Does high serum uric acid level cause aspirin resistance?

2016 ◽  
Vol 27 (4) ◽  
pp. 412-418 ◽  
Author(s):  
Bekir S. Yildiz ◽  
Emel Ozkan ◽  
Fatma Esin ◽  
Yusuf I. Alihanoglu ◽  
Hayrettin Ozkan ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Aspirin Resistance ◽  
High Serum

scholarly journals Relationship Between Uric Acid Level and Blood Pressure in T2DM Patient Attending in BIRDEM General Hospital

2018 ◽  
Vol 9 (2) ◽  
pp. 49-53
Author(s):  
S Ferdous ◽  
K Begum ◽  
MA Muttalib
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Stone Formation ◽  
Serum Uric Acid Level ◽  
High Serum ◽  
Normal Serum ◽  
Significant Difference

Hyperuricemia is associated with higher mortality in patients suffering from hypertension, coronary heart disease, cerebrovascular events, metabolic syndrome, insulin resistance, gout and renal stone formation and it is more in individuals with diabetes. The prevalence of hyperuricemia is high in T2DM. The aim of the present study was to assess the relationship between hyperuricemia and blood pressure in T2DM subjects and thus to help the clinician for early diagnosis, treatment and to prevent further complications. Total 350 study subjects were enrolled for this study; among them 203 were T2DM with normal level of serum uric acid level and 147 were T2DM with high serum uric acid level. It was observed that systolic blood pressure was significantly higher (134.5±9.6 mm of Hg) in T2DM with hyperuricemia (p<0.001) than T2DM with normal serum uric acid level (123.3±10.9 mm of Hg). On the other hand diastolic blood pressure was significantly higher (87.1±5.9 mm of Hg) in T2DM with hyperuricemia (p<0.001) than T2DM with normal serum uric acid level (79.6±8.3 mm of Hg). Age (years) showed no significant difference between T2DM with serum uric acid<7 mg/dl and T2DM with serum uric acid>7 mg/dl (p<0.05). In our study it was revealed that males were in greater risk of developing hyperuricemia. BMI was significantly (p<0.001) greater in T2DM subjects who had normal serum uric acid level (27.9±3.8) than with those who had serum uric acid>7 mg/dl (24.4±3.83). No significant differences were found in FBS, blood sugar 2 hours after breakfast, HbA1C, serum creatinine and blood urea between groups.Bangladesh J Med Biochem 2016; 9(2): 49-53

scholarly journals ESSENTIAL HYPERTENSION

2015 ◽  
Vol 22 (07) ◽  
pp. 854-858
Author(s):  
Muhammad Iqbal Shah ◽  
Ramesh Kumar Suthar ◽  
Mukhtiar Ahmed Soomro
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
High Blood Pressure ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
High Serum ◽  
Research Studies

Background: Little and sparse information is present in our population onassociation between serum uric acid and essential hypertension .Increased serum uric acid isrelated with elevated blood pressure in different research studies. The relationship betweenserum uric acid level and high blood pressure can be difficult to assess because drugs for highblood pressure usually affect uric acid level. Objectives: The objective of our study is to evaluatethe association of serum uric acid to severity and duration of essential hypertension at LiaquatUniversity Hospital (tertiary care) Hyderabad / Jamshoro Methodology: Study Design: Casecontrol and prospective study. Setting: Medical wards and Out Patient Medicine Department ofLiaquat University Hospital Hyderabad / Jamshoro. Period: One year i.e. from 20th March 2013to 19th February 2014. Methodology: A total of 75 high blood pressure subjects aged 35 yearsand above were included as cases with same number(75) of age & sex matched normal bloodpressure subjects as controls after excluding, Secondary hypertension, metabolic syndrome,Diabetes Mellitus, age <40 ;>70 years, hypothyroidism, hyperparathyroidism, Ischemic heartdisease, congestive cardiac failure,Alcohol abuse, Renal Insufficiency, glomerulonephritis,pyelonephritis, hereditary nephropathy, patients on drugs –, ethambutol,levodopa pyrazinamide,low dose asprin, Cytotoxic drugs, nicotinic acid ,thiazide diuretics.. Qualitative and quantitativedata were evaluated in SPSS version 16.0. Results: The mean serum uric acid level was 6.3± 1.4 mg/dl vs 4.5 ± 1.2 mg/dl in case (n = 75) and control patients (n = 75) respectively. Atotal of 23 (30.6%, n = 75) patients in cases and 8 (10.6%) subjects in control had high serumuric acid (Odds Ratio 2.13, p <0.05). Therefore, the frequency of increased serum uric acidlevel subjects & mean serum uric acid level were significantly greater in hypertensive cases,as compared to those of healthy normal blood pressure Controls. Serum uric acid correlatedpositively with both systolic blood pressure (r=0.132, p<0.01) and diastolic blood pressure(r=0.214; p<0.01). Conclusion: High serum uric acid is frequent in our populace with essentialhypertension and there is relationship between serum uric acid level and blood pressure.Further large scale research studies on the pathophysiologic significance of high serum uricacid in these high blood pressure patients are in further need.

