scholarly journals Mortality, AIDS-Morbidity, and Loss to Follow-up by Current CD4 Cell Count Among HIV-1–Infected Adults Receiving Antiretroviral Therapy in Africa and Asia

2013 ◽  
Vol 62 (5) ◽  
pp. 555-561 ◽  
Author(s):  
Delphine Gabillard ◽  
Charlotte Lewden ◽  
Ibra Ndoye ◽  
Raoul Moh ◽  
Olivier Segeral ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Cd4 Cell Count ◽  
Loss To Follow Up ◽  
Cd4 Cell ◽  
Hiv 1

scholarly journals Early Postseroconversion CD4 Cell Counts Independently Predict CD4 Cell Count Recovery in HIV-1–Postive Subjects Receiving Antiretroviral Therapy

2011 ◽  
Vol 57 (5) ◽  
pp. 387-395 ◽  
Author(s):  
Hemant Kulkarni ◽  
Jason F Okulicz ◽  
Greg Grandits ◽  
Nancy F Crum-Cianflone ◽  
Michael L Landrum ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Cd4 Cell Count ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Cd4 Cell ◽  
Hiv 1 ◽  
Count Recovery

scholarly journals Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy

AIDS ◽  
2014 ◽  
Vol 28 (8) ◽  
pp. 1193-1202 ◽  
Author(s):  
Margaret T. May ◽  
Mark Gompels ◽  
Valerie Delpech ◽  
Kholoud Porter ◽  
Chloe Orkin ◽  
...  
Keyword(s):  
Viral Load ◽  
Antiretroviral Therapy ◽  
Life Expectancy ◽  
Cell Count ◽  
Cd4 Cell Count ◽  
Load Response ◽  
Cd4 Cell ◽  
Hiv 1 ◽  
Viral Load Response

Transmitted Drug Resistant HIV-1 and Association With Virologic and CD4 Cell Count Response to Combination Antiretroviral Therapy in the EuroSIDA Study

2008 ◽  
Vol 48 (3) ◽  
pp. 324-333 ◽  
Author(s):  
Wendy P Bannister ◽  
Alessandro Cozzi-Lepri ◽  
Bonaventura Clotet ◽  
Amanda Mocroft ◽  
Jesper Kjær ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Drug Resistant ◽  
Combination Antiretroviral Therapy ◽  
Cd4 Cell Count ◽  
Count Response ◽  
Cd4 Cell ◽  
Hiv 1 ◽  
Eurosida Study

scholarly journals Multilevel model on longitudinal data analysis in determinants of cd4 cell count among antiretroviral therapy attendant of hiv infected adults follow up in gondar teaching referral hospital, Gonder, Ethiopia.

2020 ◽  
Author(s):  
Kindu Kebede
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Multilevel Model ◽  
Immune Cell ◽  
Hemoglobin Level ◽  
Referral Hospital ◽  
Sub Saharan Africa ◽  
Cd4 Cell Count ◽  
Cd4 Cell

Abstract Background: Human immunodeficiency virus attacked an immune cell and the CD4 cell which is responsible for the body’s immune to infectious agents. Acquired immunodeficiency syndrome is one of the major public health problems in Sub-Saharan Africa including Ethiopia. The main objective of this study to identify the determinants of CD4 cell count among antiretroviral therapy attendants of infected adults follow up in Gonder teaching referral hospital, Gonder, Ethiopia implemented by SAS version 94. Methods: A retrospective cohort study was conducted on 216 regular follow up patients whose age greater than 14 years from December 1, 2012, to December 30, 2017. A multilevel model was used to identify the factors of CD4 cell count of patients and it considered variability between and within patients. Results: The mean with a standard deviation of weight, and a hemoglobin level of patients were 55.48(10.21), and 18.25(33.028) respectively. This study concluded that the variation for CD4 cell count existed between patients was 63 % and the remaining 37 % of variation existing within patients. In this study, the random coefficient time-varying covariate model was well fitted which shows weight and hemoglobin level were statistically significant predictors at a 5% level of significance for the log of CD4 cell count of patients. Conclusion: This study shows the hemoglobin level and weight of patients were statistically significant for the log of CD4 cell count of patients follow up in Gonder teaching referral hospital, Gonder, Ethiopia. Moreover, the result of the study shows that the log of CD4 count of patients increased when hemoglobin level and weight of patients increased. Hence, intervention should be given the ways to increase weight and hemoglobin levels of patients during follow up antiretroviral therapy.

