URINE BIOMARKER ASSESSMENT OF INFANT ADHERENCE TO ISONIAZID PROPHYLAXIS

Dr. Yerushalmy points out the excess mortality in the isoniazid pupulation in two trials: contacts of new cases and patients in mental hospitals. He failed to mention that the Public Health Service has conducted five other isoniazid prophylaxis trials (Table I). In the six trials listed, excluding the one in institutions, the isoniazid groups had more deaths in three trials, the placebo group had more deaths in two trials, and in one trial the number of deaths in each group was equal.

Download Full-text

Attentional function in secondary school students receiving isoniazid prophylaxis for tuberculosis infection

Epidemiology and Infection ◽

10.1017/s0950268899003362 ◽

2000 ◽

Vol 124 (1) ◽

pp. 97-101 ◽

Cited By ~ 3

Author(s):

D. ANDERSON ◽

V. ANDERSON ◽

L. PENTLAND ◽

S. SAWYER ◽

M. STARR ◽

...

Keyword(s):

Secondary School ◽

Processing Speed ◽

Secondary School Students ◽

School Students ◽

Attentional Function ◽

Speed Of Information Processing ◽

Serial Addition ◽

Cognitive Side Effects ◽

Poor Concentration ◽

Isoniazid Prophylaxis

Reports have suggested that isoniazid treatment may be associated with poor concentration and subtle reduction in memory. This study examines attentional function and processing speed in a group of 25 adolescents who received isoniazid prophylaxis for at least 6 months. As adolescents often face major educational assessment milestones, such cognitive side effects may have important implications. Participants were assessed before treatment, 1 month into treatment and at least 1 week after treatment cessation. Measures included the Paced Auditory Serial Addition Test and subtests of the appropriate Wechsler scale sensitive to attention and speed of information processing. Isoniazid does not appear to cause significant adverse effects on attentional function in adolescents.

Download Full-text

Isoniazid prophylaxis underutilised in older TB contacts

Inpharma Weekly ◽

10.2165/00128413-199510070-00028 ◽

1995 ◽

Vol &NA; (1007) ◽

pp. 12

Author(s):

&NA;

Keyword(s):

Isoniazid Prophylaxis

Download Full-text

Association of Blood and Urine Parameter Value Change With the Amount of Consumed Water Regime and Sample Sampling in Healthy Individuals

10.21203/rs.3.rs-258592/v1 ◽

2021 ◽

Author(s):

Snezana M Jovicic

Keyword(s):

Water Intake ◽

Freezing Point ◽

Freezing Point Depression ◽

Sodium Potassium ◽

Significant Difference ◽

Urine Biomarker ◽

Concentration Changes ◽

The Difference ◽

And Gender

Abstract Background: Understanding the effect of pre-analytical factors is important for data quality of bio-specimens and health status. The study examines the effect of 9-days fluid intake and 2-time sampling on concentration changes of 7-Urine and 17-Blood variables. Material and Method: SPSS software v23.0 applies to data processing. The group of 23 healthy subjects divide based on water intake and gender. Results: A statistically significant difference(p<0.01) between 1st/2nd sampling is confirmed for Freezing point depression, Sodium, Potassium, Creatinine Urea and Urate in Urine and Urea, Urate, Glucose, Hematocrit, Thrombocyte in Blood. The difference between water intake after 1st sampling is confirmed (p<0.01) for Freezing point depression, Sodium, Urate and(p<0.05) for Potassium(p<0.05), Chloride(p<0.05), Creatinine(p<0.05), Urate, Urea in Urine and Potassium(p<0.01) and Chloride(p<0.05) in Blood. Difference between gender exists for Urea(p<0.05) in Urine after 2nd sampling and Urate(P<0.01), Glucose(p<0.01/0.05), Ht(p<0.01/0.05) after 1st and 2nd sampling and MCHC(p<0.01) after 2nd sampling in Blood samples.Conclusion: Water intake increases blood and urine biomarker range after sampling.

Download Full-text