scholarly journals Variola virus genome sequenced from an eighteenth-century museum specimen supports the recent origin of smallpox

2020 ◽  
Vol 375 (1812) ◽  
pp. 20190572 ◽  
Author(s):  
Giada Ferrari ◽  
Judith Neukamm ◽  
Helle T. Baalsrud ◽  
Abagail M. Breidenstein ◽  
Mark Ravinet ◽  
...  

Smallpox, caused by the variola virus (VARV), was a highly virulent disease with high mortality rates causing a major threat for global human health until its successful eradication in 1980. Despite previously published historic and modern VARV genomes, its past dissemination and diversity remain debated. To understand the evolutionary history of VARV with respect to historic and modern VARV genetic variation in Europe, we sequenced a VARV genome from a well-described eighteenth-century case from England (specimen P328). In our phylogenetic analysis, the new genome falls between the modern strains and another historic strain from Lithuania, supporting previous claims of larger diversity in early modern Europe compared to the twentieth century. Our analyses also resolve a previous controversy regarding the common ancestor between modern and historic strains by confirming a later date around the seventeenth century. Overall, our results point to the benefit of historic genomes for better resolution of past VARV diversity and highlight the value of such historic genomes from around the world to further understand the evolutionary history of smallpox as well as related diseases. This article is part of the theme issue ‘Insights into health and disease from ancient biomolecules’.

Mammalia ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mourad Ahmim ◽  
Hafid Aroudj ◽  
Farouk Aroudj ◽  
Saaid Saidi ◽  
Samir Aroudj

Abstract The common genet (Genetta genetta Linnaeus, 1758) is a rare and protected mammal species in Algeria. We report the first melanistic individual of this species ever recorded in North Africa. Such animals have only been recorded in Spain and Portugal so far. It is unclear why melanistic common genets seem to be so rare in its African range. More research is needed to determine the true occurrence of melanistic individuals, and what the evolutionary history of melanism is in common genets.


Heredity ◽  
2002 ◽  
Vol 88 (4) ◽  
pp. 235-242 ◽  
Author(s):  
M Ratkiewicz ◽  
S Fedyk ◽  
A Banaszek ◽  
L Gielly ◽  
W Chȩtnicki ◽  
...  

Author(s):  
John Baker

This chapter explores some lines of development in contract law after 1600. First there were questions flowing from the decision in Slade’s Case – the pleading formulae known as the ‘common counts’ in indebitatus assumpsit were quickly settled and the perjury problems after the disuse of wager of law were dealt with in the Statute of Frauds 1677. Attempts to rationalize consideration in the eighteenth century were unsuccessful save that it became distinct from the requirement of an intention to be bound. The chapter traces the history of privity of contract and of the various attempts to give remedies to third-party beneficiaries. It then discusses the implication of terms into contracts, the difference between conditions and warranties, exclusion clauses, and the problems occasioned by standard-form contracts.


2019 ◽  
Vol 28 (6) ◽  
pp. 587-592 ◽  
Author(s):  
Cory J. Clark ◽  
Brittany S. Liu ◽  
Bo M. Winegard ◽  
Peter H. Ditto

Humans evolved in the context of intense intergroup competition, and groups comprised of loyal members more often succeeded than groups comprised of nonloyal members. Therefore, selective pressures have sculpted human minds to be tribal, and group loyalty and concomitant cognitive biases likely exist in all groups. Modern politics is one of the most salient forms of modern coalitional conflict and elicits substantial cognitive biases. The common evolutionary history of liberals and conservatives gives little reason to expect protribe biases to be higher on one side of the political spectrum than the other. This evolutionarily plausible null hypothesis has been supported by recent research. In a recent meta-analysis, liberals and conservatives showed similar levels of partisan bias, and several protribe cognitive tendencies often ascribed to conservatives (e.g., intolerance toward dissimilar other people) were found in similar degrees in liberals. We conclude that tribal bias is a natural and nearly ineradicable feature of human cognition and that no group—not even one’s own—is immune.


