diagnosis of AD possible. This review integrates the research on the abnormal changes of the biological rhythm-related parameters in the clinical manifestations of AD patients and the roles of the biological rhythm disorders in AD. We will discuss the links be- tween biological rhythms and AD, with the focus on the bidirectionality between biological rhythms and AD processes. Collectively, these updated research findings may provide the basis for further exploring the significance of rhythm in the diagnosis and treatment of AD.

FEASIBILITY STUDY OF HUMAN BIORHYTHM TO IMPROVE SPORTS TRAINING INJURY

ABSTRACT Introduction: Sports injury often occurs in sports teaching and training, which directly affects the performance of the human body function and the improvement of sports performance. Objective: To study the feasibility of improving the biorhythm in sports training injury. Methods: 120 young athletes who are engaged in track and field training in traditional track and field sports schools in Liaoning Province are taken as the research objects. The effective data of the time and types of sports injuries, and the birth date, month and date of the injured athletes during training from 2005 to 2006 were collected. Results: Results show that in the relationship between human body three rhythm and the athlete's sports injury, the probability of sports injury in triple height is smaller; regarding the biological rhythm in one or more than one period or critical period, the damage probability is 95%, showing that most athletes sports injuries occur at a low and critical period stage. Conclusions: The arrangement of sports training must be adapted to the original biological rhythm of the human body, and the corresponding monthly cycle training plan should be made according to changes that occur in athletes’ physical cycles to avoid injury during training. Level of evidence II; Therapeutic studies - investigation of treatment results.

Diversity of biological rhythm and food web stability

How ecosystem biodiversity is maintained remains a persistent question in the field of ecology. Here, I present a new coexistence theory, i.e. diversity of biological rhythm. Circadian, circalunar and circannual rhythms, which control short- and long-term activities, are identified as universal phenomena in organisms. Analysis of a theoretical food web with diel, monthly and annual cycles in foraging activity for each organism shows that diverse biological cycles play key roles in maintaining complex communities. Each biological rhythm does not have a strong stabilizing effect independently but enhances community persistence when combined with other rhythms. Biological rhythms also mitigate inherent destabilization tendencies caused by food web complexity. Temporal weak interactions due to hybridity of multiple activity cycles play a key role toward coexistence. Polyrhythmic changes in biological activities in response to the Earth's rotation may be a key factor in maintaining biological communities.

Lentinan Inhibited the Activation of Th2 Cells in Allergic Mice by Reducing the Amplitude of Changes in Biological Rhythm

<b><i>Introduction:</i></b> Biological rhythm is inextricably linked to the physiological mechanisms of allergic diseases, but the exact mechanisms are still poorly understood. Clinical studies have reported rhythmic fluctuations in allergic diseases. The search for natural and harmless active ingredients based on biological rhythm with which to regulate allergic diseases is essential for the control of food allergy. <b><i>Methods:</i></b> In this study, mice were treated at different time points to determine the link between the severity of allergic reactions and the circadian clock genes. The mice were treated with lentinan, either continuously or discontinuously, to assess their clinical symptoms, vascular permeability, immune cells, cytokines, and clock genes. Specifically, rat basophilic leukemia (RBL-2H3) cells were treated with lentinan and the rhythmic changes of cell degranulation were measured. <b><i>Results:</i></b> The results in different models showed that the allergic reactions in mice treated at different time points were significantly different and thus related to fluctuations in biological rhythm. Treatment with lentinan was found to reduce the amplitude of changes in the clock genes, such as the activation of Per and Cry proteins in allergic mice, as well as to regulate biological rhythm in cells, inhibit the activation of Th2 cells, and alleviate allergic reactions. Furthermore, lentinan changed the rhythm of degranulation in RBL-2H3 cells. <b><i>Conclusion:</i></b> Lentinan was, therefore, determined to successfully alleviate allergic reactions by reducing the amplitude of changes in the body’s biological rhythm, inhibiting the activation of Th2 cells, and affecting the immune microenvironment.

MATRA BASTI THE PANACEA: A NARRATIVE REVIEW

In Panchakarma, Basti is one of the important therapies. Basti Chikitsa (therapeutic enema) is a natural method to detoxify the body and putting the vivacity into the millions of processes proceeding in the body i.e. it has the power to change the biological rhythm of the body and encourages self-healing. The impuri-ties which are entangled with the body are scraped by the Basti Karma and shown the path of egress to them. It is a holistic treatment with natural things to bring the body back into its natural and homoeostatic state. Basti Chikitsa is considered to be a prime treatment modality among the Panchakarma in Ayurveda. It has not only curative aspects but also preventive and promotive aspects. This Basti treatment also relieves stress from the body and mind to improve the quality of life. Matra Basti is a therapy where least dose of oil/unctuous substance is used. It is preceded by abhyanga (therapeutic oil massage) and Swedana (suda-tion). Human is the king of the castle (body) so he has to make the decisions how to convert it into more beautiful and healthy state along with its prevention from the rust of impurities.