Glucose metabolism of visceral adipose tissue measured by 18F-FDG PET/CT is related to the presence of colonic adenoma

Obesity contributes to increased cancer incidence and aggressiveness in patients with endometrial cancer. Inflamed metabolic activity of visceral adipose tissue (VAT) is regarded as a key underlying mechanism of adverse consequences of obesity. The aim of this study was to investigate the association between inflammatory metabolic activity of VAT evaluated by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and metastatic status of lymph nodes (LN) in patients with endometrial cancer. In total, 161 women with newly diagnosed endometrial cancer, who received preoperative 18F-FDG PET/CT, were enrolled. VAT inflammatory metabolic activity was defined as V/S ratio and measured from the maximum standardized uptake value (SUVmax) of VAT normalized to the SUVmax of subcutaneous adipose tissue (SAT). The positive LN metastasis group exhibited a significantly higher V/S ratio than the negative LN metastasis group. Systemic inflammatory surrogate markers including high sensitivity C-reactive protein, spleen SUVmax, and bone marrow SUVmax were also higher in the LN metastasis group than in the negative LN metastasis group, showing significant correlations with V/S ratio. In multivariate logistic regression analysis, V/S ratio was independently associated with LN metastasis. V/S ratio is independently associated with the LN metastasis status in patients with endometrial cancer. This finding could be useful as a potential surrogate marker of obesity-induced VAT inflammation associated with tumor aggressiveness.

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Prognosis predicting value of semiquantitative parameters of visceral adipose tissue and subcutaneous adipose tissue of 18F-FDG PET/CT in newly diagnosed secondary hemophagocytic lymphohistiocytosis

Annals of Nuclear Medicine ◽

10.1007/s12149-021-01577-9 ◽

2021 ◽

Vol 35 (3) ◽

pp. 386-396

Author(s):

Jun Liu ◽

Xu Yang ◽

Jigang Yang

Keyword(s):

Adipose Tissue ◽

Visceral Adipose Tissue ◽

Subcutaneous Adipose Tissue ◽

Newly Diagnosed ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Visceral Adipose ◽

Subcutaneous Adipose ◽

Secondary Hemophagocytic Lymphohistiocytosis

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Coronary Plaque Instability is Linked with Inflammatory Activity of Multiple Organs Including Carotid Plaques and Visceral Adipose Tissue: A Pilot F-18 FDG PET/CT Study

Metabolism ◽

10.1016/j.metabol.2019.12.048 ◽

2020 ◽

Vol 104 ◽

pp. 154102

Author(s):

Kisoo Pahk ◽

Hyun Woo Kwon ◽

Jae Seon Eo ◽

Hong Seog Seo ◽

Won-Ki Kim ◽

...

Keyword(s):

Adipose Tissue ◽

Visceral Adipose Tissue ◽

Fdg Pet ◽

Coronary Plaque ◽

Inflammatory Activity ◽

Plaque Instability ◽

Multiple Organs ◽

Pet Ct ◽

Fdg Pet Ct ◽

Visceral Adipose

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Coronary Plaque Instability Is Linked With Inflammatory Activity Of Multiple Organs Including Carotid Plaques And Visceral Adipose Tissue: A Pilot F-18 Fdg Pet/Ct Study

Atherosclerosis ◽

10.1016/j.atherosclerosis.2019.06.743 ◽

2019 ◽

Vol 287 ◽

pp. e242

Author(s):

K. Pahk ◽

H.Y. Cho ◽

H.R. Kwon ◽

S. Choi ◽

H.W. Kwon ◽

...

Keyword(s):

Adipose Tissue ◽

Visceral Adipose Tissue ◽

Fdg Pet ◽

Coronary Plaque ◽

Inflammatory Activity ◽

Plaque Instability ◽

Multiple Organs ◽

Pet Ct ◽

Fdg Pet Ct ◽

Visceral Adipose

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Coronary plaque instability is associated with inflammatory activity of visceral adipose tissue and carotid artery: a prospective pilot F-18 FDG PET/CT study

European Heart Journal ◽

10.1093/ehjci/ehaa946.1554 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

K Pahk ◽

H.W Kwon ◽

J.S Eo ◽

H.S Seo ◽

S Kim

Keyword(s):

