scholarly journals Host–pathogen coevolution in human tuberculosis

2012 ◽  
Vol 367 (1590) ◽  
pp. 850-859 ◽  
Author(s):  
Sebastien Gagneux
Keyword(s):  
Epidemiological Data ◽  
Population Increase ◽  
Animal Origin ◽  
Human Populations ◽  
Common View ◽  
The World ◽  
Inflammatory Phenotype ◽  
The Common ◽  
Out Of Africa ◽  
Phylogenetic Lineages

Tuberculosis (TB) is a disease of antiquity. Yet TB today still causes more adult deaths than any other single infectious disease. Recent studies show that contrary to the common view postulating an animal origin for TB, Mycobacterium tuberculosis complex (MTBC), the causative agent of TB, emerged as a human pathogen in Africa and colonized the world accompanying the Out-of-Africa migrations of modern humans. More recently, evolutionarily ‘modern’ lineages of MTBC expanded as a consequence of the global human population increase, and spread throughout the world following waves of exploration, trade and conquest. While epidemiological data suggest that the different phylogenetic lineages of MTBC might have adapted to different human populations, overall, the phylogenetically ‘modern’ MTBC lineages are more successful in terms of their geographical spread compared with the ‘ancient’ lineages. Interestingly, the global success of ‘modern’ MTBC correlates with a hypo-inflammatory phenotype in macrophages, possibly reflecting higher virulence, and a shorter latency in humans. Finally, various human genetic variants have been associated with different MTBC lineages, suggesting an interaction between human genetic diversity and MTBC variation. In summary, the biology and the epidemiology of human TB have been shaped by the long-standing association between MTBC and its human host.

scholarly journals The Concept of Feasibility: A Multivocal Account

Res Publica ◽  
2021 ◽  
Author(s):  
Daniel Guillery
Keyword(s):  
Political Philosophy ◽  
Political Theory ◽  
Moral Theory ◽  
Common View ◽  
The World ◽  
Common Objection ◽  
The Common

AbstractA common objection to a proposal or theory in political philosophy is that it is not feasible to realise what it calls for. This is commonly taken to be sufficient to reject a proposal or theory: feasibility, on this common view, operates as a straightforward constraint on moral and political theory, whatever is not feasible is simply ruled out. This paper seeks to understand what we mean when we say that some proposal or outcome is or is not feasible. It will argue that no single binary definition can be given. Rather, there is a whole range of possible specifications of the term ‘feasible’, each of which selects a range of facts of the world to hold fixed. No single one of these possible specifications, though, is obviously privileged as giving the appropriate understanding of ‘feasibility’ tout court. The upshot of my account of feasibility, then, will be that the common view of feasibility as a straightforward constraint cannot be maintained: in order to reject a moral theory, it will not be sufficient simply to say that it is not feasible.

A Theory of Background Conditions

2018 ◽  
pp. 23-87
Author(s):  
Bradford Skow
Keyword(s):  
Alternative View ◽  
Background Condition ◽  
Common View ◽  
The World ◽  
The Common ◽  
The Difference

The common view about background conditions is that the difference between causes and background conditions is pragmatic, drawn in language not the world. This chapter defends an alternative view, on which the difference is metaphysical, drawn in the world not in language. This alternative says that something is a background condition to C’s causing E iff it is a state (rather than an event) that is a reason why C caused E. This theory is used to answer the question of what it is to manifest a disposition; briefly, something manifests a disposition to M in C if its having that disposition is a background condition to the Cing causing the Ming.

scholarly journals The unidirectional phylogeny of Homo sapiens anchors the origin of modern humans in Eurasia

Hereditas ◽  
2021 ◽  
Vol 158 (1) ◽  
Author(s):  
Úlfur Árnason
Keyword(s):  
Nuclear Dna ◽  
Maternal Inheritance ◽  
Homo Sapiens ◽  
Human Populations ◽  
Before Present ◽  
Modern Humans ◽  
Origin Of Modern Humans ◽  
The Common ◽  
Out Of Africa ◽  
Mtdna Introgression

