scholarly journals Antifungal susceptibility profiles of Candida isolates from a prospective survey of invasive fungal infections in Italian intensive care units

2012 ◽  
Vol 61 (3) ◽  
pp. 389-393 ◽  
Author(s):  
Anna Maria Tortorano ◽  
Anna Prigitano ◽  
Giovanna Dho ◽  
Anna Grancini ◽  
Marco Passera ◽  
...  
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Fungal Infections ◽  
Antifungal Susceptibility ◽  
Invasive Fungal Infections ◽  
Prospective Survey ◽  
Susceptibility Profiles

Identification and in Vitro Susceptibility Pattern of Fungal Pathogens in Immunocompromised Patients with invasive Fungal Infections

2021 ◽  
Vol 30 (3) ◽  
pp. 127-134
Author(s):  
Shaimaa A.S. Selem ◽  
Neveen A. Hassan ◽  
Mohamed Z. Abd El-Rahman ◽  
Doaa M. Abd El-Kareem
Keyword(s):  
Intensive Care ◽  
Fungal Infection ◽  
Fungal Pathogens ◽  
Fungal Infections ◽  
Antifungal Susceptibility ◽  
Invasive Fungal Infections ◽  
Immunocompromised Patients ◽  
University Hospitals ◽  
Vitek 2

Background: In intensive care units, invasive fungal infections have become more common, particularly among immunocompromised patients. Early identification and starting the treatment of those patients with antifungal therapy is critical for preventing unnecessary use of toxic antifungal agents. Objective: The aim of this research is to determine which common fungi cause invasive fungal infection in immunocompromised patients, as well as their antifungal susceptibility patterns in vitro, in Assiut University Hospitals. Methodology: This was a hospital based descriptive study conducted on 120 patients with clinical suspicion of having fungal infections admitted at different Intensive Care Units (ICUs) at Assiut University Hospitals. Direct microscopic examination and inoculation on Sabouraud Dextrose Agar (SDA) were performed on the collected specimens. Isolated yeasts were classified using phenotypic methods such as chromogenic media (Brilliance Candida agar), germ tube examination, and the Vitek 2 system for certain isolates, while the identification of mould isolates was primarily based on macroscopic and microscopic characteristics. Moulds were tested in vitro for antifungal susceptibility using the disc diffusion, and yeast were tested using Vitek 2 device cards. Results: In this study, 100 out of 120 (83.3%) of the samples were positive for fungal infection. Candida and Aspergillus species were the most commonly isolated fungal pathogens. The isolates had the highest sensitivity to Amphotericin B (95 %), followed by Micafungin (94 %) in an in vitro sensitivity survey. Conclusion: Invasive fungal infections are a leading cause of morbidity and mortality in immunocompromised patients, with Candida albicans being the most frequently isolated yeast from various clinical specimens; however, the rise in resistance, especially to azoles, is a major concern.

Biofilm production byCandidaisolates from a survey of invasive fungal infections in Italian intensive care units

2012 ◽  
Vol 24 (1) ◽  
pp. 61-63 ◽  
Author(s):  
Anna Prigitano ◽  
Giovanna Dho ◽  
Cristina Lazzarini ◽  
Cristina Ossi ◽  
Caterina Cavanna ◽  
...  
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Fungal Infections ◽  
Invasive Fungal Infections ◽  
Biofilm Production

Treatment of invasive fungal infections in intensive care units with micafungin: The MYRIADE study

Mycoses ◽  
2020 ◽  
Vol 63 (5) ◽  
pp. 443-451 ◽  
Author(s):  
Jean‐François Timsit ◽  
Guy Leverger ◽  
Noël Milpied ◽  
Bertrand Gachot
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Fungal Infections ◽  
Invasive Fungal Infections

scholarly journals Prevalence and impact of invasive fungal infections in intensive care

Critical Care ◽  
2013 ◽  
Vol 17 (S2) ◽  
Author(s):  
JM Patel ◽  
K Couper ◽  
T Melody ◽  
R O'Brien ◽  
D Parekh
Keyword(s):  
Intensive Care ◽  
Fungal Infections ◽  
Invasive Fungal Infections

Invasive fungal infections in the intensive care unit: a multicentre, prospective, observational study in Italy (2006-2008)

