Effects of long-term tibolone treatment on nuclear sex steroid hormone receptors and G-protein–coupled estrogen receptor-1 expression in the macaque uterus

2012 ◽  
Vol 19 (3) ◽  
pp. 332-338 ◽  
Author(s):  
Mariana Hulchiy ◽  
Hua Zhang ◽  
J. Mark Cline ◽  
Angelica Lindén Hirschberg ◽  
Lena Sahlin
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Sex Steroid ◽  
Sex Steroid Hormone ◽  
G Protein Coupled ◽  
Estrogen Receptor 1

Pelvic floor sex steroid hormone receptors, distribution and expression in pre- and postmenopausal stress urinary incontinent women

2007 ◽  
Vol 86 (11) ◽  
pp. 1377-1384 ◽  
Author(s):  
Marie Westergren Söderberg ◽  
Bengt Johansson ◽  
Britt Masironi ◽  
Birgitta Byström ◽  
Christian Falconer ◽  
...  
Keyword(s):  
Pelvic Floor ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Sex Steroid ◽  
Sex Steroid Hormone

Immunolocalization of sex steroid hormone receptors in the canine uterine tube and their relation to sex steroid hormone levels

2002 ◽  
Vol 14 (4) ◽  
pp. 241 ◽  
Author(s):  
Hilde Vermeirsch ◽  
Wim Van Den Broeck ◽  
Mark Coryn ◽  
Paul Simoens
Keyword(s):  
Epithelial Cells ◽  
Estrous Cycle ◽  
Stromal Cells ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Sex Steroid ◽  
Nuclear Staining ◽  
Sex Steroid Hormone ◽  
Uterine Tube

The aim of this immunohistochemical study was to describe the cellular distribution of the estrogen receptor-α (ERα), progesterone receptor (PR) and androgen receptor (AR) in canine uterine tubes. Samples of uterine tubes were taken from dogs in different stages of the estrous cycle, and dogs that were pregnant or had just delivered. Nuclear staining for sex steroid hormone receptors was observed in the surface epithelium, stromal cells and smooth muscle cells of the muscular layer. Only slight differences in staining pattern were observed between the ampulla and fimbriae. The staining for ERα and PR showed changes throughout the estrous cycle. Some of these changes were related to changing concentrations of sex steroid hormones. High staining scores for ERα and PR were found during proestrus and low scores during early metestrus. The staining for AR showed only minor cyclic changes. However, during proestrus and estrus, cytoplasmic staining for AR was observed in differentiated secretory epithelial cells, when nuclear staining in these cells was nearly absent. For the three hormone receptors, stromal cells generally stained with a higher intensity than epithelial cells. It is likely that many steroid hormone actions on the epithelium are mediated through stromal cells. During pregnancy, rather high staining scores were found for ERα and AR in the uterine tube. This is in contrast to observations in the canine pregnant uterus.

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