scholarly journals Systematic review and meta-analysis of genetic risk factors for neuropathic pain

Pain ◽  
2018 ◽  
Vol 159 (5) ◽  
pp. 825-848 ◽  
Author(s):  
Abirami Veluchamy ◽  
Harry L. Hébert ◽  
Weihua Meng ◽  
Colin N.A. Palmer ◽  
Blair H. Smith
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Neuropathic Pain ◽  
Genetic Risk ◽  
Meta Analysis ◽  
Genetic Risk Factors

Genetic risk factors for pathogenic IgG4 autoantibodies: a systematic review and meta-analysis of HLA class II associations in patients with IgG4 autoimmune diseases

2021 ◽  
Author(s):  
Anja Panhuber ◽  
Giovanni Lamorte ◽  
Veronica Bruno ◽  
Hakan Cetin ◽  
Wolfgang Bauer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Autoimmune Diseases ◽  
Genetic Risk ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
Pemphigus Vulgaris ◽  
Genetic Risk Factors ◽  
Case Control Studies ◽  
Leukocyte Antigen

Abstract Autoimmune diseases caused by pathogenic IgG4 subclass autoantibodies (IgG4-AID) include diseases like MuSK myasthenia gravis, pemphigus vulgaris or thrombotic thrombocytopenic purpura. Their etiology is still unknown. Polymorphisms in the human leukocyte antigen (HLA) gene locus, particularly in HLA-DRB1, are known genetic susceptibility factors for autoimmune diseases. We hypothesized a similar role for HLA polymorphisms in IgG4-AID and conducted a systematic review and meta-analysis with case-control studies on IgG4-AID based on MOOSE and HuGENet guidelines. Genotype (G) and allele (A) frequencies of HLA-DQB1*05 (G: OR 3.8; 95% CI 2.44-5.9; p < 0.00001; A: OR 2.54; 95% CI 1.82-3.55; p < 0.00001) and HLA-DRB1*14 (G: OR 4.31; 95% CI 2.82-6.59; p < 0.00001; A: OR 4.78; 95% CI 3.52-6.49; p < 0.00001) and the HLA-DRB1*14-DQB1*05 haplotype (OR 6.3; 95% CI 3.28-12.09; p < 0.00001 / OR 4.98; 95% CI 3.8-6.53; p < 0.00001) were increased while HLA-DRB1*13 (G: OR 0.48; 95% CI 0.34-0.68; p < 0.0001; A: OR 0.46; 95% CI 0.34-0.62; p < 0.00001) was decreased in IgG4-AID patients. In conclusion, the HLA-DQB1*05 , HLA-DRB1*14 alleles and the HLA-DQB1*05-DRB1*14 haplotype could be genetic risk factors that predispose for the production of pathogenic IgG4 autoantibodies and the HLA-DRB1*13 allele may protect from IgG4 autoimmunity.

Lifestyle and sociodemographic risk factors for gastroschisis: a systematic review and meta-analysis

2020 ◽  
Vol 105 (8) ◽  
pp. 756-764 ◽  
Author(s):  
Silvia Baldacci ◽  
Michele Santoro ◽  
Alessio Coi ◽  
Lorena Mezzasalma ◽  
Fabrizio Bianchi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Genetic Risk ◽  
Illicit Drugs ◽  
Meta Analysis ◽  
Genetic Risk Factors ◽  
Epidemiological Studies ◽  
Black Mothers ◽  
Increased Risk ◽  
Sociodemographic Risk ◽  
Meta Analyses

BackgroundGastroschisis is strongly associated with young maternal age. This association suggests the need for further investigations on non-genetic risk factors. Identifying these risk factors is a public health priority in order to develop prevention strategies aimed at reducing the prevalence and health consequences in offspring.ObjectiveTo systematically assess and quantitatively synthesise the available epidemiological studies to evaluate the association between non-genetic risk factors and gastroschisis.MethodsLiterature from PubMed, EMBASE and Scopus was searched for the period 1990–2018. Epidemiological studies reporting risk estimates between lifestyle and sociodemographic risk factors and gastroschisis were included. Two pairs of reviewers independently extracted information on study characteristics following Preferred Reporting Items for Systematic Reviews and Meta-Analyses and MOOSE (Meta-analysis Of Oservational Studies in Epidemiology) guidelines. Relative risk (RR) estimates were calculated across the studies and meta-analysis was performed using random-effects model.ResultsWe identified 58 studies. Meta-analyses were conducted on 29 studies. Maternal smoking (RR 1.56, 95% CI 1.40 to 1.74), illicit drug use (RR 2.14, 95% CI 1.48 to 3.07) and alcohol consumption (RR 1.40, 95% CI 1.13 to 1.70) were associated with an increased risk of gastroschisis. A decreased risk among black mothers compared with non-Hispanic white mothers (RR 0.49, 95% CI 0.38 to 0.63) was found. For Hispanic mothers no association was observed.ConclusionsExposure to smoking, illicit drugs and alcohol during pregnancy is associated with an increased risk of gastroschisis. A significantly decreased risk for black mothers was observed. Further epidemiological studies to assess the potential role of other environmental factors are strongly recommended.PROSPERO registration numberCRD42018104284.

