scholarly journals Tacrolimus Trough Concentration Variability and Disparities in African American Kidney Transplantation

2017 ◽  
Vol 101 (12) ◽  
pp. 2931-2938 ◽  
Author(s):  
David J. Taber ◽  
Zemin Su ◽  
James N. Fleming ◽  
John W. McGillicuddy ◽  
Maria A. Posadas-Salas ◽  
...  
Keyword(s):  
African American ◽  
Kidney Transplantation ◽  
Trough Concentration ◽  
Tacrolimus Trough Concentration

scholarly journals A Novel, Dose-Adjusted Tacrolimus Trough-Concentration Model for Predicting and Estimating Variance After Kidney Transplantation

Drugs in R&D ◽  
2019 ◽  
Vol 19 (2) ◽  
pp. 201-212 ◽  
Author(s):  
Janet Kim ◽  
Sam Wilson ◽  
Nasrullah A. Undre ◽  
Fei Shi ◽  
Rita M. Kristy ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Trough Concentration ◽  
Tacrolimus Trough Concentration

scholarly journals Predictors of Adverse Events and Determinants of the Voriconazole Trough Concentration in Kidney Transplantation Recipients

2020 ◽  
Author(s):  
Yi‐Chang Zhao ◽  
Xiao‐Bin Lin ◽  
Bi‐Kui Zhang ◽  
Yi‐wen Xiao ◽  
Ping Xu ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Adverse Events ◽  
Trough Concentration

scholarly journals P1706THE GRAFT SURVIVAL OF KIDNEY TRANSPLANTATION ACCORDING TO ETHNICITY IN KIDNEY TRANSPLANT RECIPIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Yeonsoon Jung ◽  
Jisu Kim ◽  
Haesu Jeon ◽  
Ye Na Kim ◽  
Ho Sik Shin ◽  
...  
Keyword(s):  
African American ◽  
Kidney Transplantation ◽  
Kidney Transplant ◽  
Graft Survival ◽  
Cox Regression ◽  
Patient Survival ◽  
Graft Loss ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Data Set

Abstract Background African American kidney transplant recipients experience disproportionately high rates of graft loss. The aim of this analysis was to use a UNOS data set that contains detailed baseline and longitudinal clinical data to establish and quantify the impact of the current overall graft loss definition on suppressing the true disparity magnitude in US AA kidney transplant outcomes. Methods Longitudinal cohort study of kidney transplant recipients using a data set created by United Network for Organ Sharing (UNOS), including 266,128 (African American 70,215, Non-African American 195,913) transplant patient between 1987 and December 2016. Multivariable analysis was conducted using 2-stage joint modeling of random and fixed effects of longitudinal data (linear mixed model) with time to event outcomes (Cox regression). Results 195,913 non-African American (AA) (73.6%) were compared with 70,215 AA (26.4%) recipients. 10-year-graft survival of AA in all era is lower than that of non-AA (31% in deceased kidney transplants (DKT) AA recipient and 42% in living kidney transplantation (LKT) non-AA recipient). 10-year-patient survival of AA with functioning graft in all era is similar that of non-AA. Multivariate Cox regression of factors associated with patient survival with functioning graft are acute rejection within 6 months, DM, hypertension and etc. Pre-transplant recipient BMI in AA show the trend as a protective factor in patient survival with functioning graft although not significantly in statistics Conclusions African American kidney transplant recipients experience a substantial disparity in graft loss, but not patient death with functioning graft.

AFRICAN AMERICAN RACE AS A RISK FACTOR IN OUTCOMES AFTER SECOND AND THIRD KIDNEY TRANSPLANTATION

2010 ◽  
Vol 90 ◽  
pp. 73
Author(s):  
J. McGee ◽  
L. P. Chou ◽  
A. Harbin ◽  
Y. Hsueh ◽  
C. L. Yau ◽  
...  
Keyword(s):  
African American ◽  
Risk Factor ◽  
Kidney Transplantation ◽  
African American Race

Preferences, Knowledge, Communication and Patient-Physician Discussion of Living Kidney Transplantation in African American Families

2005 ◽  
Vol 5 (6) ◽  
pp. 1503-1512 ◽  
Author(s):  
L. Ebony Boulware ◽  
Lucy A. Meoni ◽  
Nancy E. Fink ◽  
Rulan S. Parekh ◽  
W. H. Linda Kao ◽  
...  
Keyword(s):  
African American ◽  
Kidney Transplantation ◽  
African American Families ◽  
Knowledge Communication ◽  
American Families

scholarly journals Massive Leiomyomatous Uterine Proliferation Following Kidney Transplantation: A Case Report and Literature Review

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Emmanuel J. Minja ◽  
Miguel Tan ◽  
Melissa J. Gibbs ◽  
Marwan M. Kazimi ◽  
Jonathan C. Hundley ◽  
...  
Keyword(s):  
African American ◽  
Kidney Transplantation ◽  
Literature Review ◽  
Perioperative Management ◽  
Lateral Displacement ◽  
Uterine Fibroids ◽  
Tube Placement ◽  
Management Guidelines ◽  
Uterine Tumors ◽  
Tract Infections

Uterine fibroids are the most common benign uterine tumors affecting > 50% of premenopausal women. The incidence, burden and symptoms from uterine fibroids are higher in women of African descent compared to Caucasians. Despite increasing number of African American females being evaluated for and undergoing kidney transplantation (KT), perioperative management guidelines for uterine fibroids currently do not exist. We present a case of a 40 y/o African American female with known symptomatic uterine fibroids preoperatively and medically managed, who underwent a successful KT and 4 years later progressively developed massive leiomyomatous uterine proliferation, causing a complete lateral displacement of the transplanted kidney with severe hydronephrosis, transplant ureteral obstruction and secondary urinary tract infections with bacteremia. This obstruction required a percutaneous nephrostomy tube placement followed by an interval transabdominal hysterectomy, which was complicated by transplant ureteral transection requiring ureteral reimplantation, resulting in prolonged hospitalization, follow-up and outpatient antibiotic regimen. There is a need for management guidelines for uterine fibroids incidentally encountered during the KT evaluation process to avoid similar preventable post-KT complications in patient populations most commonly affected. Literature review and perioperative management/surveillance strategies are provided.

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