Regional Brain Atrophy and Impaired Decision Making on the Balloon Analog Risk Task in Behavioral Variant Frontotemporal Dementia

2011 ◽  
Vol 24 (2) ◽  
pp. 59-67 ◽  
Author(s):  
Maren Strenziok ◽  
Sarah Pulaski ◽  
Frank Krueger ◽  
Giovanna Zamboni ◽  
Deborah Clawson ◽  
...  
Keyword(s):  
Decision Making ◽  
Frontotemporal Dementia ◽  
Brain Atrophy ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Regional Brain ◽  
Regional Brain Atrophy

scholarly journals Interactions between decision-making and emotion in behavioral-variant frontotemporal dementia and Alzheimer’s disease

2020 ◽  
Vol 15 (6) ◽  
pp. 681-694
Author(s):  
Aurélie L Manuel ◽  
Daniel Roquet ◽  
Ramon Landin-Romero ◽  
Fiona Kumfor ◽  
Rebekah M Ahmed ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Decision Making ◽  
Frontotemporal Dementia ◽  
Delay Discounting ◽  
Animal Studies ◽  
Negative Emotion ◽  
Emotion Processing ◽  
Brain Regions ◽  
Behavioral Variant Frontotemporal Dementia

Abstract Negative and positive emotions are known to shape decision-making toward more or less impulsive responses, respectively. Decision-making and emotion processing are underpinned by shared brain regions including the ventromedial prefrontal cortex (vmPFC) and the amygdala. How these processes interact at the behavioral and brain levels is still unclear. We used a lesion model to address this question. Study participants included individuals diagnosed with behavioral-variant frontotemporal dementia (bvFTD, n = 18), who typically present deficits in decision-making/emotion processing and atrophy of the vmPFC, individuals with Alzheimer’s disease (AD, n = 12) who present with atrophy in limbic structures and age-matched healthy controls (CTRL, n = 15). Prior to each choice on the delay discounting task participants were cued with a positive, negative or neutral picture and asked to vividly imagine witnessing the event. As hypothesized, our findings showed that bvFTD patients were more impulsive than AD patients and CTRL and did not show any emotion-related modulation of delay discounting rate. In contrast, AD patients showed increased impulsivity when primed by negative emotion. This increased impulsivity was associated with reduced integrity of bilateral amygdala in AD but not in bvFTD. Altogether, our results indicate that decision-making and emotion interact at the level of the amygdala supporting findings from animal studies.

[P3-564]: THE EFFECT OF SPIRITUALITY/RELIGIOSITY ON REGIONAL BRAIN ATROPHY IN SUBJECTS AT RISK OF ALZHEIMER DISEASE: THREE-YEAR FOLLOW-UP DATA FROM CZECH BRAIN AGING STUDY

2017 ◽  
Vol 13 (7S_Part_24) ◽  
pp. P1195-P1195
Author(s):  
Katerina Sheardova ◽  
Zuzana Nedelska ◽  
Rastislav Sumec ◽  
Rafal Marciniak ◽  
Miroslav Uller ◽  
...  
Keyword(s):  
At Risk ◽  
Alzheimer Disease ◽  
Brain Atrophy ◽  
Brain Aging ◽  
Regional Brain ◽  
Aging Study ◽  
Regional Brain Atrophy

Progressive Impairment of Decision-Making in Behavioral-Variant Frontotemporal Dementia

2013 ◽  
Vol 25 (2) ◽  
pp. E20-E21 ◽  
Author(s):  
Michele Poletti ◽  
Filippo Baldacci ◽  
Gabriele Cipriani ◽  
Angelo Nuti ◽  
Ubaldo Bonuccelli
Keyword(s):  
Decision Making ◽  
Frontotemporal Dementia ◽  
Behavioral Variant Frontotemporal Dementia

Tau Platelets Correlate with Regional Brain Atrophy in Patients with Alzheimer’s Disease

2016 ◽  
Vol 55 (4) ◽  
pp. 1595-1603 ◽  
Author(s):  
Andrea Slachevsky ◽  
Leonardo Guzmán-Martínez ◽  
Carolina Delgado ◽  
Pablo Reyes ◽  
Gonzalo A. Farías ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Atrophy ◽  
Regional Brain ◽  
Regional Brain Atrophy

P3-112: Patterns of regional brain atrophy and amyloid deposition in Alzheimer's disease

2013 ◽  
Vol 9 ◽  
pp. P593-P593
Author(s):  
Ranjan Duara ◽  
Warren Barker ◽  
David Loewenstein ◽  
Qian Shen ◽  
Maria Greig-Custo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Atrophy ◽  
Amyloid Deposition ◽  
Regional Brain ◽  
Regional Brain Atrophy
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