Abstract Background The Out of Africa hypothesis, OOAH, was challenged recently in an extended mtDNA analysis, PPA (Progressive Phylogenetic Analysis), that identified the African human populations as paraphyletic, a finding that contradicted the common OOAH understanding that Hss had originated in Africa and invaded Eurasia from there. The results were consistent with the molecular Out of Eurasia hypothesis, OOEH, and Eurasian palaeontology, a subject that has been largely disregarded in the discussion of OOAH. Results In the present study the mtDNA tree, a phylogeny based on maternal inheritance, was compared to the nuclear DNA tree of the paternally transmitted Y-chromosome haplotypes, Y-DNAs. The comparison showed full phylogenetic coherence between these two separate sets of data. The results were consistent with potentially four translocations of modern humans from Eurasia into Africa, the earliest taking place ≈ 250,000 years before present, YBP. The results were in accordance with the postulates behind OOEH at the same time as they lent no support to the OOAH. Conclusions The conformity between the mtDNA and Y-DNA phylogenies of Hss is consistent with the understanding that Eurasia was the donor and not the receiver in human evolution. The evolutionary problems related to OOAH became similarly exposed by the mtDNA introgression that took place from Hss into Neanderthals ≈ 500,000 YBP, a circumstance that demonstrated the early coexistence of the two lineages in Eurasia.

scholarly journals The new millenarianism: on the end of the world and of capitalism as we know them

2018 ◽  
Vol 18 (3) ◽  
pp. 539
Author(s):  
Alessandro Pinzani
Keyword(s):  
Political Action ◽  
Way Of Life ◽  
Common View ◽  
Machine Age ◽  
Wide Range ◽  
The World ◽  
The Common ◽  
End Of The World

In recent years the destruction of the environment and the repeated crises of capitalism have been discussed by a wide range of books. More specifically, great attention has been paid to the concepts of Anthropocene and of the second machine age. The link between these two strands consists not only in the common view that we are facing massive changes to our way of life for ecological and for economic reasons, but also in the idea that these two phenomena are interconnected. Accordingly, the destruction of the environment is a consequence of capitalism, and, at the same time, capitalism is nearing its material, natural limits. In this paper I shall briefly evaluate these diagnoses and some of the proposed remedies. Furthermore, I shall point out some philosophically relevant consequences of said debate, particularly concerning the concepts of freedom and political action. ***  O novo milenarismo Sobre o fim do mundo e do capitalismo como os conhecemos ***Nos últimos anos, a destruição do meio ambiente e as repetidas crises do capitalismo foram discutidas por uma ampla gama de livros. Mais especificamente, grande atenção tem sido dada aos conceitos de antropoceno e de segunda era da máquina. A ligação entre essas duas vertentes consiste não apenas na visão comum de que estamos enfrentando mudanças massivas em nosso modo de vida por razões ecológicas e econômicas, mas também na ideia de que esses dois fenômenos estão interconectados. Portanto, a destruição do meio ambiente é uma consequência do capitalismo e, ao mesmo tempo, o capitalismo está se aproximando de seus limites materiais e naturais. Neste artigo, vou avaliar brevemente esses diagnósticos e alguns dos remédios propostos. Além disso, apontarei algumas consequências filosoficamente relevantes do referido debate, particularmente em relação aos conceitos de liberdade e ação política.Palavras-chave: Destruição ambiental; Antropoceno; Capitalismo; Fim do trabalho; Segunda idade da máquina.

scholarly journals Using hominin introgression to trace modern human dispersals

2019 ◽  
Vol 116 (31) ◽  
pp. 15327-15332 ◽  
Author(s):  
João C. Teixeira ◽  
Alan Cooper
Keyword(s):  
New Guinea ◽  
Modern Human ◽  
Genetic Evidence ◽  
Human Populations ◽  
Before Present ◽  
Archaeological Evidence ◽  
Fossil Evidence ◽  
The World ◽  
Out Of Africa ◽  
Wallace’S Line

