scholarly journals Development and Application of a Semi quantitative Scoring Method for Ultrastructural Assessment of Acute Stress in Pancreatic Islets

2021 ◽  
Vol 8 (1) ◽  
pp. e1271
Author(s):  
Nicola J. Dyson ◽  
Nicole Kattner ◽  
Minna Honkanen-Scott ◽  
Bethany Hunter ◽  
Jennifer A. Doyle ◽  
...  
Keyword(s):  
Pancreatic Islets ◽  
Acute Stress ◽  
Scoring Method ◽  
Quantitative Scoring

scholarly journals High Prevalence of 5T4/Trophoblast Glycoprotein in Soft Tissue Sarcomas

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4841
Author(s):  
Patrick Groothuis ◽  
Nicola Penel ◽  
Antoine Italiano ◽  
Nuria Kotecki ◽  
Fred Dijcks ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tumor Tissue ◽  
Staining Method ◽  
Soft Tissue Sarcomas ◽  
Tissue Microarrays ◽  
Histological Subtypes ◽  
Scoring Method ◽  
Drug Conjugates ◽  
High Prevalence ◽  
Quantitative Scoring

The expression of 5T4/trophoblast glycoprotein was evaluated in several histological subtypes of soft tissue sarcoma (STS) to determine whether the prevalence and level of expression of this membrane-associated glycoprotein is sufficient for use in targeted therapies. Tumor tissue microarrays containing cores from different histological subtypes of STS were stained using a standardized immunohistochemical staining method to detect 5T4; the level of staining was assessed using a semi-quantitative scoring method. No 5T4 staining was seen in the angiosarcomas and liposarcomas investigated in this study. 5T4 staining in the other STS subtypes was seen in more than 50% of cases, warranting further investigation into whether this antigen could evoke an anti-tumor immune response or can be used as target for the delivery of more potent toxins through antibody drug conjugates.

scholarly journals Visual field deficits after epilepsy surgery: a new quantitative scoring method

2018 ◽  
Vol 160 (7) ◽  
pp. 1325-1336 ◽  
Author(s):  
Rick H. G. J. van Lanen ◽  
M. C. Hoeberigs ◽  
N. J. C. Bauer ◽  
R. H. L. Haeren ◽  
G. Hoogland ◽  
...  
Keyword(s):  
Visual Field ◽  
Epilepsy Surgery ◽  
Scoring Method ◽  
Visual Field Deficits ◽  
Quantitative Scoring

Endocervical glandular lesions: A diagnostic approach combining a semi-quantitative scoring method to the expression of CEA, MIB-1 and p16

2006 ◽  
Vol 103 (3) ◽  
pp. 971-976 ◽  
Author(s):  
K. Pavlakis ◽  
I. Messini ◽  
S. Athanassiadou ◽  
E. Kyrodimou ◽  
A. Pandazopoulou ◽  
...  
Keyword(s):  
Diagnostic Approach ◽  
Scoring Method ◽  
Quantitative Scoring ◽  
Mib 1

scholarly journals QUANTITATIVE APPROACH TO ASSIST NEUROBLASTOMA ASSESSMENT BY MEASURING I-123 mIBG UPTAKE IN SCINTIGRAPHIC IMAGES

2015 ◽  
Vol 34 (2) ◽  
pp. 135 ◽  
Author(s):  
Rafael Martínez-Díaz ◽  
Julia Balaguer ◽  
Luis Manuel Sánchez-Ruiz ◽  
Pilar Bello ◽  
Victoria Castel ◽  
...  
Keyword(s):  
Collaborative Work ◽  
Paediatric Oncology ◽  
Response To Therapy ◽  
Whole Body ◽  
Specific Method ◽  
Scoring Method ◽  
Additional Tool ◽  
Primary Image ◽  
Specific Uptake ◽  
Quantitative Scoring

Whole-body 123I-Metaiodobenzylguanidine (mIBG) scintigraphy is used as the primary image modality in neuroblastoma detection. It is the most sensitive and specific method for staging and response evaluation. Validated semi-quantitative scoring methods with low interobserver variability and high reproducibility have shown to be indispensable for the evaluation of response to therapy. However, low resolution, noise and acquisition difficulties, specially in children, make low definition scans. These facts increase observer dependent interpretations that limit assessment and complicate to put a scoring method successfully into practice. It is essential to have an objective and reliable measure of response to test the activity of therapies. In this paper we propose the use of a quantitative observer-independent measurement of the strength of uptake to be used as an additional tool for assisting the International Society of Paediatric Oncology Europe Neuroblastoma Group (SIOPEN) semi-quantitative scoring method. This is the scoring method recommended by the SIOPEN Nuclear Medicine and Physics Committee, in collaborative work with the Children’s Oncology Group, as the standard one for acquiring and reporting diagnostic paediatric mIBG scans across Europe. Our proposed method is based on the ratio between the amount of specific uptake at tumours and the amount of non-specific uptake at SIOPEN anatomical sectors which has shown to be constant in all the scans of the patients.

scholarly journals DEVELOPMENT OF A QUANTITATIVE SCORING METHOD FOR STROBE CHECKLIST

2018 ◽  
Vol 75 (5) ◽  
pp. 1095-1106 ◽  
Author(s):  
Dnyanesh Limaye ◽  
Vaidehi Limaye ◽  
Ravi Shankar Pitani ◽  
Gerhard Fortwengel ◽  
Arlan Sydymanov ◽  
...  
Keyword(s):  
Scoring Method ◽  
Quantitative Scoring

scholarly journals Qualitative analysis and identification of pattern of errors in Clock Drawing Tests of community-dwelling older adults

2018 ◽  
Vol 12 (2) ◽  
pp. 181-188
Author(s):  
Barbara Spenciere ◽  
Liana Chaves Mendes-Santos ◽  
Christina Borges-Lima ◽  
Helenice Charchat-Fichman
Keyword(s):  
Older Adults ◽  
Linear Regression ◽  
Scoring Systems ◽  
Hierarchical Cluster ◽  
Community Dwelling ◽  
Scoring Method ◽  
Error Patterns ◽  
Clock Drawing Test ◽  
Clock Drawing ◽  
Quantitative Scoring

Abstract The Clock Drawing Test (CDT) is a frequently employed screening tool with different scoring systems. Quantitative and semi-quantitative scoring systems, such as Sunderland’s et al. (1989), do not discriminate different error patterns. Thus, the same score can represent a number of different neuropsychological profiles. Therefore, the use of a scoring method that emphasizes qualitative aspects to determine specific error patterns is fundamental. Objective: To use a qualitative scale to analyze error patterns in the CDTs of older adults who scored 5 in a previous study. Methods: 49 CDTs with score of 5 were analyzed using the qualitative scale. Linear regression and hierarchical and non-hierarchical cluster analyses were performed. Results: The linear regression showed a significant association between the total score and all the error patterns of the qualitative scale. The hierarchical cluster yielded three groups. However, due to the heterogeneity observed among the groups, a non-hierarchical cluster analysis was performed to better understand the results. Three groups were determined with different neuropsychological profiles and patterns of errors. Conclusion: The qualitative scoring of the CDT is important when examining and analyzing specific neuropsychological domains in older adults, especially executive functions.

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