scholarly journals Ventrolateral and dorsomedial frontal cortex lesions impair mnemonic context retrieval

2015 ◽  
Vol 282 (1801) ◽  
pp. 20142555 ◽  
Author(s):  
Catherine Chapados ◽  
Michael Petrides
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Frontal Cortex ◽  
Temporal Lobe ◽  
Context Condition ◽  
Multiple Contexts ◽  
Dorsomedial Frontal Cortex ◽  
Prefrontal Region ◽  
The Stability ◽  
The Right

The prefrontal cortex appears to contribute to the mnemonic retrieval of the context within which stimuli are experienced, but only under certain conditions that remain to be clarified. Patients with lesions to the frontal cortex, the temporal lobe and neurologically intact individuals were tested for context memory retrieval when verbal stimuli (words) had been experienced across multiple (unstable context condition) or unique (stable context condition) contexts; basic recognition memory of these words-in-contexts was also tested. Patients with lesions to the right ventrolateral prefrontal cortex (VLPFC) were impaired on context retrieval only when the words had been seen in multiple contexts, demonstrating that this prefrontal region is critical for active retrieval processing necessary to disambiguate memory items embedded across multiple contexts. Patients with lesions to the left dorsomedial prefrontal region were impaired on both context retrieval conditions, regardless of the stability of the stimulus-to-context associations. Conversely, prefrontal lesions sparing the ventrolateral and dorsomedial regions did not impair context retrieval. Only patients with temporal lobe excisions were impaired on basic recognition memory. The results demonstrate a basic contribution of the left dorsomedial frontal region to mnemonic context retrieval, with the VLPFC engaged, selectively, when contextual relations are unstable and require disambiguation.

Anatomy of Motor Learning. I. Frontal Cortex and Attention to Action

1997 ◽  
Vol 77 (3) ◽  
pp. 1313-1324 ◽  
Author(s):  
M. Jueptner ◽  
K. M. Stephan ◽  
C. D. Frith ◽  
D. J. Brooks ◽  
R.S.J. Frackowiak ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Motor Learning ◽  
Frontal Cortex ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Critical Feature ◽  
Positron Emission ◽  
New Learning ◽  
The Right

Jueptner, M., K. M. Stephan, C. D. Frith, D. J. Brooks, R.S.J. Frackowiak, and R. E. Passingham. Anatomy of motor learning. I. Frontal cortex and attention to action. J. Neurophysiol. 77: 1313–1324, 1997. We used positron emission tomography to study new learning and automatic performance in normal volunteers. Subjects learned sequences of eight finger movements by trial and error. In a previous experiment we showed that the prefrontal cortex was activated during new learning but not during automatic performance. The aim of the present experiment was to see what areas could be reactivated if the subjects performed the prelearned sequence but were required to pay attention to what they were doing. Scans were carried out under four conditions. In the first the subjects performed a prelearned sequence of eight key presses; this sequence was learned before scanning and was practiced until it had become overlearned, so that the subjects were able to perform it automatically. In the second condition the subjects learned a new sequence during scanning. In a third condition the subjects performed the prelearned sequence, but they were required to attend to what they were doing; they were instructed to think about the next movement. The fourth condition was a baseline condition. As in the earlier study, the dorsal prefrontal cortex and anterior cingulate area 32 were activated during new learning, but not during automatic performance. The left dorsal prefrontal cortex and the right anterior cingulate cortex were reactivated when subjects paid attention to the performance of the prelearned sequence compared with automatic performance of the same task. It is suggested that the critical feature was that the subjects were required to attend to the preparation of their responses. However, the dorsal prefrontal cortex and the anterior cingulate cortex were activated more when the subjects learned a new sequence than they were when subjects simply paid attention to a prelearned sequence. New learning differs from the attention condition in that the subjects generated moves, monitored the outcomes, and remembered the responses that had been successful. All these are nonroutine operations to which the subjects must attend. Further analysis is needed to specify which are the nonroutine operations that require the involvement of the dorsal prefrontal and anterior cingulate cortex.

scholarly journals An Exploratory Study of the Relationship between Face Recognition Memory and the Volume of Medial Temporal Lobe Structures in Healthy Young Males

1998 ◽  
Vol 11 (1) ◽  
pp. 3-20 ◽  
Author(s):  
Clare E. Mackay ◽  
Neil Roberts ◽  
Andrew R. Mayes ◽  
John J. Downes ◽  
Jonathan K. Foster ◽  
...  
Keyword(s):  
Face Recognition ◽  
Recognition Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Multiple Comparisons ◽  
Cerebral Hemispheres ◽  
Parahippocampal Gyrus ◽  
Bonferroni Correction ◽  
Temporal Pole ◽  
The Right

