68Ga-FAPI PET/CT Improves Therapeutic Strategy by Detecting a Second Primary Malignancy in a Patient With Rectal Cancer

Hodgkin lymphoma is an uncommon neoplasm that characterized young age of onset, Hodgkin and Reed-Sternberg (HRS) cells derived from B-lymphocytes and a high cure rate, even when the patient presents with advanced metastatic spread. Lung cancer is the most common cancer worldwide and is still responsible for the most cancer deaths. We present an extremely rare case of coexisting Hodgkin lymphoma and lung cancer in a 67-year-old male patient. He initially presented with chest pain. Pet/ct revealed mass in the right lung and lymph nodes in the neck. Biopsy from the premaxillary lymph node was compatible with classical Hodgkin lymphoma. In terms of second primary malignancy, a biopsy was also performed from the mass in the right lung. Pathology showed a pulmonary adenocarcinoma and a right upper lobectomy was then performed. This patient was treated with gemcitabine plus docetaxel for lung cancer. At the end of treatment pet/ct was complete response including lymph nodes in the neck. Therefore, we did not give any treatment for Hodgkin lymphoma. The patient is still being followed up in remission.

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The clinical significance of 18F-FDG-PET/CT in early detection of second primary malignancy in cancer patients

Journal of Cancer Research and Clinical Oncology ◽

10.1007/s00432-010-0759-1 ◽

2010 ◽

Vol 136 (8) ◽

pp. 1125-1134 ◽

Cited By ~ 5

Author(s):

Haoping Xu ◽

Miao Zhang ◽

Ge Zhai ◽

Biao Li

Keyword(s):

Early Detection ◽

Cancer Patients ◽

Clinical Significance ◽

Fdg Pet ◽

Second Primary ◽

Second Primary Malignancy ◽

Primary Malignancy ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Preoperative Short-Course Radiotherapy and Surgery versus Surgery Alone for Patients with Rectal Cancer: A Propensity Score-Matched Analysis at 18-Year Follow-Up

Biomedicines ◽

10.3390/biomedicines9070725 ◽

2021 ◽

Vol 9 (7) ◽

pp. 725

Author(s):

Radoslaw Pach ◽

Piotr Richter ◽

Marek Sierzega ◽

Natalia Papp ◽

Antoni Szczepanik

Keyword(s):

Rectal Cancer ◽

Preoperative Radiotherapy ◽

Locally Advanced ◽

Advanced Rectal Cancer ◽

Locally Advanced Rectal Cancer ◽

Second Primary ◽

Second Primary Malignancy ◽

Primary Malignancy ◽

Radiotherapy Group ◽

Short Course

A significant problem for long-term rectal cancer survivors may be the late toxicity of radiotherapy. It creates the possible risk of developing second primary malignancy and a theoretical decrease in overall survival. This study aimed to assess the influence of short-course preoperative radiotherapy in patients with locally advanced rectal cancer on overall survival, local recurrence rate, and second malignancy at 18-year follow-up. The rectal cancer trial was conducted in a single tertiary center between February 1992 and June 2006. A total of 389 patients with locally advanced rectal cancer (cT2-cT4, cN0/+, cM0) were included in the study. Preoperative radiotherapy was conducted in 148 patients and 241 patients underwent surgery alone. The propensity-matched group consisted of 105 patients operated on after radiotherapy and 105 controls. The number of local recurrences was 7 (6.7%) in the preoperative radiotherapy group and 22 (21%) in the surgery alone group (p = 0.016). The 18-year survival analysis showed no survival benefit in the preoperative radiotherapy group (38% versus 48%, p = 0.107) but improved recurrence-free survival (81% versus 58%, p = 0.001). The preoperative short-course radiotherapy significantly decreases the risk of local recurrence in locally advanced rectal cancer and may improve recurrence-free survival without an increased risk of second primary malignancy.

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