Futility of CD4+ monitoring in HIV-1 patients with CD4+ cell count above 350 cells/μl on suppressive antiretroviral therapy

AIDS ◽  
2014 ◽  
Vol 28 (17) ◽  
pp. 2638-2639 ◽  
Author(s):  
Christopher J.A. Duncan ◽  
Matthias L. Schmid ◽  
Ulrich Schwab ◽  
David A. Price ◽  
Edmund Ong
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Cd4 Cell Count ◽  
Cd4 Cell ◽  
Hiv 1

Outcomes following detection of low level plasma HIV RNA in HIV-infected patients previously virologically suppressed on antiretroviral therapy: a retrospective observational study

Sexual Health ◽  
2017 ◽  
Vol 14 (3) ◽  
pp. 238
Author(s):  
Annabelle M. Warren ◽  
Allen C. Cheng ◽  
Kerrie Watson ◽  
Sharon R. Lewin ◽  
Jennifer F. Hoy
Keyword(s):  
Type 2 Diabetes ◽  
Antiretroviral Therapy ◽  
Cell Count ◽  
Virological Suppression ◽  
Cd4 Cell Count ◽  
Factors Associated ◽  
Hiv Rna ◽  
Cd4 Cell

Background: Progressively sensitive assays for plasma HIV RNA have led to increased detection of plasma HIV RNA between 20 and 200 copies/ml, known as low level viremia (LLV) when recurrent or persistent, in HIV-infected patients on antiretroviral therapy (ART). The aim of this study was to determine outcomes following initial detection of LLV in an Australian cohort. Methods: A retrospective study using the HIV Service Database (Alfred Hospital) included all patients on ART who recorded plasma HIV RNA 20–200 copies/mL following prior virological suppression (viral load (VL) HIV RNA <20 copies/mL) over 2 years (2010 to 2012), with follow-up to June 2013. Factors associated with subsequent virological outcome were assessed via univariate and multivariate analysis. Results: Of 919 patients managed by The Alfred HIV service, 207 (22.5%) met inclusion criteria. Mean age was 48.8 years, 91.3% were male. During follow-up, 54% patients recorded no further HIV RNA 20–200 copies/mL (viral blip); 39% had recurrent or persistent VL 20–200 copies/mL (LLV); and 7% progressed to virological failure with VL >200 copies/mL. Factors associated with LLV included co-morbid type 2 diabetes, shorter prior virological suppression and lower nadir CD4 cell count. Clinician management of VL 20–200 copies/mL was generally conservative, with infrequent requests for genotypic analysis (3.3% cases) or change in ART (<1% cases). Conclusions: LLV following virological suppression is common, and occurred as an isolated viral blip in half the patients. Those patients with persistent or recurrent LLV had higher rates of type 2 diabetes, shorter prior virological suppression and lower nadir CD4 cell count.

scholarly journals Mortality and loss to follow up before initiation of antiretroviral therapy among HIV-infected children eligible for HIV treatment

2014 ◽  
Vol 6 (2) ◽  
Author(s):  
Gerardo Alvarez-Uria ◽  
Praveen Kumar Naik ◽  
Manoranjan Midde ◽  
Raghavakalyan Pakam
Keyword(s):  
Antiretroviral Therapy ◽  
Multivariable Analysis ◽  
Hiv Treatment ◽  
Attrition Rate ◽  
Older Children ◽  
Cd4 Cell Count ◽  
Loss To Follow Up ◽  
Art Initiation ◽  
Cd4 Cell

Data on attrition due to mortality or loss to follow-up (LTFU) from antiretroviral therapy (ART) eligibility to ART initiation of HIV-infected children are scarce. The aim of this study is to describe attrition before ART initiation of 247 children who were eligible for ART in a cohort study in India. Multivariable analysis was performed using competing risk regression. The cumulative incidence of attrition was 12.6% (95% confidence interval, 8.7-17.3) after five years of follow-up, and the attrition rate was higher during the first months after ART eligibility. Older children (&gt;9 years) had a lower mortality risk before ART initiation than those aged &lt;2 years. Female children had a lower risk of LTFU before ART initiation than males. Children who belonged to scheduled tribes had a higher risk of delayed ART initiation and LTFU. Orphan children had a higher risk of delayed ART initiation and mortality. Children who were &gt;3 months in care before ART eligibility were less likely to be LTFU. The 12-month risk of AIDS, which was calculated using the absolute CD4 cell count and age, was strongly associated with mortality. A substantial proportion of ART-eligible children died or were LTFU before the initiation of ART. These findings can be used in HIV programmes to design actions aimed at reducing the attrition of ART-eligible children in India.

Impact of 5 years of maximally successful highly active antiretroviral therapy on CD4 cell count and HIV-1 DNA level

AIDS ◽  
2004 ◽  
Vol 18 (1) ◽  
pp. 45-49 ◽  
Author(s):  
Jean-Paul Viard ◽  
Marianne Burgard ◽  
Jean-Baptiste Hubert ◽  
Laurent Aaron ◽  
Cécile Rabian ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Highly Active Antiretroviral Therapy ◽  
Cd4 Cell Count ◽  
Highly Active ◽  
Cd4 Cell ◽  
Hiv 1

scholarly journals Development and Validation of Decision Rules to Guide Frequency of Monitoring CD4 Cell Count in HIV-1 Infection before Starting Antiretroviral Therapy

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
pp. e18578 ◽  
Author(s):  
Thierry Buclin ◽  
Amalio Telenti ◽  
Rafael Perera ◽  
Chantal Csajka ◽  
Hansjakob Furrer ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Decision Rules ◽  
Cd4 Cell Count ◽  
Development And Validation ◽  
Cd4 Cell ◽  
Hiv 1
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