Growth arrest-specific 5 (GAS5) insertion/deletion polymorphism and cancer susceptibility in Asian populations

Background. Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is inevitable in EGFR-mutant non-small-cell lung cancer (NSCLC) patients. A germline 2903 bp deletion polymorphism of Bcl-2-like protein 11 (BIM) causes reduced expression of proapoptotic BH3-only BIM protein and blocks TKI-induced apoptosis of tumor cells. Yet the association between the deletion polymorphism and response to EGFR-TKI treatment remains inconsistent among clinical observations. Thus, we performed the present meta-analysis. Methods. Eligible studies were identified by searching PubMed, Embase, and ClinicalTrials.gov databases prior to March 31, 2021. Hazard ratios (HRs) and 95% confidence intervals (CIs) of progression-free survival (PFS) and overall survival (OS) and odds ratios (ORs) and 95% CIs of objective response rate (ORR) and disease control rate (DCR) were calculated by using a random effects model. Sensitivity, metaregression, and publication bias analyses were also performed. Results. A total of 20 datasets (3003 EGFR-mutant NSCLC patients receiving EGFR-TKIs from 18 studies) were included. There were 475 (15.8%) patients having the 2903-bp intron deletion of BIM and 2528 (84.2%) wild-type patients. BIM deletion predicted significantly shorter PFS ( HR = 1.35 , 95% CI: 1.10-1.64, P = 0.003 ) and a tendency toward an unfavorable OS ( HR = 1.22 , 95% CI: 0.99-1.50, P = 0.068 ). Patients with deletion polymorphism had lower ORR ( OR = 0.60 , 95% CI: 0.42-0.85, P = 0.004 ) and DCR ( OR = 0.59 , 95% CI: 0.38-0.90, P = 0.014 ) compared with those without deletion. Conclusion. BIM deletion polymorphism may confer resistance to EGFR-TKIs and can be used as a biomarker to predict treatment response to EGFR-TKIs in EGFR-mutant NSCLC patients from Asian populations.

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rs401681 and rs402710 confer lung cancer susceptibility by regulating TERT expression instead of CLPTM1L in East Asian populations

Carcinogenesis ◽

10.1093/carcin/bgy084 ◽

2018 ◽

Vol 39 (10) ◽

pp. 1216-1221 ◽

Cited By ~ 1

Author(s):

Yu-Chen Yang ◽

Wei-Ping Fu ◽

Jing Zhang ◽

Li Zhong ◽

Shao-Xi Cai ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Susceptibility ◽

East Asian ◽

Asian Populations ◽

Tert Expression ◽

Lung Cancer Susceptibility

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Glutathione S-transferase T1 null genotype is associated with oral cancer susceptibility in Asian populations

Tumor Biology ◽

10.1007/s13277-013-0713-3 ◽

2013 ◽

Vol 34 (3) ◽

pp. 1753-1757 ◽

Cited By ~ 4

Author(s):

Gang Dong ◽

Yan Tian ◽

Shulan Chen ◽

Xin Xu ◽

Jianjin Zheng ◽

...

Keyword(s):

Oral Cancer ◽

Cancer Susceptibility ◽

Glutathione S Transferase ◽

Asian Populations

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Assessment of the Association between ZBTB20 rs9841504 Polymorphism and Gastric and Esophageal Cancer Susceptibility: A Meta-Analysis

The International Journal of Biological Markers ◽

10.5301/jbm.5000231 ◽

2017 ◽

Vol 32 (1) ◽

pp. 96-101 ◽

Cited By ~ 2

Author(s):

Jizhou Shi ◽

Wanzhen Li ◽

Xiping Ding

Keyword(s):

Gastric Cancer ◽

Esophageal Cancer ◽

Protective Factor ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Transcriptional Repressors ◽

Case Control Studies ◽

Asian Populations ◽

Independent Case ◽

Allele Contrast

Background The protein encoded by ZBTB20 is a member of the POK family, whose members function as transcriptional repressors through interactions mediated by their conserved C2H2 Krüppel-type zinc finger and BTB/POZ domains. Polymorphisms in ZBTB20 appeared to be associated with gastric and esophageal cancer susceptibility in biological models, but the results of these studies were inconclusive. Therefore, we conducted a meta-analysis by pooling all available data to assess the exact association between the ZBTB20 rs9841504 polymorphism and gastric and esophageal cancer susceptibility. Method The meta-analysis was performed for homozygote comparison, heterozygote comparison, and dominant and recessive models by applying a fixed- or random-effects model. The pooled odds ratios (ORs) with the corresponding confidence intervals (CIs) were calculated. Moreover, the data were analyzed using the Stata 12.0 software(StataCorp). Result A total of 8 independent case-control studies comprising 9,994 cases and 10,258 controls were included. We found a significant association between the rs9841504 polymorphism and decreased gastric cancer susceptibility in the allelic, homozygous, dominant and recessive models (B vs. A:OR = 0.797, 95% CI 0.644-0.986, p = 0.036; BB vs. AA:OR = 0.601, 95% CI 0.366-0.988, p = 0.045; BA + BB vs. AA:OR = 0.789, 95% CI 0.627-0.992, p = 0.043; BB vs. BA + AA:OR = 0.635, 95% CI 0.405-0.997, p = 0.049). Conversely, no association between the rs9841504 polymorphism and esophageal cancer susceptibility was found. In subgroup analysis by ethnicity, we observed a significantly decreased susceptibility to gastric cancer in Asian populations in the allele contrast, homozygous and recessive models (B vs. A:OR = 0.791, 95% CI 0.628-0.996, p = 0.046; BB vs. AA:OR = 0.559, 95% CI 0.323-0.966, p = 0.037; BB vs. BA + AA:OR = 0.593, 95% CI 0.361-0.972, p = 0.038). Conclusions In summary, our work suggests that the ZBTB20 rs9841504 polymorphism is a protective factor for gastric cancer rather than esophageal cancer.

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