Gene Polymorphisms of Toll-Like Receptor 9 −1486T/C and 2848G/A in Cervical Cancer Risk

ObjectiveThis work aims to explore whether Toll-like receptor 9 (TLR9) −1486T/C and 2848G/A polymorphisms are associated with cervical cancer risk.MethodsA comprehensive electronic search of studies published from January 1999 to October 2014 was conducted in Medline (Ovid), Embase, PubMed, Wanfang, Weipu, and CNKI. The algorithm included “TLR,” “Toll-like receptor,” “polymorphism,” “variant,” “mutation,” and “cervical cancer.” Seven articles, including 9 studies, were pooled using Revman 5.2 (Cochrane Collaboration, Copenhagen, Denmark). Odds ratio (OR) was used to explore the involvement of minor allele C (C vs T and CC + CT vs TT) of TLR9 (−1486T/C, rs187084) and minor allele A (A vs G and AA + AG vs GG) of TLR9 (2848G/A, rs352140) in cervical cancer risk.ResultsToll-like receptor 9 (−1486T/C, rs187084) polymorphisms were associated with an elevated risk of cervical cancer (C vs T: OR, 1.15; 95% confidence interval [CI], 1.03–1.29; CC + CT vs TT: OR, 1.30; 95% CI, 1.11–1.53). We found no significant association between TLR9 (2848G/A, rs352140) polymorphisms and cervical cancer risk (A vs G: OR, 1.15; 95% CI, 0.87–1.54; AA + AG vs GG: OR, 1.27; 95% CI, 0.75–2.17).ConclusionsThis meta-analysis indicates that TLR9 (−1486T/C, rs187084)—but not TLR9 (2848G/A, rs352140)—may be a risk factor for cervical cancer.

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The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility

Mediators of Inflammation ◽

10.1155/2018/9127146 ◽

2018 ◽

Vol 2018 ◽

pp. 1-11 ◽

Cited By ~ 1

Author(s):

Sijuan Tian ◽

Liping Zhang ◽

Ting Yang ◽

Xing Wei ◽

Li Zhang ◽

...

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Cochrane Library ◽

Cancer Case ◽

Type Model ◽

Toll Like Receptor ◽

Case Control Studies ◽

Cervical Cancer Risk

This meta-analysis systematically reviews the association between Toll-like receptor 9 polymorphisms and the risk of cervical cancer. Case-control studies focused on the association were collected from the PubMed, Web of Science, Cochrane Library, Embase, MEDLINE, CNKI, VIP, and Wanfang databases from inception to July 2017. We screened the studies and assessed the methodological quality of the included studies and extracted data. A meta-analysis was performed using RevMan 5.3 and Stata 12.0 software. Pooled odds ratios and 95% confidence intervals were employed to evaluate the strength of the associations between Toll-like receptor 9 polymorphisms and cervical cancer risk. A total of 9 studies comprising 3331 cervical cancer patients and 4109 healthy controls met the inclusion criteria. Of these, 8 studies contained information about G2848A (rs352140) and 4 studies contained information about −1486T/C (rs187084). Our results revealed that the associations between rs187084 and cervical cancer risk in the dominant model (p=0.002) and heterozygous model (p=0.002) were significant, with 1.30- and 1.32-fold increases in susceptibility, respectively, compared to that in the wild-type model. However, rs352140 was not related to cervical cancer regardless of whether the subgroup analysis was conducted (p>0.05). In conclusion, there is a significant correlation between rs187084 and cervical cancer risk with the minor C allele increasing the risk of occurrence of cervical cancer. However, rs352140 is not associated with the occurrence of cervical cancer.

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X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Cervical Cancer Risk: A HuGE Systematic Review and Meta-Analysis

PLoS ONE ◽

10.1371/journal.pone.0044441 ◽

2012 ◽

Vol 7 (9) ◽

pp. e44441 ◽

Cited By ~ 24

Author(s):

Ya Li ◽

Fei Liu ◽

Shi-Qiao Tan ◽

Yan Wang ◽

Shang-Wei Li

Keyword(s):

Systematic Review ◽

Cervical Cancer ◽

Cancer Risk ◽

Genetic Polymorphisms ◽

Meta Analysis ◽

X Ray ◽

Cervical Cancer Risk ◽

Group 1

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Association Between the XRCC3 Thr241Met Polymorphism and Cervical Cancer Risk: a Meta-analysis

