scholarly journals Hippocampal and Parahippocampal Grey Matter Structural Integrity Assessed by Multimodal Imaging is Associated With Episodic Memory in Old Age

2020 ◽  
Author(s):  
Ylva Köhncke ◽  
Sandra Düzel ◽  
Myriam C. Sander ◽  
Ulman Lindenberger ◽  
Simone Kühn ◽  
...  
Keyword(s):  
Individual Differences ◽  
Episodic Memory ◽  
Old Age ◽  
Grey Matter ◽  
Structural Integrity ◽  
Mean Diffusivity ◽  
Human Memory ◽  
Parahippocampal Gyrus ◽  
Magnetization Transfer Ratio ◽  
Measurement Models

AbstractMaintained structural integrity of hippocampal and cortical grey matter may explain why some older adults show rather preserved episodic memory. However, viable measurement models for estimating individual differences in grey matter structural integrity are lacking; instead, findings rely on fallible single indicators of integrity. Here, we introduce multitrait-multimethod (MTMM) methodology to capture individual differences in grey matter integrity, based on multimodal structural imaging in a large sample of 1,522 healthy adults aged 60 to 88 years from the Berlin Aging Study II, including 331 participants who underwent MR imaging. Structural integrity factors expressed the common variance of voxel-based morphometry (VBM), mean diffusivity (MD), and magnetization transfer ratio (MT) for each of four regions of interest (ROI): hippocampus, parahippocampal gyrus, prefrontal cortex, and precuneus. Except for precuneus, the integrity factors correlated with episodic memory. Associations with hippocampal and parahippocampal integrity persisted after controlling for age, sex, and education. Our results support the proposition that episodic memory ability in old age benefits from maintained structural integrity of hippocampus and parahippocampal gyrus. Exploratory follow-up analyses on sex differences showed that this effect is restricted to men. Multimodal factors of structural brain integrity might help improve our biological understanding of human memory aging.

scholarly journals Hippocampal and Parahippocampal Gray Matter Structural Integrity Assessed by Multimodal Imaging Is Associated with Episodic Memory in Old Age

2020 ◽  
Author(s):  
Ylva Köhncke ◽  
Sandra Düzel ◽  
Myriam C Sander ◽  
Ulman Lindenberger ◽  
Simone Kühn ◽  
...  
Keyword(s):  
Individual Differences ◽  
Episodic Memory ◽  
Old Age ◽  
Gray Matter ◽  
Structural Integrity ◽  
Mean Diffusivity ◽  
Human Memory ◽  
Parahippocampal Gyrus ◽  
Magnetization Transfer Ratio ◽  
Measurement Models

Abstract Maintained structural integrity of hippocampal and cortical gray matter may explain why some older adults show rather preserved episodic memory. However, viable measurement models for estimating individual differences in gray matter structural integrity are lacking; instead, findings rely on fallible single indicators of integrity. Here, we introduce multitrait–multimethod methodology to capture individual differences in gray matter integrity, based on multimodal structural imaging in a large sample of 1522 healthy adults aged 60–88 years from the Berlin Aging Study II, including 333 participants who underwent magnetic resonance imaging. Structural integrity factors expressed the common variance of voxel-based morphometry, mean diffusivity, and magnetization transfer ratio for each of four regions of interest: hippocampus, parahippocampal gyrus, prefrontal cortex, and precuneus. Except for precuneus, the integrity factors correlated with episodic memory. Associations with hippocampal and parahippocampal integrity persisted after controlling for age, sex, and education. Our results support the proposition that episodic memory ability in old age benefits from maintained structural integrity of hippocampus and parahippocampal gyrus. Exploratory follow-up analyses on sex differences showed that this effect is restricted to men. Multimodal factors of structural brain integrity might help to improve our biological understanding of human memory aging.

