Defining the Concomitant Multiple Organ Injury within the ARS and DEARE in an Animal Model Research Platform

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Thomas J. MacVittie ◽  
Ann M. Farese
Keyword(s):  
Animal Model ◽  
Multiple Organ ◽  
Organ Injury ◽  
Model Research ◽  
Research Platform ◽  
Multiple Organ Injury

The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock

2001 ◽  
Vol 29 (8) ◽  
pp. 1599-1608 ◽  
Author(s):  
Kai Zacharowski ◽  
Reinhard Berkels ◽  
Antje Olbrich ◽  
Prabal K. Chatterjee ◽  
Salvatore Cuzzocrea ◽  
...  
Keyword(s):  
Guanylate Cyclase ◽  
Multiple Organ ◽  
Organ Injury ◽  
Rodent Models ◽  
Gram Positive ◽  
Gram Negative ◽  
Multiple Organ Injury ◽  
Negative Shock

scholarly journals Ubiquitin-Specific Protease 25 Aggravates Acute Pancreatitis and Acute Pancreatitis-Related Multiple Organ Injury by Destroying Tight Junctions Through Activation of The STAT3 Pathway

2022 ◽  
Vol 9 ◽  
Author(s):  
Zhengru Liu ◽  
Mingming Qi ◽  
Shan Tian ◽  
Qian Yang ◽  
Jian Liu ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Tight Junctions ◽  
Multiple Organ ◽  
Organ Injury ◽  
Pancreatic Acinar Cells ◽  
Stat3 Pathway ◽  
Specific Protease ◽  
Ubiquitin Specific Protease ◽  
Multiple Organ Injury

Ubiquitin-specific protease 25 (USP25) plays an important role in inflammation and immunity. However, the role of USP25 in acute pancreatitis (AP) is still unclear. To evaluate the role of USP25 in AP, we conducted research on clinical AP patients, USP25wild-type(WT)/USP25 knockout (USP25−/−) mice, and pancreatic acinar cells. Our results showed that serum USP25 concentration was higher in AP patients than in healthy controls and was positively correlated with disease severity. AP patients’ serum USP25 levels after treatment were significantly lower than that at the onset of AP. Moreover, USP25 expression was upregulated in cerulein-induced AP in mice, while USP25 deficiency attenuates AP and AP-related multiple organ injury. In vivo and in vitro studies showed that USP25 exacerbates AP by promoting the release of pro-inflammatory factors and destroying tight junctions of the pancreas. We showed that USP25 aggravates AP and AP-related multiple organ injury by activating the signal transducer and activator of transcription 3 (STAT3) pathway. Targeting the action of USP25 may present a potential therapeutic option for treating AP.

ATTENUATION OF ENDOTOXIN-INDUCED OXIDATIVE STRESS AND MULTIPLE ORGAN INJURY BY 3,4-METHYLENEDIOXYPHENOL IN RATS

Shock ◽  
2006 ◽  
Vol 25 (3) ◽  
pp. 300-305 ◽  
Author(s):  
Dur-Zong Hsu ◽  
Ya-Hui Li ◽  
Pei-Yi Chu ◽  
Se-Ping Chien ◽  
Yin-Ching Chuang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Organ ◽  
Organ Injury ◽  
Multiple Organ Injury

Co-exposure of lipopolysaccharide andpseudomonas aeruginosaexotoxin A-induced multiple organ injury in rats

2009 ◽  
Vol 31 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Chien-Chao Chiu ◽  
Yen-Te Huang ◽  
Hsiao-Li Chuang ◽  
Hans Hsien-Chuan Chen ◽  
Tung-Ching Chung
Keyword(s):  
Multiple Organ ◽  
Organ Injury ◽  
Multiple Organ Injury

ARS, Deare, and Multiple-Organ Injury

2019 ◽  
pp. 1
Author(s):  
Thomas J. MacVittie ◽  
Ann M. Farese ◽  
Maureen A. Kane
Keyword(s):  
Multiple Organ ◽  
Organ Injury ◽  
Multiple Organ Injury
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