Adipose Tissue ◽

Carotid Artery ◽

Systemic Inflammation ◽

Fdg Pet ◽

Coronary Plaque ◽

Inflammatory Activity ◽

Plaque Instability ◽

Pet Ct ◽

Fdg Pet Ct ◽

Visceral Adipose

Abstract Background Dysfunctional Visceral adipose tissue (VAT) secretes pro-inflammatory cytokines and promotes inflammatory cell infiltration into VAT thereby boosting insulin resistance and systemic inflammation which eventually lead to increased risk of cardiovascular disease (CVD). F-18 FDG PET/CT is well known to reflect the inflammatory activity of classically activated (M1) macrophage. Purpose We hypothesized that F-18 FDG PET/CT could reflect the inflammatory activity of dysfunctional VAT and carotid artery which were associated with coronary plaque instability. Methods A total of 90 participants were enrolled in this prospective study. F-18 FDG PET/CT was performed in 32 participants with acute myocardial infarction (AMI) within a week of disease onset, 33 participants with stable coronary artery disease (CAD), and 25 control subjects. Maximum standardized uptake value (SUVmax) was calculated in VAT, subcutaneous adipose tissue (SAT), spleen, and bone marrow (BM). Target-to-background ratio (TBR) was calculated in right carotid artery and right jugular vein. Results The SUVmax of VAT and the TBR of right carotid artery were highest in patients with AMI, intermediate in patient with stable CAD, and lowest in control subjects. Systemic inflammation surrogate markers such as high-sensitivity C-reactive protein, spleen SUVmax were also showed similar pattern like the SUVmax of VAT and the TBR of right carotid artery. Furthermore, multiple linear regression analysis showed that the SUVmax of VAT and spleen SUVmax were independently associated with the TBR of right carotid artery. Conclusions F-18 FDG PET/CT could reflect the synchronized systemic inflammation in VAT and carotid artery which could affect the coronary artery instability. Furthermore, our findings offer clinical insights into risk stratification, monitoring of therapy, and physiological changes in the development of CAD. Funding Acknowledgement Type of funding source: None

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The Relationship between Brown Adipose Tissue Activity and Neoplastic Status: an 18F-FDG PET/CT Study in the Tropics

Lipids in Health and Disease ◽

10.1186/1476-511x-10-238 ◽

2011 ◽

Vol 10 (1) ◽

pp. 238 ◽

Cited By ~ 18

Author(s):

Yung-Cheng Huang ◽

Tai-Been Chen ◽

Chien-Chin Hsu ◽

Shau-Hsuan Li ◽

Pei-Wen Wang ◽

...

Keyword(s):

Adipose Tissue ◽

Brown Adipose Tissue ◽

Fdg Pet ◽

Brown Adipose ◽

Pet Ct ◽

18F Fdg ◽

Brown Adipose Tissue Activity ◽

Fdg Pet Ct ◽

The Tropics ◽

The Relationship

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P2497Exercise training could reduce inflammatory activity of visceral adipose tissue in overweight women

European Heart Journal ◽

10.1093/eurheartj/ehz748.0826 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

K Pahk ◽

H W Kwon ◽

J S Eo ◽

H S Seo ◽

W Kim ◽

...

Keyword(s):

Adipose Tissue ◽

Exercise Training ◽

Training Program ◽

Fdg Pet ◽

Exercise Program ◽

Inflammatory Activity ◽

Exercise Training Program ◽

Pet Ct ◽

Fdg Pet Ct ◽

Visceral Adipose

Abstract Objectives Visceral adipose tissue (VAT) plays pivotal roles for an increased risk of cardiometabolic disease through triggering inflammatory process. This prospective study aimed to evaluate whether the exercise training could reduce inflammatory activity of VAT assessed by 18F-fluorodeoxyglucoase (FDG) positron emission tomography-computerized tomography (PET/CT). Methods Twenty-three overweight women who participated in exercise training program were included. Exercise training program was composed of aerobic exercise (45 min/session, 300 Kcal/day) and muscle strength training (20 min/session, 100 Kcal/day) 5 times per week for 3 months. They underwent F-18 FDG PET/CT before starting exercise program (baseline) and after completion of 3 months exercise program. Anthropometric data, clinical laboratory data, VAT area, and maximum standardized uptake value (SUVmax) of VAT were compared between baseline and after completion of the total exercise program. Results Baseline VAT SUVmax showed significant correlation with body weight, body mass index (BMI), waist circumference, and hip circumference. VAT SUVmax was significantly reduced by exercise training program. Exercise training program also reduced body weight, BMI, waist circumference, hip circumference, VAT area, subcutaneous adipose tissue area and blood pressure. The change of VAT SUVmax was significantly higher than the change of VAT area. Conclusions Exercise training could reduce the inflammatory activity of VAT assessed by F-18 FDG PET/CT. Thus, exercise would be a promising non-pharmacological strategy to reduce inflammatory activity of VAT. Furthermore, F-18 FDG PET/CT could be useful to evaluate the effect of therapeutic intervention targeted to inflammatory VAT activity.

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