scholarly journals Association Between Serum Uric Acid Level and Psoriasis: A Case Control Study

2021 ◽  
Vol 19 (1) ◽  
pp. 50-54
Author(s):  
Aruna Sayami ◽  
Aatmaram Gupta ◽  
Narayan Gautam
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Case Control Study ◽  
Serum Uric Acid Level ◽  
Acid Value ◽  
High Serum ◽  
Control Group ◽  
Control Study

Introduction: Psoriasis is a common, chronic, inflammatory and proliferative condition of the skin, associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with metabolic syndrome. Hyperuricemia is associated with psoriasis and psoriatic arthritis. Objectives: To find out the association of serum uric acid with psoriasis. Materials and Method:  It was a case-control study including 104 patients, among them 52 were psoriatic patients (case) and 52 had disease other than psoriasis (control) after matching for age and sex. The study was conducted at Department of Dermatology, Universal College of Medical Science, from January- December 2017. Clinical examination and proforma documentation including patient details, laboratory values of serum uric acid level, Psoriasis Area and Severity Index score were studied. Results:  Mean SUA in psoriasis patients was 4.70±1.37 mg/dl in female, 5.57±1.18 mg/dl in male whereas 4.85±0.74 mg/dl in female and 4.34 ± 0.98 mg/dl in male respectively in control group (p=0.002). Six (18.88%) male and three (15.78%) female patients with psoriasis had higher serum uric acid value whereas only four (3.84%) patient  had  higherserum uric acid  value in control group (p=0.012). There was association between serum uric acid and psoriasis. Conclusion: Our study concludes that serum uric acid level is increased in psoriasis patients when compared with controls. Monitoring of psoriatic patients for high serum uric acid levels during treatment and follow up should be done to prevent the its deleterious effect on psoriasis.

Maternal Serum Uric Acid as an Index of Perinatal Outcomes in Severe Preeclampsia

2018 ◽  
pp. 80-84
Author(s):  
Rozhan Yassin Khalil ◽  
Awat Saber Muhammed
Keyword(s):  
Uric Acid ◽  
Standard Deviation ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Perinatal Outcomes ◽  
High Serum ◽  
Maternal Serum ◽  
Severe Preeclampsia

Preeclampsia is a multisystem disorder characterized by gestational hypertension after the 20th week of gestation with proteinuria, is common and dangerous adverse event of pregnancy. Several studies reported relationship between uric acid concentrations and severity of disease in pregnant women. The objective of this study was to explore the relation between serum uric acid level and perinatal outcomes. A case–control study conducted in Sulaimani Maternity Teaching Hospital from January 2014 to July 2014. Included 100 pregnant women in third trimester with signs and symptoms of labour, who had no comorbid diseases. Grouped to 30 control without hypertension, 30 with pregnancy induced hypertension (PIH) and 40 with severe preeclampsia based on clinical and laboratory evaluation. SPSS v21 was used for obtain mean, standard deviation, frequency and percentage. One way ANOVA test used to obtain P value with consider <0.05 significant value. Results show serum uric acid mean and standard deviation (±SD) for control, PIH and severe preeclampsia groups were (5.83 ± 9.544), (4.35 ± 1.372) and (7.59 ± 0.508) respectively. The positive and significant (˂ 0.001) correlation coefficient was found between high serum uric acid level and oligohydramnios, low birth weight and low Apgar score. The highest level of serum uric acid was recorded in preeclampsia group and the lowest level was in PIH group. Significant and adverse perinatal outcomes relation were noted in the patients with high serum uric acid (>7 mg/dl); decreased amniotic fluid index (AFI), caused low birth weight and low Apgar score. In   conclusion that severity of illness in pregnant preeclampsia cases can be estimated by serum uric acid level and high serum uric acid indicate high risk cases. Maternal serum uric acid is a useful index for estimate fetal health status and predict neonate outcomes.

A STUDY OF SERUM URIC ACID LEVELS IN PREECLAMPSIA

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Sushma Goad ◽  
Anita Verma ◽  
Subhash Chandra
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Age Group ◽  
Hypertensive Disorders Of Pregnancy ◽  
Level Elevation ◽  
The Mean

Background: To Study Serum Uric Acid level elevation in Hypertensive Disorders of Pregnancy. Methods: 50 Patients diagnosed as having Pre-eclampsia with age between 18-37 years and 50 controls with similar age group. Results: The mean serum uric acid level in control group was 3.41 ± 0.62 and in patient 7.01 ± 0.58 which was statistically significant (p =0.001). Conclusion: Serum uric acid levels were significantly higher in preeclampsia could be a useful indicator of fetal complication in preeclampsia patients. Keywords: serum uric acid, preeclampsia, laboratory.

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