scholarly journals The Relationship Between the Acute Cerebral Metabolic Response to Citalopram and Chronic Citalopram Treatment Outcome

2011 ◽  
Vol 19 (1) ◽  
pp. 53-63 ◽  
Author(s):  
Gwenn S. Smith ◽  
Clifford I. Workman ◽  
Elisse Kramer ◽  
Carol R. Hermann ◽  
Rachel Ginsberg ◽  
...  
2011 ◽  
Author(s):  
Kathryn Palmer ◽  
Katherine L. Thompson ◽  
Debora A. D'Iuso ◽  
Deborah Schwartzman ◽  
Keith S. Dobson ◽  
...  

2021 ◽  
pp. 1-7
Author(s):  
Alastair J. Flint ◽  
Kathleen S. Bingham ◽  
Nicholas H. Neufeld ◽  
George S. Alexopoulos ◽  
Benoit H. Mulsant ◽  
...  

Abstract Background Little is known about the relationship between psychomotor disturbance (PMD) and treatment outcome of psychotic depression. This study examined the association between PMD and subsequent remission and relapse of treated psychotic depression. Methods Two hundred and sixty-nine men and women aged 18–85 years with an episode of psychotic depression were treated with open-label sertraline plus olanzapine for up to 12 weeks. Participants who remained in remission or near-remission following an 8-week stabilization phase were eligible to participate in a 36-week randomized controlled trial (RCT) that compared the efficacy and tolerability of sertraline plus olanzapine (n = 64) with sertraline plus placebo (n = 62). PMD was measured with the psychiatrist-rated sign-based CORE at acute phase baseline and at RCT baseline. Spearman's correlations and logistic regression analyses were used to analyze the association between CORE total score at acute phase baseline and remission/near-remission and CORE total score at RCT baseline and relapse. Results Higher CORE total score at acute phase baseline was associated with lower frequency of remission/near-remission. Higher CORE total score at RCT baseline was associated with higher frequency of relapse, in the RCT sample as a whole, as well as in each of the two randomized groups. Conclusions PMD is associated with poorer outcome of psychotic depression treated with sertraline plus olanzapine. Future research needs to examine the neurobiology of PMD in psychotic depression in relation to treatment outcome.


2003 ◽  
Vol 29 (2) ◽  
pp. 263-279 ◽  
Author(s):  
Stephen Ross ◽  
Helen Dermatis ◽  
Petros Levounis ◽  
Marc Galanter

1986 ◽  
Vol 250 (3) ◽  
pp. R377-R382 ◽  
Author(s):  
M. E. Heath ◽  
H. T. Hammel

Body temperatures and rates of O2 consumption and CO2 production were measured in four Chinese pangolins (Manis pentadactyla) during short-term exposures (2-4 h) to ambient temperatures (Ta) of 10-34 degrees C. At Ta less than 27 degrees C the pangolins curled into a sphere. At Ta greater than 28 degrees C the animals laid on their backs with their soft abdominal skin exposed. Rectal temperatures between 33.4 and 35.5 degrees C were recorded from animals exposed to Ta of 10-32 degrees C. At Ta greater than or equal to 32 degrees C the animals appeared to be markedly heat stressed, rate of breathing was elevated, and core temperature rose somewhat. Resting metabolic rates averaged 3.06 ml O2 X kg-1 X min-1. This is significantly lower than would be predicted from the relationship between body mass and metabolic rate established by Kleiber (The Fire of Life: an Introduction to Animal Energetics. New York: Wiley, 1975) for other eutherian mammals. The magnitude of the metabolic response to Ta below the lower critical temperature was inversely correlated to the mass of the pangolin, the slope being greatest for the smallest animals. Respiratory quotients of 0.85-1.0 were observed.


2013 ◽  
Vol 27 (3) ◽  
pp. 696-704 ◽  
Author(s):  
Brian L. Odlaug ◽  
Randy Stinchfield ◽  
Ezra Golberstein ◽  
Jon E. Grant

2021 ◽  
Author(s):  
Racine E. Rangel ◽  
Cascade J.B. Sorte

Abstract As climate change continues, anticipating species’ responses to rising temperatures, requires an understanding of the relationship between metabolic rate and thermal sensitivity, which itself may vary over space and time. We measured metabolic rates of three representative marine invertebrate species (hermit crabs Pagurus hirsutiusculus, periwinkle snails Littorina sitkana, and mussels Mytilus trossulus) and evaluated the relationship between thermal sensitivity (Q10) and thermal history. We tested the hypothesis that thermal history drives thermal sensitivity and quantified how this relationship differs over time (short-term to seasonal time scales) and between species. Organisms were collected from tide pools in Sitka, Alaska where we also recorded temperatures to characterize thermal history prior to metabolic rate assays. Using respirometry, we estimated mass-specific oxygen consumption (MO2) at ambient and increased temperatures for one individual per species per tide pool across three seasons. We evaluated relationships between thermal sensitivity and pool temperatures for time periods ranging from 1 day to 3 months prior to collection. For all species, thermal sensitivity was related to thermal history for the shorter time periods (1 day to 1 week). However, the direction of the relationships and most important thermal parameters (i.e., maximum, mean, or range) differed between species and seasons. We found that on average, P. hirsutiusculus and L. sitkana were more thermally sensitive than M. trossulus. These findings show that variability in thermal history over small spatial scales influences individuals’ metabolic response to warming and may be indicative of these species’ ability to acclimate to future climate change.


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