Determining the association between hypertension and bone metabolism markers in osteoporotic patients

ABSTRACT Introduction Epilepsy is a disorder of the central nervous system, characterized by an epileptic seizure. Epileptic seizures occur due to abnormal synchronous activity in the brain. Calcium is an essential component of bone. Hypocalcemia enhances neuronal excitability, and there are many causes of which include hypocalcemia, vitamin D deficiency, and PTH resistance. Materials and methods The study was conducted in Department of Biochemistry in association with the Department of Neurology of Mahatma Gandhi Medical College and Hospital, Jaipur. Fifty patients diagnosed for epileptic seizure and 50 controls, visiting the inpatient department (IPD) and outpatient department (OPD) of Neurology fulfilling the inclusion criteria, were enrolled for the study. Result The present study showed significantly lower level of serum calcium in patients with epileptic seizure when compared to controls. Conclusion The serum calcium was measured between epileptic seizure and controls. Our present study showed significantly lower value of calcium. It is therefore suggested that there should be regular screening for calcium in patients with epileptic seizure. The serum calcium is biomarker of bone metabolism; so, the correlation can be further studied with some more bone metabolism markers in epileptic seizure patients. How to cite this article Sharma S, Fiza B, Tiwari SK, et al. Evaluation of Serum Calcium Levels in Patients with Epileptic Seizure. J Mahatma Gandhi Univ Med Sci Tech 2020;5(2):35–37.

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Сalcium-phosphorus balance and bone metabolism markers estimation in the combination therapy of patients with chronic generalized severe periodontitis

The actual problems in dentistry ◽

10.18481/2077-7566-2016-12-2-25-29 ◽

2016 ◽

Vol 12 (2) ◽

pp. 25-29

Author(s):

А. Казакова ◽

A. Kazakova ◽

М. Гуртовая ◽

M. Gurtovaya

Keyword(s):

Combination Therapy ◽

Bone Metabolism ◽

Periodontal Diseases ◽

Ionized Calcium ◽

Balance Study ◽

Bone Metabolism Markers ◽

Phosphorus Balance ◽

Low Level ◽

Periodontal Tissues ◽

Severe Periodontitis

<p class="p1"><span class="s1">The serum calcium-phosphorus balance and bone metabolism markers estimation in 72 patients with severe chronic generalized periodontitis and 20 patients of control healthy group at the age of 25 to 55 was performed. A comprehensive laboratory mineral balance study plays an important role in modern diagnostics of periodontal diseases and allows not only to determine the process of bone destruction activity, but also to control the periodontal treatment ef ciency. The rst examination revealed that 19,4% patients with severe periodontitis had low level of serum ionized calcium, its level being 1,05 mmol/l and less. The Drug-induced management of such patients included prescribing osteogenon in their preoperative period which resulted in 12,61% calcium levels increase within 2 months of osteogenon taking. Thus, adding osteogenon to severe periodontitis combination therapy leads to ionized calcium low level recovery in patients’ serum, bene ts bone regeneration and clinical stabilization of periodontal tissues process due to this medicine active components: hydroxyl apatite and ossein, represented by different growth factors, having a direct impact on bone tissue. </span></p>

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