The dispersal of anatomically modern human populations out of Africa and across much of the rest of the world around 55 to 50 thousand years before present (ka) is recorded genetically by the multiple hominin groups they met and interbred with along the way, including the Neandertals and Denisovans. The signatures of these introgression events remain preserved in the genomes of modern-day populations, and provide a powerful record of the sequence and timing of these early migrations, with Asia proving a particularly complex area. At least 3 different hominin groups appear to have been involved in Asia, of which only the Denisovans are currently known. Several interbreeding events are inferred to have taken place east of Wallace’s Line, consistent with archaeological evidence of widespread and early hominin presence in the area. However, archaeological and fossil evidence indicates archaic hominins had not spread as far as the Sahul continent (New Guinea, Australia, and Tasmania), where recent genetic evidence remains enigmatic.

scholarly journals Phylogenetic population structure and drug resistance of Mycobacterium tuberculosis complex in the Volta Region of Ghana

2020 ◽  
Author(s):  
Selassie Ameke ◽  
Prince Asare ◽  
Sammy Yaw Aboagye ◽  
Isaac Darko Otchere ◽  
Stephen Osei-Wusu ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Population Structure ◽  
Epidemiological Data ◽  
Drug Susceptibility ◽  
Sensu Stricto ◽  
P Value ◽  
Human Populations ◽  
Volta Region ◽  
Heat Shock Protein 65 ◽  
Phylogenetic Lineages

AbstractContextAvailable molecular epidemiological data from recent studies suggest significant genetic variation between the different phylogenetic lineages of Mycobacterium tuberculosis complex (MTBC) and the MTBC lineages might have adapted to different human populationsAimThis study sought to determine the phylogenetic population structure of clinical MTBC isolates from the Volta Region of Ghana.MethodsThe MTBC isolates obtained from collected sputum samples were characterized by standard methods. Non-tuberculous mycobacterial isolates were characterized by amplification of the heat shock protein 65 (hsp65) gene and sequencing. The drug susceptibility profiles of the MTBCs determined using GenoType MTBDRplusResultsOne hundred and seventeen (117, 93.6%) out of 125 mycobacterial positive isolates were characterized as members of the MTBC of which M. tuberculosis sensu stricto (MTBss) and M. africanum (Maf) were respectively 94 (80.3%) and 23 (19.7%). In all, 39 distinct spoligotype patterns were obtained; 26 for MTBss and 13 for Maf lineages. Spoligotyping identified 89 (76.04 %) Lineage 4, 16 (13.7 %) Lineage 5, 7 (6.0%) Lineage 6, 3 (2.6%) Lineage 2, 1(0.9%) Lineage 3 and 1 (0.9%) Lineage 1. Among the Lineage 4 isolates, 62/89 (69.7%) belonged to Cameroon sub-lineage, 13 (14.6%) Ghana, 8 (9.0%) Haarlem, 2 (2.2%) LAM, 1 (1.1%) Uganda I, 1 (1.1%) X and the remaining two were orphan. Significant localization of Maf was found within the Ho municipality (n=13, 29.5%) compared to the more cosmopolitan Ketu-South/Aflao (n=3, 8.3%) (p-value= 0.017). Eight (8) non-tuberculous mycobacteria were characterized as M. abscessus (7) and M. fortuitum (1)ConclusionWe confirmed the importance of M. africanum lineages as a cause of TB in the Volta region of Ghana.Key MessageThe phylogenetic population structure obtained agrees with previously described prevalence of M. tuberculosis complex phylogenetic lineages from other regions of Ghana. It also confirms the stable prevalence of M. africanum as an important human TB causing pathogen in Ghana.

