Bulky Early-Stage Cervical Cancer (2-4 cm Lesions): Upfront Radical Trachelectomy or Neoadjuvant Chemotherapy Followed by Fertility-Preserving Surgery

2015 ◽  
Vol 25 (4) ◽  
pp. 722-728 ◽  
Author(s):  
Marie Plante
Keyword(s):  
Cervical Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Young Women ◽  
Early Stage ◽  
Oncologic Outcome ◽  
Radical Trachelectomy ◽  
Advantages And Disadvantages ◽  
Early Stage Cervical Cancer ◽  
Obstetrical Outcome ◽  
Few Data

AbstractRadical trachelectomy is now recognized as a valid treatment option for young women with early-stage cervical cancer with lesions measuring less than 2 cm. However, for women with bulky lesions measuring greater than 2cm, few data are available in the literature to guide management. There are currently 2 options available: either upfront radical trachelectomy or neoadjuvant chemotherapy followed by fertility-preserving surgery. Overall, both options offer very good oncologic outcome; however, the rate of fertility preservation and obstetrical outcome seem superior after neoadjuvant chemotherapy. Advantages and disadvantages of both options are discussed and a thorough literature review is provided. Issues to be further studied are also outlined.

scholarly journals Fertility-Sparing Surgery In Early Stage Cervical Cancer

2018 ◽  
Vol 12 (1) ◽  
pp. 37
Author(s):  
IN Gede Budiana ◽  
Tjokorda Gede Astawa Pemayun
Keyword(s):  
Cervical Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Early Stage ◽  
Reproductive Function ◽  
Reproductive Age ◽  
Radical Trachelectomy ◽  
Fertility Sparing Surgery ◽  
Younger Age ◽  
Fertility Sparing ◽  
Early Stage Cervical Cancer

Cervical cancer is a malignancy in women that cause major impacts, not only biologically, but also in various aspects of life. On patients during reproductive age, cervical cancer poses severe sexual and reproductive debilitation. Trend in the onset of first diagnosis is moving towards younger age, and mostly affect women in their reproductive age. This would give a bad impact on the sustainability of the patient’s reproductive function. Until now, fertilitysparing approach for the management of early-stage cervical cancer is still rare in Indonesia. However, some options of conservative surgical therapy are available for patients who desire fertility, namely conization, simple tracellectomy, radical trachelectomy, and also neoadjuvant chemotherapy. These options have been proven effective and safe, while maintaining patients’ reproductive functions. ABSTRAKKanker serviks merupakan suatu penyakit keganasan pada wanita yang memiliki dampak luas, tidak hanya pada tubuh penderita, namun juga berbagai aspek kehidupan penderita. Pada penderita di usia reproduktif, kanker serviks menimbulkan masalah seksual dan reproduksi yang berat bagi penderita. Kini usia dimana terjadinya kanker serviks mulai menunjukkan kecenderungan yang semakin muda yang tentunya memberikan dampak buruk terhadap keberlangsungan fungsi reproduksi pasien. Hingga saat ini, tatalaksana kanker serviks stadium awal dengan pendekatan fertility-sparing masih jarang dilakukan di Indonesia. Namun, beberapa pilihan terapi bedah konservatif tersedia bagi pasien yang menginginkan fertilitas, yakni konisasi, trakelektomi sederhana, trakelektomi radikal. hingga pemberian kemoterapi neo-adjuvant. Pilihan terapi ini telah terbukti efektif dan aman, serta mampu mem pertahankan fungsi reproduksi pasien.

Phẫu thuật bảo tồn khả năng sinh sản trong ung thư cổ tử cung giai đoạn sớm

2020 ◽  
Author(s):  
Lieu Ta Thanh
Keyword(s):  
Cervical Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Surgical Therapy ◽  
Early Stage ◽  
Reproductive Function ◽  
Reproductive Age ◽  
Radical Trachelectomy ◽  
Younger Age ◽  
Early Stage Cervical Cancer ◽  
First Diagnosis

Cervical cancer is a malignancy in women that cause major impacts, not only biologically, but also in various aspects of life. On patients during reproductive age, cervical cancer poses severe sexual and reproductive debilitation. Trend in the onset of first diagnosis is moving towards younger age, and mostly affect women in their reproductive age. This would give a bad impact on the sustainability of the patient’s reproductive function. Until now, fertilitysparing approach for the management of early-stage cervical cancer is still rare in VietNam.However, some options of conservative surgical therapy are available for patients who desire fertility, namely conization, simple tracellectomy, radical trachelectomy, and also neoadjuvant chemotherapy. These options have been proven effective and safe, while maintaining patients’ reproductive functions