Asian Pacific Journal of Cancer Prevention ◽

10.7314/apjcp.2013.14.11.6703 ◽

2013 ◽

Vol 14 (11) ◽

pp. 6703-6707 ◽

Cited By ~ 5

Author(s):

Ling-Yan Qin ◽

Xu Chen ◽

Ping Li ◽

Zheng Yang ◽

Wu-Ning Mo

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Meta Analysis ◽

Cervical Cancer Risk ◽

Xrcc3 Thr241met

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Association between HLA-DP Gene Polymorphisms and Cervical Cancer Risk: A Meta-Analysis

BioMed Research International ◽

10.1155/2018/7301595 ◽

2018 ◽

Vol 2018 ◽

pp. 1-13 ◽

Cited By ~ 4

Author(s):

Lin Cheng ◽

Yan Guo ◽

Shipeng Zhan ◽

Peiyuan Xia

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Human Leukocyte ◽

Cervical Cancer Risk ◽

Leukocyte Antigens ◽

Knowledge Infrastructure ◽

Increased Risk ◽

The Relationship

Objective. We aimed to derive a more precise estimation of the associations between human leukocyte antigens DP (HLA-DP) gene polymorphisms and cervical cancer risk by meta-analysis. Methods. PubMed, EMBASE, ScienceDirect, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases were systematically searched to identify studies investigating the relationship between HLA-DP gene polymorphisms and cervical cancer. The associations between them were evaluated by pooled OR and 95% CI. Results. A total of 11 studies including 5008 cases and 9322 controls with 11 HLA-DP alleles were included in the current meta-analysis. Results. The results showed that HLA-DPB1⁎03:01 was significantly associated with an increased risk of cervical cancer (OR=1.252, 95%CI: 1.116-1.403, Pz=0.001), while HLA-DPB1⁎04:02 and HLA-DP rs3117027 G allele were significantly associated with a decreased risk of cervical cancer (OR=0.744, 95%CI: 0.652-0.848, Pz=0.001; OR=0.790, 95%CI: 0.745-0.837, Pz=0.001), and HLA-DP rs9277535 G allele was significantly associated with a decreased risk of cervical cancer in Asia (OR=0.802, 95%CI: 0.753-0.855, Pz=0.001). Subgroup analyses based on race system showed that HLA-DPB1⁎13:01 was significantly associated with an increased risk of cervical cancer in Asia (OR=1.834, 95%CI: 1.107-3.039, Pz=0.019). No significant association was established for the HLA-DP following alleles: DPB1⁎02:01, DPB1⁎02:02, DPB1⁎04:01, DPB1⁎05:01, rs4282438, and rs3077. Conclusion. HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer.

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Association Between the IL-6 rs1800795 Polymorphism and the Risk of Cervical Cancer: A Meta-Analysis of 1210 Cases and 1525 Controls

Technology in Cancer Research & Treatment ◽

10.1177/1533034616672806 ◽

2016 ◽

Vol 16 (5) ◽

pp. 662-667 ◽

Cited By ~ 7

Author(s):

Haiping Liu ◽

Dan Lyu ◽

Yan Zhang ◽

Lianbing Sheng ◽

Ning Tang

Keyword(s):

Cervical Cancer ◽

Cancer Risk ◽

Interleukin 6 ◽

Fixed Effects ◽

Meta Analysis ◽

Developed Countries ◽

Nucleotide Polymorphisms ◽

Fixed Effects Model ◽

Cervical Cancer Risk ◽

Knowledge Infrastructure

Cervical cancer is the second most common cancer and the third leading cause of cancer-related death among females in less developed countries. Studies have shown that the single-nucleotide polymorphisms of interleukin 6 might be associated with cervical cancer risk. A total of 710 articles from EMBASE, EBSCO, Web of science, PubMed, Springer link, and Chinese National Knowledge Infrastructure databases were reviewed in our study. A meta-analysis on the associations between interleukin 6 rs1800795 polymorphism and cervical cancer risk was carried out by comparison using 5 genetic models. In this systematic review, 5 studies were analyzed. The pooled population included 2735 participants (1210 cases and 1525 controls). The overall odds ratio (G vs C alleles) using fixed-effects model was 0.85 (95% confidence interval 0.75-0.97), P = .02. Our results show that the C genotype of interleukin 6 rs1800795 is associated with higher cervical cancer risk. Our results indicate that interleukin 6 rs1800795 polymorphism might be associated with susceptibility to cervical cancer.

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