A rigorous new methodology was applied to the study of structure function relationships in the living human brain. Face recognition memory (FRM) and other cognitive measures were made in 29 healthy young male subjects (mean age = 21.7 years) and related to volumetric measurements of their cerebral hemispheres and of structures in their medial temporal lobes, obtained using the Cavalieri method in combination with high resolution Magnetic Resonance Imaging (MRI. Greatest proportional variability in volumes was found for the lateral ventricles (57%) for the cerebral hemispheres (8%) in the mean volumes of the hippocampus, parahippocampal gyrus, amygdala, caudate nucleus, temporal pole and temporal lobe on the right and left sides of the brain. The volumes of the right and left parahippocampal gyrus, temporal pole, temporal lobe, and left hippocampus were, prior to application of the Bonferroni correction to take account of 12 multiple comparisons, significantly correlated with the volume of the corresponding hemisphere (p< 0.05). The volumes of all structures were highly correlated (p< 0.0002 for all comparisons) between the two cerebral hemispheres. There were no positive relationships between structure volumes and FRM score. However, the volume of the right amygdala was, prior to application of the Bonferroni correction to take account of 38~multiple comparisons, found to be significantly smaller in the five most consistent high scorers compared to the five most consistent low scorers (t= 2.77,p= 0.025). The implications for possible relationships between healthy medial temporal lobe structures and memory are discussed.

scholarly journals Neural Pattern Change During Encoding of a Narrative Predicts Retrospective Duration Estimates

2016 ◽  
Author(s):  
Olga Lositsky ◽  
Janice Chen ◽  
Daniel Toker ◽  
Christopher J Honey ◽  
Jordan L Poppenk ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Entorhinal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobes ◽  
Anterior Temporal Lobe ◽  
Temporal Lobes ◽  
Contextual Features ◽  
Pattern Change ◽  
Behavioral Studies ◽  
The Right

What mechanisms support our ability to estimate durations on the order of minutes? Behavioral studies in humans have shown that changes in contextual features lead to overestimation of past durations. Based on evidence that the medial temporal lobes and prefrontal cortex represent contextual features, we related the degree of fMRI pattern change in these regions with people's subsequent duration estimates. After listening to a radio story in the scanner, participants were asked how much time had elapsed between pairs of clips from the story. Our ROI analysis found that the neural pattern distance between two clips at encoding was correlated with duration estimates in the right entorhinal cortex and right pars orbitalis. Moreover, a whole-brain searchlight analysis revealed a cluster spanning the right anterior temporal lobe. Our findings provide convergent support for the hypothesis that retrospective time judgments are driven by 'drift' in contextual representations supported by these regions.

Visuospatial memory and learning in first-episode schizophreniform psychosis and established schizophrenia: a functional correlate of hippocampal pathology?

2002 ◽  
Vol 32 (3) ◽  
pp. 429-438 ◽  
Author(s):  
S. J. WOOD ◽  
T. PROFFITT ◽  
K. MAHONY ◽  
D. J. SMITH ◽  
J.-A. BUCHANAN ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Associative Learning ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Spatial Working Memory ◽  
Learning Ability ◽  
First Episode ◽  
Visuospatial Memory ◽  
Learning Test ◽  
The Right

Background. Despite a number of studies that have indicated impaired memory function in patients with schizophrenia, there have been few that have used a sensitive measure of right medial temporal lobe pathology. Given the reported findings of reduced hippocampal volume in schizophrenia, we used a theoretically sensitive test of the right medial temporal lobe to determine the nature of the visuospatial memory deficit in the disorder.Methods. Seventy-six patients (37 with a first-episode schizophreniform psychosis, and 39 with established schizophrenia) were compared with 41 comparison subjects on a number of tests of visuospatial memory. These included spatial working memory, spatial and pattern recognition memory and a pattern-location associative learning test.Results. Both patient groups displayed recognition memory deficits when compared to the comparison group. However, only those patients with established schizophrenia (of 9 years duration on average) were impaired on the associative learning test.Conclusions. The results indicate either a progressive decline in visuospatial associative learning ability over the course of the disorder, or that poor visuospatial associative learning is a marker for poor prognosis. In addition, these results have implications for our understanding of the role of the right medial temporal lobe in the pathophysiology of schizophrenia.

scholarly journals Thanks for the memories: Extending the hippocampal-diencephalic mnemonic system

1999 ◽  
Vol 22 (3) ◽  
pp. 471-479 ◽  
Author(s):  
John P. Aggleton ◽  
Malcolm W. Brown
Keyword(s):  
Prefrontal Cortex ◽  
Recognition Memory ◽  
Episodic Memory ◽  
Temporal Lobe ◽  
Thalamic Nuclei ◽  
Target Article ◽  
Anterior Thalamic Nuclei ◽  
Relationship Of ◽  
The Relationship ◽  
Key Questions

The goal of our target article was to review a number of emerging facts about the effects of limbic damage on memory in humans and animals, and about divisions within recognition memory in humans. We then argued that this information can be synthesized to produce a new view of the substrates of episodic memory. The key pathway in this system is from the hippocampus to the anterior thalamic nuclei. There seems to be a general agreement that the importance of this pathway has previously been underestimated and that it warrants further study. At the same time, a number of key questions remain. These concern the relationship of this system to another temporal-lobe/diencephalic system that contributes to recognition, and the relationship of these systems to prefrontal cortex activity.