Individual differences in white and grey matter structure associated with verbal habits of thought

2019 ◽  
Author(s):  
Justin C. Hayes ◽  
Katherine L Alfred ◽  
Rachel Pizzie ◽  
Joshua S. Cetron ◽  
David J. M. Kraemer
Keyword(s):  
Individual Differences ◽  
White Matter ◽  
Cognitive Processing ◽  
Grey Matter ◽  
Structural Changes ◽  
Structural Integrity ◽  
Diffusion Tensor ◽  
Self Report ◽  
White Matter Tracts

Modality specific encoding habits account for a significant portion of individual differences reflected in functional activation during cognitive processing. Yet, little is known about how these habits of thought influence long-term structural changes in the brain. Traditionally, habits of thought have been assessed using self-report questionnaires such as the visualizer-verbalizer questionnaire. Here, rather than relying on subjective reports, we measured habits of thought using a novel behavioral task assessing attentional biases toward picture and word stimuli. Hypothesizing that verbal habits of thought are reflected in the structural integrity of white matter tracts and cortical regions of interest, we used diffusion tensor imaging and volumetric analyses to assess this prediction. Using a whole-brain approach, we show that word bias is associated with increased volume in several bilateral language regions, in both white and grey matter parcels. Additionally, connectivity within white matter tracts within an a priori speech production network increased as a function of word bias. These results demonstrate long-term structural and morphological differences associated with verbal habits of thought.

scholarly journals The Effect of Baseline Performance and Age on Cognitive Training Improvements in Older Adults: A Qualitative Review

2020 ◽  
pp. 1-10
Author(s):  
J.S. Shaw ◽  
S.M.H. Hosseini
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Individual Differences ◽  
Executive Functioning ◽  
Episodic Memory ◽  
Old Age ◽  
Cognitive Training ◽  
Cognitive Abilities ◽  
Baseline Performance

Findings that the brain is capable of plasticity up until old age have led to interest in the use of cognitive training as a potential intervention to delay the onset of dementia. However, individuals participating in training regimens differ greatly with respect to their outcomes, demonstrating the importance of considering individual differences, in particular age and baseline performance in a cognitive domain, when evaluating the effectiveness of cognitive training. In this review, we summarize existing literature on cognitive training in adults across the domains of episodic memory, working memory and the task-switching component of executive functioning to clarify the picture on the impact of age and baseline performance on cognitive training-related improvements. Studies targeting episodic memory induced greater improvements in younger adults with more intact cognitive abilities, explained in part by factors specific to episodic memory training. By contrast, older, lower baseline performance adults improved most in several studies targeting working memory in older individuals as well as in the majority of studies targeting executive functioning, suggesting the preservation of neural plasticity in these domains until very old age. Our findings can have important implications for informing the design of future interventions for enhancing cognitive functions in individuals at the prodromal stage of Alzheimer’s Disease and potentially delaying the clinical onset of Alzheimer’s Disease. Future research should more clearly stratify individuals according to their baseline cognitive abilities and assign specialized, skill-specific cognitive training regimens in order to directly answer the question of how individual differences impact training effectiveness.

scholarly journals Neural and behavioral correlates of episodic memory are associated with temporal discounting in older adults

2019 ◽  
Author(s):  
Karolina M. Lempert ◽  
Dawn J. Mechanic-Hamilton ◽  
Long Xie ◽  
Laura E.M. Wisse ◽  
Robin de Flores ◽  
...  
Keyword(s):  
Older Adults ◽  
Individual Differences ◽  
Episodic Memory ◽  
Temporal Lobe ◽  
Cortical Thickness ◽  
Medial Temporal Lobe ◽  
Structural Integrity ◽  
Temporal Discounting ◽  
Risk Tolerance ◽  
Trade Offs

