scholarly journals Effect of the supplementation of Coconopsis lanceolata extract on lipid metabolism amelioration in type 2 diabetes mouse model induced by high fat diet

2014 ◽  
Vol 21 (1) ◽  
pp. 107-113 ◽  
Author(s):  
Won-Kap Yun ◽  
Hyun-Ji Bae ◽  
You-Jeong Kim ◽  
O Jun Kwon ◽  
Moo Hyeog Im ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Metabolism ◽  
Mouse Model ◽  
High Fat Diet ◽  
High Fat ◽  
Diabetes Mouse

A new mouse model of type 2 diabetes mellitus established through combination of high-fat-diet, streptozotocin and glucocorticoid

Life Sciences ◽  
2021 ◽  
pp. 120062
Author(s):  
Sha Liu ◽  
Lingling Ma ◽  
Xiaoyu Ren ◽  
Wenling Zhang ◽  
Dian Shi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Model ◽  
High Fat Diet ◽  
High Fat

Lactobacillus acidophilus alleviates type 2 diabetes by regulating hepatic glucose, lipid metabolism and gut microbiota in mice

2019 ◽  
Vol 10 (9) ◽  
pp. 5804-5815 ◽  
Author(s):  
Fenfen Yan ◽  
Na Li ◽  
Jialu Shi ◽  
Huizhen Li ◽  
Yingxue Yue ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Metabolism ◽  
Gut Microbiota ◽  
Lactobacillus Acidophilus ◽  
High Fat Diet ◽  
High Fat ◽  
Glucose And Lipid Metabolism ◽  
Hepatic Glucose

Lactobacillus acidophilus alleviates type 2 diabetes induced by a high fat diet and streptozotocin (STZ) injection by regulating gut microbiota, hepatic glucose and lipid metabolism in mice.

scholarly journals Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes

2021 ◽  
Vol 12 ◽  
Author(s):  
Laila Silamiķele ◽  
Ivars Silamiķelis ◽  
Monta Ustinova ◽  
Zane Kalniņa ◽  
Ilze Elbere ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gut Microbiome ◽  
High Fat Diet ◽  
Abundant Species ◽  
Metformin Treatment ◽  
High Fat ◽  
Microbiome Composition ◽  
Before And After ◽  
Diabetes Mouse

Effects of metformin, the first-line drug for type 2 diabetes therapy, on gut microbiome composition in type 2 diabetes have been described in various studies both in human subjects and animals. However, the details of the molecular mechanisms of metformin action have not been fully understood. Moreover, there is a significant lack of information on how metformin affects gut microbiome composition in female mouse models, depending on sex and metabolic status in well controlled experimental setting. Our study aimed to examine metformin-induced alterations in gut microbiome diversity, composition, and functional implications of high-fat diet-induced type 2 diabetes mouse model, using, for the first time in mice study, the shotgun metagenomic sequencing that allows estimation of microorganisms at species level. We also employed a randomized block, factorial study design, and including 24 experimental units allocated to 8 treatment groups to systematically evaluate the effect of sex and metabolic status on metformin interaction with microbiome. We used DNA obtained from fecal samples representing gut microbiome before and after ten weeks-long metformin treatment. We identified 100 metformin-related differentially abundant species in high-fat diet-fed mice before and after the treatment, with most of the species relative abundances increased. In contrast, no significant changes were observed in control diet-fed mice. Functional analysis targeted to carbohydrate, lipid, and amino acid metabolism pathways revealed 14 significantly altered hierarchies. We also observed sex-specific differences in response to metformin treatment. Males experienced more pronounced changes in metabolic markers, while in females the extent of changes in gut microbiome representatives was more marked, indicated by 53 differentially abundant species with more remarkable Log fold changes compared to the combined-sex analysis. The same pattern manifested regarding the functional analysis, where we discovered 5 significantly affected hierarchies in female groups but not in males. Our results suggest that both sexes of animals should be included in future studies focusing on metformin effects on the gut microbiome.

scholarly journals Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet

Diabetologia ◽  
2009 ◽  
Vol 52 (4) ◽  
pp. 675-683 ◽  
Author(s):  
T. Kusakabe ◽  
H. Tanioka ◽  
K. Ebihara ◽  
M. Hirata ◽  
L. Miyamoto ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Model ◽  
High Fat Diet ◽  
High Fat ◽  
Beneficial Effects ◽  
Lipid Control

scholarly journals Metformin strongly affects gut microbiome composition in high-fat diet-induced type 2 diabetes mouse model of both sexes

2020 ◽  
Author(s):  
Laila Silamiķele ◽  
Ivars Silamiķelis ◽  
Monta Ustinova ◽  
Zane Kalniņa ◽  
Ilze Elbere ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gut Microbiome ◽  
High Fat Diet ◽  
Abundant Species ◽  
Metformin Treatment ◽  
High Fat ◽  
Microbiome Composition ◽  
Before And After ◽  
Diabetes Mouse

AbstractEffects of metformin, the first-line drug for type 2 diabetes therapy, on gut microbiome composition in type 2 diabetes have been described in various studies both in human subjects and animals. However, the details of the molecular mechanisms of metformin action have not been fully understood. Moreover, there is a significant lack of information on how metformin affects gut microbiome composition in female mice models, as most of the existing studies have focused on males only.Our study aimed to examine metformin-induced alterations in gut microbiome diversity and composition of high-fat diet-induced type 2 diabetes mouse model, employing a randomized block, factorial study design, and including 24 experimental units allocated to 8 treatment groups. We performed shotgun metagenomic sequencing using DNA obtained from fecal samples representing gut microbiome before and after ten weeks-long metformin treatment.We identified 100 metformin-related differentially abundant species in high-fat diet-fed mice before and after the treatment, with most of the species abundances increased. In contrast, no significant changes were observed in control diet-fed mice.We also observed sex-specific differences in response to metformin treatment. Males experienced more pronounced changes in metabolic markers, while, in females, the extent of changes in gut microbiome representatives was more marked, indicated by 53 differentially abundant species with more remarkable Log fold changes compared to the combined-sex analysis. Our results suggest that both sexes of animals should be included in future studies focusing on metformin effects on the gut microbiome.

scholarly journals Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0195411 ◽  
Author(s):  
Lijie Liu ◽  
Yi Huang ◽  
Cong Fang ◽  
Hongyu Zhang ◽  
Jing Yang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Mouse Model ◽  
High Fat Diet ◽  
Noise Exposure ◽  
High Fat
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