Mycoses ◽  
2011 ◽  
Vol 55 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Anna Maria Tortorano ◽  
Giovanna Dho ◽  
Anna Prigitano ◽  
Giuseppe Breda ◽  
Anna Grancini ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Fungal Infections ◽  
Invasive Fungal Infections

GRYBELINĖS INFEKCIJOS INTENSYVIOSIOS TERAPIJOS SKYRIUJE

2021 ◽  
Vol 31 (1) ◽  
pp. 15-18
Author(s):  
Martynas Zaremba ◽  
Vykinta Zeleckytė ◽  
Valdonė Ališkevičiūtė
Keyword(s):  
Candida Albicans ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Fungal Infections

Grybelinės infekcijos vis dažniau diagnozuojamos intensyviosios terapijos skyriuose ir tampa viena iš dažniausių sunkios būklės pacientų mirties priežasčių. Manoma, jog grybelinės infekcijos riziką didina netinkamai taikoma antibiotikoterapija, didelis imunosupresinių pacientų kiekis ir jiems atliekamos sudėtingos intervencinės procedūros. Didžioji dalis grybelinių infekcijų yra sukelta Candida genties grybelių, dažniausiai – Candida albicans. EPIC II 2007 metais atliktame tyrime 1265 pacientams iš 75 šalių buvo rasta, jog 19 proc. patogenų intensyviosios terapijos skyriuose sudarė grybeliai. Dažniausia gentis – Candida bei Aspergillus. Darbo tikslas – apžvelgti dažniausiai pasitaikančias grybelines infekcijas intensyviosios terapijos skyriuose, jų diagnostiką bei gydymą, atsižvelgiant į publikuotus mokslinius šaltinius. Literatūros šaltinių paieška buvo vykdoma tarptautinėse medicinos duomenų bazėse PubMed, UpToDate, Medscape. Į sisteminę apžvalgą įtraukti anglų kalba 2010–2020 m. publikuoti atsitiktinių imčių kontroliuojami tyrimai, originalūs stebėjimo tyrimai, atvejų ataskaitos, atvejų serijos ir apžvalgos pagal raktinius žodžius ir jų derinius: fungal infections, fungal infections in the intensive care units (ICU), fungal infections diagnostics and treatment. Mokslinių leidinių analizės rezultatai parodė grybelinės infekcijos intensyviosios terapijos skyriuose dažnėjimą, nes dėl radikalaus gydymo bei invazinių procedūrų daugėja imunosupresiškų pacientų. Dažniausia grybelinės infekcijos diagnostikos priemonė yra pasėlis. Grybelinės infekcijos gydymas priklauso nuo specifinio sukėlėjo. Dažniausiai vartojamos vaistų grupės yra azolai bei polienai.

scholarly journals Overview on the Prevalence of Fungal Infections, Immune Response, and Microbiome Role in COVID-19 Patients

2021 ◽  
Vol 7 (9) ◽  
pp. 720
Author(s):  
Maryam Roudbary ◽  
Sunil Kumar ◽  
Awanish Kumar ◽  
Lucia Černáková ◽  
Fatemeh Nikoomanesh ◽  
...  
Keyword(s):  
Immune Response ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Fungal Infections ◽  
Fungal Species ◽  
Fungal Diseases ◽  
Severe Illness ◽  
Rising Incidence ◽  
Cryptococcus Spp

Patients with severe COVID-19, such as individuals in intensive care units (ICU), are exceptionally susceptible to bacterial and fungal infections. The most prevalent fungal infections are aspergillosis and candidemia. Nonetheless, other fungal species (for instance, Histoplasma spp., Rhizopus spp., Mucor spp., Cryptococcus spp.) have recently been increasingly linked to opportunistic fungal diseases in COVID-19 patients. These fungal co-infections are described with rising incidence, severe illness, and death that is associated with host immune response. Awareness of the high risks of the occurrence of fungal co-infections is crucial to downgrade any arrear in diagnosis and treatment to support the prevention of severe illness and death directly related to these infections. This review analyses the fungal infections, treatments, outcome, and immune response, considering the possible role of the microbiome in these patients. The search was performed in Medline (PubMed), using the words “fungal infections COVID-19”, between 2020–2021.

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