Effectiveness of sentinel lymph node scintigraphy and intraoperative gamma probing with gold standard elective neck dissection in patients with N0 oral squamous cell cancers

2019 ◽  
Vol 40 (11) ◽  
pp. 1138-1147 ◽  
Author(s):  
Palaniswamy Shanmuga Sundaram ◽  
Padma Subramanyam
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Gold Standard ◽  
Elective Neck Dissection

scholarly journals Sentinel Lymph Node Biopsy for Early Oral Cavity Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Rajith Mendis ◽  
Muzib Abdul-Razak
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Lymph Node Biopsy ◽  
Elective Neck Dissection

Early stage oral cavity squamous cell carcinoma (OCSCC) has a significant risk of subclinical nodal metastases, which is the strongest independent prognostic factor for regional recurrence and survival. However current preoperative imaging modalities are unable to identify patients with micrometastases, and an observation strategy has been associated with inferior outcomes when compared to an elective neck dissection. Sentinel lymph node biopsy provides a safe and accurate staging procedure to select the patients who benefit from an elective neck dissection, while avoiding unnecessary surgery in the patients who are node negative. There is recent Level II evidence demonstrating equivalent oncological outcomes when compared with elective neck dissection. However, a multidisciplinary approach is required including reliable mapping of the sentinel lymph node, precise surgical technique and comprehensive histopathological analysis to ensure accurate results are obtained.

Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Stage I to II Oral Cavity Cancer

2018 ◽  
Vol 129 (1) ◽  
pp. 162-169 ◽  
Author(s):  
John D. Cramer ◽  
Shaum Sridharan ◽  
Robert L. Ferris ◽  
Umamaheswar Duvvuri ◽  
Sandeep Samant
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Oral Cavity ◽  
Neck Dissection ◽  
Oral Cavity Cancer ◽  
Lymph Node Biopsy ◽  
Stage I ◽  
Elective Neck Dissection ◽  
Node Biopsy

scholarly journals Feasibility of sentinel lymph node detection by near-infrared endoscopy in squamous cell carcinoma of the oral cavity: a pilot study

2020 ◽  
Author(s):  
Matti Sievert ◽  
Miguel Goncalves ◽  
Markus Eckstein ◽  
Heinrich Iro ◽  
Michael Koch
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Near Infrared ◽  
Elective Neck Dissection ◽  
Fluorescence Signal ◽  
Nir Fluorescence

Abstract Background Near-Infrared (NIR) fluorescence imaging is a novel technique for intraoperative sentinel lymph node (SLN) identification. It has demonstrated promising results in several surgical specialties. The study aims to evaluate the feasibility of identifying the SLN by indocyanine green (ICG) enhanced NIR endoscopy in squamous cell carcinoma of the oral cavity (OCSCC). Methods Five patients with (cT1-3N0) OCSCC were included. We injected 1–1.25 ml of ICG (5 mg/ml) at four to five points around the primary. After the elevation of a platysma flap and posterior retraction of the sternocleidomastoid muscle, fluorescence images were taken with the IMAGE1 S™ NIR/ICG system to define the SLN(s). We sampled fluorescence marked SLN(s) stratified to lymph node levels, followed by level-specified elective neck dissection. Results The detection of at least one uni- or bilateral SLN (range 1–4) was possible in every case. The fluorescence signal occurred, on average, 4.8 ± 2.6 minutes after injection. There was no case of neck metastasis in SLN (0/13) and non-SLN (0/189). No adverse reactions to ICG occurred. Conclusions Our first results are confirming the concept of SLN concerning OCSCC after the application of real-time NIR fluorescence endoscopy. However, this has to be verified by more extended studies.

scholarly journals Sentinel lymph node biopsy in early oral cavity tumors: evaluation of the oncologic efficacy compared to elective neck dissection

2018 ◽  
Vol 47 (1) ◽  
Author(s):  
Marco Roberto Seferin ◽  
Fábio Roberto Pinto ◽  
Chin Shien Lin ◽  
Ana Kober Nogueira Leite ◽  
Paulo Vitor Sola Gimenes ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Oral Cavity ◽  
Neck Dissection ◽  
Lymph Node Biopsy ◽  
Elective Neck Dissection ◽  
Node Biopsy

scholarly journals Recent Developments of ICG-Guided Sentinel Lymph Node Mapping in Oral Cancer

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 891
Author(s):  
Ji-Hoon Kim ◽  
Minhee Ku ◽  
Jaemoon Yang ◽  
Hyung Kwon Byeon
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Oral Cancer ◽  
Neck Dissection ◽  
Sentinel Lymph Node Mapping ◽  
Surgical Oncology ◽  
Elective Neck Dissection ◽  
Accurate Identification ◽  
Lymph Node Mapping ◽  
Recent Developments

Sentinel lymph node (SLN) biopsy has gained attention as a method of minimizing the extent of neck dissection with a similar survival rate as elective neck dissection in oral cancer. Indocyanine green (ICG) imaging is widely used in the field of surgical oncology. Real-time ICG-guided SLN imaging has been widely used in minimally invasive surgeries for various types of cancers. Here, we provide an overview of conventional SLN biopsy and ICG-guided SLN mapping techniques for oral cancer. Although ICG has many strengths, it still has limitations regarding its potential use as an ideal compound for SLN mapping. The development of novel fluorophores and imaging technology is needed for accurate identification of SLNs, which will allow precision surgery that would reduce morbidities and increase patient survival.

Gamma Probe Accuracy in Detecting the Sentinel Lymph Node in Clinically No Squamous Cell Carcinoma of the Head and Neck

2002 ◽  
Vol 111 (9) ◽  
pp. 794-798 ◽  
Author(s):  
Sandro Sulfaro ◽  
Wally Marus ◽  
Luigi Barzan ◽  
Fulvio Alberti ◽  
Marco Pin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Node ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Primary Tumor ◽  
Tumor Spread

The sentinel node, which is not always located at the first-echelon nodal area close to the primary tumor, is the initial recipient of possible metastasis. In order to verify the usefulness of the sentinel lymph node technique in the staging of head and neck cancers, we studied 31 untreated patients with squamous cell carcinoma of the upper airways by injecting them around the primary tumor with technetium 99m albumin microcolloid (99mTc) and submitting them to selective neck dissection with en bloc tumor removal. The nodes were examined after γ-probe identification of the sentinel node(s). No patients were found to have microscopic tumor spread outside the level(s) containing the γ-probe-identified sentinel node(s). In only 1 case was the metastatic node not the γ-probe-posi-tive one, but an adjacent one. Lymphoscintigraphy with 99mTc seems reliable in identifying the sentinel node(s) and might contribute to the reduction of surgical morbidity by reserving therapeutic neck dissection for cases with histologically confirmed nodal metastasis.

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