Articulatory Generalization in Two Word-Medial, Ambisyllabic Contexts

1988 ◽  
Vol 19 (3) ◽  
pp. 251-258 ◽  
Author(s):  
Virginia I. Wolfe ◽  
Suzanne D. Blocker ◽  
Norma J. Prater
Keyword(s):  
Common View ◽  
Perceptual Salience ◽  
The Common ◽  
Unitary Concept ◽  
Over Time

Articulatory generalization of velar cognates /k/, /g/ in two phonologically disordered children was studied over time as a function of sequential word-morpheme position training. Although patterns of contextual acquisition differed, correct responses to the word-medial, inflected context (e.g., "picking," "hugging") occurred earlier and exceeded those to the word-medial, noninflected context (e.g., "bacon," "wagon"). This finding indicates that the common view of the word-medial position as a unitary concept is an oversimplification. Possible explanations for superior generalization to the word-medial, inflected position are discussed in terms of coarticulation, perceptual salience, and the representational integrity of the word.

Between High Culture and Low Culture; and also The Difference Between Popular Culture and Folk Culture

2019 ◽  
Vol 7 (8) ◽  
pp. 12
Author(s):  
Kunal Debnath
Keyword(s):  
Popular Culture ◽  
Folk Culture ◽  
Common People ◽  
High Culture ◽  
The World ◽  
The Common ◽  
The Difference ◽  
Low Culture

High culture is a collection of ideologies, beliefs, thoughts, trends, practices and works-- intellectual or creative-- that is intended for refined, cultured and educated elite people. Low culture is the culture of the common people and the mass. Popular culture is something that is always, most importantly, related to everyday average people and their experiences of the world; it is urban, changing and consumeristic in nature. Folk culture is the culture of preindustrial (premarket, precommodity) communities.

Current issues in aesthetics and beyond: Revisiting lookism

2020 ◽  
Vol 10 (1-2) ◽  
pp. 59-68
Author(s):  
Peter Takáč
Keyword(s):  
Plastic Surgery ◽  
Social Impact ◽  
Human Beings ◽  
Common View ◽  
Aesthetic Medicine ◽  
Unequal Treatment ◽  
Self Confidence ◽  
Public Status ◽  
The Social ◽  
The Common

AbstractLookism is a term used to describe discrimination based on the physical appearance of a person. We suppose that the social impact of lookism is a philosophical issue, because, from this perspective, attractive people have an advantage over others. The first line of our argumentation involves the issue of lookism as a global ethical and aesthetical phenomenon. A person’s attractiveness has a significant impact on the social and public status of this individual. The common view in society is that it is good to be more attractive and healthier. This concept generates several ethical questions about human aesthetical identity, health, authenticity, and integrity in society. It seems that this unequal treatment causes discrimination, diminishes self-confidence, and lowers the chance of a job or social enforcement for many human beings. Currently, aesthetic improvements are being made through plastic surgery. There is no place on the human body that we cannot improve with plastic surgery or aesthetic medicine. We should not forget that it may result in the problem of elitism, in dividing people into primary and secondary categories. The second line of our argumentation involves a particular case of lookism: Melanie Gaydos. A woman that is considered to be a model with a unique look.

Current updates on COVID-19 - A review

2020 ◽  
Vol 10 (1) ◽  
pp. 1-8
Author(s):  
Ghotekar D S ◽  
Vishal N Kushare ◽  
Sagar V Ghotekar
Keyword(s):  
World Health Organization ◽  
Common Cold ◽  
Respiratory Diseases ◽  
Gastrointestinal Diseases ◽  
Hubei Province ◽  
World Health ◽  
The World ◽  
The Common ◽  
Novel Coronavirus ◽  
Health Organization

Coronaviruses are a family of viruses that cause illness such as respiratory diseases or gastrointestinal diseases. Respiratory diseases can range from the common cold to more severe diseases. A novel coronavirus outbreak was first documented in Wuhan, Hubei Province, China in December 2019. The World Health Organization (WHO) has declared the coronavirus disease 2019 (COVID-19) a pandemic. A global coordinated effort is needed to stop the further spread of the virus. A novel coronavirus (nCoV) is a new strain that has not been identified in humans previously. Once scientists determine exactly what coronavirus it is, they give it a name (as in the case of COVID-19, the virus causing it is SARS-CoV-2).

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