The Genetics of Endometriosis

2020 ◽  
Vol 23 (2) ◽  
pp. 103-104
Author(s):  
Grant W. Montgomery
Keyword(s):  
Risk Factors ◽  
New York ◽  
Human Disease ◽  
Genetic Risk ◽  
Meta Analysis ◽  
Genetic Risk Factors ◽  
Scientific Meeting ◽  
Research Centre ◽  
Cooperative Research ◽  
The World

AbstractMapping genetic risk factors for endometriosis continues from early studies on women’s health initiated by Nick Martin and Susan Treloar. Their initial recruitment of endometriosis cases and family members received a major boost and became a flagship project within the Cooperative Research Centre (CRC) for the Discovery of Common Human Disease. We extended the study through a formal collaboration with Professor Stephen Kennedy and his group in Oxford. Our first joint scientific meeting was held in Brisbane and was sadly memorable as the day the planes were flown into the Twin Towers in New York. Our initial collaboration expanded into the International Endometriosis Genetics Consortium (IEGC). The IEGC now has 15 groups around the world, and the most recent meta-analysis will be published this year.

Genetic risk factors for glucocorticoid-induced osteonecrosis: A meta-analysis

Steroids ◽  
2013 ◽  
Vol 78 (4) ◽  
pp. 401-408 ◽  
Author(s):  
Li-Li Gong ◽  
Lian-Hua Fang ◽  
He-Yao Wang ◽  
Jian-Hao Peng ◽  
Kun Si ◽  
...  
Keyword(s):  
Risk Factors ◽  
Genetic Risk ◽  
Meta Analysis ◽  
Genetic Risk Factors

Genetic Risk Factors for Idiopathic Urolithiasis: A Systematic Review of the Literature and Causal Network Analysis

2017 ◽  
Vol 3 (1) ◽  
pp. 72-81 ◽  
Author(s):  
Kazumi Taguchi ◽  
Takahiro Yasui ◽  
Dawn Schmautz Milliner ◽  
Bernd Hoppe ◽  
Thomas Chi
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Network Analysis ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Causal Network ◽  
Review Of The Literature

scholarly journals Genetic risk factors for cancer-related cognitive impairment: a systematic review

2019 ◽  
Vol 58 (5) ◽  
pp. 537-547 ◽  
Author(s):  
Cecilie D. R. Buskbjerg ◽  
Ali Amidi ◽  
Ditte Demontis ◽  
Eva R. Nissen ◽  
Robert Zachariae
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Cognitive Impairment ◽  
Genetic Risk ◽  
Genetic Risk Factors

Genetic risk factors for modulation of age at onset in Machado-Joseph disease/spinocerebellar ataxia type 3: a systematic review and meta-analysis

2018 ◽  
Vol 90 (2) ◽  
pp. 203-210 ◽  
Author(s):  
Eduardo Preusser de Mattos ◽  
Maiara Kolbe Musskopf ◽  
Vanessa Bielefeldt Leotti ◽  
Maria Luiza Saraiva-Pereira ◽  
Laura Bannach Jardim
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Spinocerebellar Ataxia ◽  
Genetic Risk ◽  
Meta Analysis ◽  
Age At Onset ◽  
Spinocerebellar Ataxia Type ◽  
Spinocerebellar Ataxia Type 3 ◽  
Specific Factors ◽  
Type 3

ObjectivesTo perform a systematic review and meta-analysis of genetic risk factors for age at onset (AO) in spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD).MethodsTwo authors independently reviewed reports on the mathematical relationship between CAG length at the expanded ATXN3 allele (CAGexp), and other genetic variants if available, and AO. Publications from January 1994 to September 2017 in English, Portuguese or Spanish and indexed in MEDLINE (PubMed), LILACS or EMBASE were considered. Inclusion criteria were reports with >20 SCA3/MJD carriers with molecular diagnosis performed by capillary electrophoresis. Non-overlapping cohorts were determined on contact with corresponding authors. A detailed analysis protocol was registered at the PROSPERO database prior to data extraction (CRD42017073071).ResultsEleven studies were eligible for meta-analysis, comprising 10 individual-participant (n=2099 subjects) and two aggregated data cohorts. On average, CAGexp explained 55.2% (95% CI 50.8 to 59.0; p<0.001) of AO variability. Population-specific factors accounted for 8.3% of AO variance. Cohorts clustered into distinct geographic groups, evidencing significantly earlier AO in non-Portuguese Europeans than in Portuguese/South Brazilians with similar CAGexp lengths. Presence of intermediate ATXN2 alleles (27–33 CAG repeats) significantly correlated with earlier AO. Familial factors accounted for ~10% of AO variability. CAGexp, origin, family effects and CAG length at ATXN2 together explained 73.5% of AO variance.ConclusionsCurrent evidence supports genetic modulation of AO in SCA3/MJD by CAGexp, ATXN2 and family-specific and population-specific factors. Future studies should take these into account in the search for new genetic modifiers of AO, which could be of therapeutic relevance.

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