Radical Trachelectomy Performed During Pregnancy: A Review of the Literature

2016 ◽  
Vol 26 (4) ◽  
pp. 758-762 ◽  
Author(s):  
Mihai Emil Căpîlna ◽  
Belá Szabo ◽  
Janos Becsi ◽  
Nicolae Ioanid ◽  
Bogdan Moldovan
Keyword(s):  
Cervical Cancer ◽  
Young Women ◽  
Early Stage ◽  
Invasive Cervical Cancer ◽  
Review Of The Literature ◽  
Ongoing Pregnancy ◽  
Vaginal Route ◽  
Radical Trachelectomy ◽  
Medline Search ◽  
Early Stage Cervical Cancer

ObjectiveCervical cancer is one of the most frequent malignant diseases diagnosed during pregnancy. Abdominal or vaginal radical trachelectomies are fertility-preserving alternatives to radical hysterectomy for young women with early-stage cervical cancer that can be performed during ongoing pregnancy.MethodsA literature review of articles on this subject was conducted through a Medline search for articles published in English or French.ResultsAt this moment, 21 cervical cancer patients, including ours (4 stage IA2, 16 IB1, and 1 IB2) who underwent radical trachelectomy during pregnancy have been reported. Of these, 10 were performed by vaginal route and 11 were abdominal radical trachelectomies.ConclusionsRadical trachelectomy could be offered as an option for pregnant patients with early invasive cervical cancer. It may help women avoid the triple losses of a desired pregnancy, fertility, and motherhood.

scholarly journals Oncological and Obstetric Results After Radical Trachelectomy as the Fertility-Sparing Therapy on Early-Stage (FIGO 2018 Stage IA2-IB3) Cervical Cancer Patients

2021 ◽  
Author(s):  
Tao Chen ◽  
Jia Li ◽  
Yan Zhu ◽  
AnWei Lu ◽  
Li Zhou ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Tumor Size ◽  
Early Stage ◽  
Premature Delivery ◽  
Care Hospital ◽  
Radical Trachelectomy ◽  
Trimester Abortion ◽  
Fertility Sparing ◽  
Early Stage Cervical Cancer

Abstract Purpose To explore the oncological and obstetric results after radical trachelectomy in early-stage cervical cancer. Methods Retrospective analysis of the oncological and obstetric results to 23 patients with early cervical cancer (stage IA2-IB3; International Federation of Gynecology and Obstetrics 2018) accepting radical trachelectomy in The Maternal and Child Health Care Hospital of Guiyang from Oct 2004 to Sep 2018. Results Among those patients with tumor size＞4cm (up to 5cm) three patients who wished to preserve fertility accepted radical trachelectomy after neoadjuvant chemotherapy. 23 patients had cervical tumors of the histological type squamous cell carcinoma (SCC). All of the patients retained reproductive function. The mean time of the follow-up was 112.87±55.75months(36-199months). The median tumor size was 2.00±1.35cm (invisible by eyes-5.00cm). No occurred recurrence in any of the cases. Pregnancy outcomes are described as follows: 17 cases attempted to pregnancy, in which 8 cases (47.06%) conceived 12 times. First-trimester abortion and voluntary abandonment of pregnancy occurred in 4 cases (33.33%) respectively, one among patients who choose to abandon pregnancy being induced at 24 weeks of gestation. Second-trimester abortion occurred in3 cases (25.0%), and the reason for abortion was chorioamnionitis. Premature delivery at 32 weeks occurred once (8.33%). Conclusion Radical trachelectomy is a safe and effective treatment for young women with early-stage cervical cancer. Neoadjuvant chemotherapy and Radical trachelectomy provides the possibility of preserving pregnant ability for patients with cervical tumor＞4cm. However, it is worth further exploration.

Laparoscopic Radical Trachelectomy for Young Women with Early Stage Cervical Cancer

2008 ◽  
Vol 15 (6) ◽  
pp. 155S
Author(s):  
J.H. Kim ◽  
J.Y. Park ◽  
D.Y. Kim ◽  
Y.M. Kim ◽  
Y.T. Kim ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Young Women ◽  
Early Stage ◽  
Radical Trachelectomy ◽  
Early Stage Cervical Cancer
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