scholarly journals Neural pattern change during encoding of a narrative predicts retrospective duration estimates

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Olga Lositsky ◽  
Janice Chen ◽  
Daniel Toker ◽  
Christopher J Honey ◽  
Michael Shvartsman ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Entorhinal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobes ◽  
Anterior Temporal Lobe ◽  
Temporal Lobes ◽  
Contextual Features ◽  
Pattern Change ◽  
Behavioral Studies ◽  
The Right

What mechanisms support our ability to estimate durations on the order of minutes? Behavioral studies in humans have shown that changes in contextual features lead to overestimation of past durations. Based on evidence that the medial temporal lobes and prefrontal cortex represent contextual features, we related the degree of fMRI pattern change in these regions with people’s subsequent duration estimates. After listening to a radio story in the scanner, participants were asked how much time had elapsed between pairs of clips from the story. Our ROI analyses found that duration estimates were correlated with the neural pattern distance between two clips at encoding in the right entorhinal cortex. Moreover, whole-brain searchlight analyses revealed a cluster spanning the right anterior temporal lobe. Our findings provide convergent support for the hypothesis that retrospective time judgments are driven by 'drift' in contextual representations supported by these regions.

Frontal  activation  patterns  during  Tetris game  play  and  differences  between  high  and  low performers:  a preliminary functional  near-infrared  spectroscopy study

2019 ◽  
Author(s):  
Takayuki Nakahachi ◽  
Ryouhei Ishii ◽  
Leonides Canuet ◽  
Iori Sato ◽  
Kiyoko Kamibeppu ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Infrared Spectroscopy ◽  
Frontal Cortex ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Cortical Activation ◽  
The Other ◽  
Functional Near Infrared Spectroscopy ◽  
Activation Patterns ◽  
The Right

Abstract Background: Tetris has recently expanded its place of activity not only to the original entertainment but also to clinical applications such as prevention of trauma flashback. However, to our knowledge, no studies focused on the cortical activation patterns themselves when playing Tetris in a natural form. This study aimed to investigate the activation patterns in the frontal cortex during naturally-performed Tetris for 90 seconds in 24 healthy subjects using functional near-infrared spectroscopy robust to artifacts by motion and electric devices. We also calculated the correlations of behavioral data with cortical activations, and compared the differences in activations between the high and low performers of Tetris. Results: The results demonstrated that significant activations in the frontal cortex during Tetris play had two factors, each showing a similar activation pattern. One of the factors was distributed over the lateral prefrontal cortex bilaterally, and the other was localized to the right prefrontal cortex. Moreover, in the high performers, the activations of the areas centered on the right dorsolateral prefrontal cortex (DLPFC) were estimated to increase and correlations of the activations between those areas and the other areas decrease compared with the low performers. Conclusions: It is suggested that high Tetris performers might reduce functional connectivity between activations of the areas centered on the right DLPFC and the other areas, and increase the local activations compared with low performers. It would be necessary to consider whether its visuospatial cognitive loads stimulate the appropriate areas of the subject’s brain to effectively utilize Tetris play for clinical interventions.

scholarly journals Your verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hirotaka Iwaki ◽  
Masaki Sonoda ◽  
Shin-ichiro Osawa ◽  
Brian H. Silverstein ◽  
Takumi Mitsuhashi ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Semantic Integration ◽  
Gamma Activity ◽  
Auditory Information ◽  
Inhibitory Function ◽  
Left Posterior ◽  
High Gamma ◽  
Prefrontal Region ◽  
Anterior Prefrontal Cortex ◽  
The Right

AbstractThe left prefrontal cortex is essential for verbal communication. It remains uncertain at what timing, to what extent, and what type of phrase initiates left-hemispheric dominant prefrontal activation during comprehension of spoken sentences. We clarified this issue by measuring event-related high-gamma activity during a task to respond to three-phrase questions configured in different orders. Questions beginning with a wh-interrogative deactivated the left posterior prefrontal cortex right after the 1st phrase offset and the anterior prefrontal cortex after the 2nd phrase offset. Left prefrontal high-gamma activity augmented subsequently and maximized around the 3rd phrase offset. Conversely, questions starting with a concrete phrase deactivated the right orbitofrontal region and then activated the left posterior prefrontal cortex after the 1st phrase offset. Regardless of sentence types, high-gamma activity emerged earlier, by one phrase, in the left posterior prefrontal than anterior prefrontal region. Sentences beginning with a wh-interrogative may initially deactivate the left prefrontal cortex to prioritize the bottom-up processing of upcoming auditory information. A concrete phrase may obliterate the inhibitory function of the right orbitofrontal region and facilitate top-down lexical prediction by the left prefrontal cortex. The left anterior prefrontal regions may be recruited for semantic integration of multiple concrete phrases.

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