2012 ◽  
Vol 279 (1736) ◽  
pp. 2246-2254 ◽  
Author(s):  
Fabien Burki ◽  
Noriko Okamoto ◽  
Jean-François Pombert ◽  
Patrick J. Keeling

An important missing piece in the puzzle of how plastids spread across the eukaryotic tree of life is a robust evolutionary framework for the host lineages. Four assemblages are known to harbour plastids derived from red algae and, according to the controversial chromalveolate hypothesis, these all share a common ancestry. Phylogenomic analyses have consistently shown that stramenopiles and alveolates are closely related, but haptophytes and cryptophytes remain contentious; they have been proposed to branch together with several heterotrophic groups in the newly erected Hacrobia. Here, we tested this question by producing a large expressed sequence tag dataset for the katablepharid Roombia truncata , one of the last hacrobian lineages for which genome-level data are unavailable, and combined this dataset with the recently completed genome of the cryptophyte Guillardia theta to build an alignment composed of 258 genes. Our analyses strongly support haptophytes as sister to the SAR group, possibly together with telonemids and centrohelids. We also confirmed the common origin of katablepharids and cryptophytes, but these lineages were not related to other hacrobians; instead, they branch with plants. Our study resolves the evolutionary position of haptophytes, an ecologically critical component of the oceans, and proposes a new hypothesis for the origin of cryptophytes.


1946 ◽  
Vol 8 (3) ◽  
pp. 283-306 ◽  
Author(s):  
John J. Meng

The latter half of the eighteenth century was a period of tremendous social, political, and economic fermentation. Much of our contemporary civilization was shaped by the forces released during those five decades. Frenchmen, Englishmen, and Germans of great ability and deserved renown had written and were writing of the rights of man and of the citizen. More than ever before in the history of the modern world thought was being given to the lot of the common people. In America, and later in France, Thomas Paine epitomized this liberal intellectual trend in words that have been adopted as classic expressions of the inherent value of the human personality.Unfortunately, the phenomenal growth of industrial capitalism during he nineteenth and twentieth centuries caused the new bourgeois ruling classes to lose sight of the basic human values stressed so emphatically by the eighteenth-century intellectuals.


Genetics ◽  
2001 ◽  
Vol 158 (1) ◽  
pp. 401-412 ◽  
Author(s):  
Peter Tiffin ◽  
Brandon S Gaut

Abstract Polyploidy has been an extremely common phenomenon in the evolutionary history of angiosperms. Despite this there are few data available to evaluate the effects of polyploidy on genetic diversity and to compare the relative effects of drift and selection in polyploids and related diploids. We investigated DNA sequence diversity at four nuclear loci (adh1, glb1, c1, and waxy) from the tetraploid Zea perennis and the closely related diploid Z. diploperennis. Contrary to expectations, we detected no strong evidence for greater genetic diversity in the tetraploid, or for consistent differences in the effects of either drift or selection between the tetraploid and the diploid. Our failure to find greater genetic diversity in Z. perennis may result from its relatively recent origin or demographic factors associated with its origin. In addition to comparing genetic diversity in the two species, we constructed genealogies to infer the evolutionary origin of Z. perennis. Although these genealogies are equivocal regarding the mode of origin, several aspects of these genealogies support an autotetraploid origin. Consistent with previous molecular data the genealogies do not, however, support the division of Zea into two sections, the section Zea and the section Luxuriantes.


Author(s):  
Александр Каменский

The history of suicide in Russia, especially prior to the nineteenth century, remains understudied. While in most European countries the process of decriminalization and secularization of suicide was underway, in Russia, with the introduction of the Military Article of 1715, it was formally criminalized. On the basis of the study of more than 350 newly examined archival cases, this article examines how the transfer of suicide investigations to secular authorities also entailed secularization, while the peculiarities of the Russian judicial and investigative system, as well as lacunae in the legislation, actually led to the gradual decriminalization of suicide. At the same time, although among Russians, as well as among other peoples, a number of superstitions were associated with suicide, there is no evidence in the archival documents studied in this article of a particularly emotional perception of suicide. The phenomenon of suicide in eighteenth-century Russia, when compared to early modern Europe, did not have any significant, fundamental differences. However, the features of the Russian judicial-investigative system made this phenomenon less public, less visible and less significant for public consciousness.  


This edition of all of Catharine Macaulay’s known correspondence includes an introduction to the life, works, and influence of this celebrated, eighteenth-century, republican historian. Through her letters and those of her correspondents it offers a unique glimpse of the connections between radical republicanism and dissent in London, and throws light on the origins of parliamentary reform in Great Britain. Macaulay’s correspondents include many individuals who were active in the lead-up to the American and French Revolutions, others who became involved in the antislavery movement, and yet others who were central to the development of feminism. These letters demonstrate how Macaulay’s history of the seventeenth-century republican period in Great Britain, which she published between 1763 and 1783, encouraged her readers to represent themselves as the heirs of those earlier struggles and to lavish praise on the author as an important defender of their liberties and of the universal rights of mankind. It shows Macaulay and her friends to have been inspired by positive notions of liberty and by ideals of democratic republicanism, thought of as systems of equal government committed to universal benevolence, in which the common good would become the common care.


Sign in / Sign up

Export Citation Format

Share Document