AbstractWhen facing decisions involving trade-offs between smaller, sooner and larger, delayed rewards, people tend to discount the value of future rewards. There are substantial individual differences in this tendency toward temporal discounting, however. One neurocognitive system that may underlie these individual differences is episodic memory, given the overlap in the neural circuitry involved in imagining the future and remembering the past. Here we tested this hypothesis in older adults, including both those that were cognitively normal and those with amnestic mild cognitive impairment (MCI). We found that performance on neuropsychological measures of episodic memory retrieval was associated with temporal discounting, such that people with better memory discounted delayed rewards less. This relationship was specific to episodic memory and temporal discounting, since executive function (another cognitive ability) was unrelated to temporal discounting, and episodic memory was unrelated to risk tolerance (another decision-making preference). We also examined cortical thickness and volume in medial temporal lobe regions critical for episodic memory. Entorhinal cortical thickness was associated with reduced temporal discounting, with episodic memory performance partially mediating this association. The inclusion of MCI participants was critical to revealing these associations between episodic memory and entorhinal cortical thickness and temporal discounting. These effects were larger in the MCI group, reduced after controlling for MCI status, and statistically significant only when including MCI participants in analyses. Overall, these findings suggest that individual differences in temporal discounting are driven by episodic memory function, and that a decline in medial temporal lobe structural integrity may impact temporal discounting.

Individual Differences in Value-Directed Remembering

2019 ◽  
Author(s):  
Blake L. Elliott ◽  
Samuel M. McClure ◽  
Gene Arnold Brewer
Keyword(s):  
Working Memory ◽  
Individual Differences ◽  
Episodic Memory ◽  
Structural Equation ◽  
Working Memory Capacity ◽  
Human Memory ◽  
Memory Capacity ◽  
Equation Modeling ◽  
Memory Encoding ◽  
Capacity Limits

Prioritized encoding and retrieval of valuable information is an essential component of human memory due to capacity limits. Individual differences in value-directed encoding may derive from variability in stimulus valuation, memory encoding, or from strategic abilities related to maintenance in working memory. We collected multiple cognitive ability measures to test whether variation in episodic memory, working memory capacity, or both predict differences in value-directed remembering among a large sample of participants (n=205). Confirmatory factor analysis and structural equation modeling was used to assess the contributions of episodic and working memory to value sensitivity in value-directed remembering tasks. Episodic memory ability, but not working memory capacity, was predictive of value-directed remembering. These results suggest that cognitive processes may be differentially related to value-based memory encoding.

scholarly journals The relationship between hippocampal-dependent task performance and hippocampal grey matter myelination and iron content

2021 ◽  
Vol 5 ◽  
pp. 239821282110119
Author(s):  
Ian A. Clark ◽  
Martina F. Callaghan ◽  
Nikolaus Weiskopf ◽  
Eleanor A. Maguire
Keyword(s):  
Individual Differences ◽  
Autobiographical Memory ◽  
Task Performance ◽  
Iron Content ◽  
Grey Matter ◽  
Cognitive Task ◽  
Spatial Navigation ◽  
Imaging Data ◽  
Future Thinking

Individual differences in scene imagination, autobiographical memory recall, future thinking and spatial navigation have long been linked with hippocampal structure in healthy people, although evidence for such relationships is, in fact, mixed. Extant studies have predominantly concentrated on hippocampal volume. However, it is now possible to use quantitative neuroimaging techniques to model different properties of tissue microstructure in vivo such as myelination and iron. Previous work has linked such measures with cognitive task performance, particularly in older adults. Here we investigated whether performance on scene imagination, autobiographical memory, future thinking and spatial navigation tasks was associated with hippocampal grey matter myelination or iron content in young, healthy adult participants. Magnetic resonance imaging data were collected using a multi-parameter mapping protocol (0.8 mm isotropic voxels) from a large sample of 217 people with widely-varying cognitive task scores. We found little evidence that hippocampal grey matter myelination or iron content were related to task performance. This was the case using different analysis methods (voxel-based quantification, partial correlations), when whole brain, hippocampal regions of interest, and posterior:anterior hippocampal ratios were examined, and across different participant sub-groups (divided by gender and task performance). Variations in hippocampal grey matter myelin and iron levels may not, therefore, help to explain individual differences in performance on hippocampal-dependent tasks, at least in young, healthy individuals.

scholarly journals When time's arrow doesn't bend: APOE-ε4 influences episodic memory before old age

2019 ◽  
Vol 133 ◽  
pp. 107180 ◽  
Author(s):  
Teal S. Eich ◽  
Angeliki Tsapanou ◽  
Yaakov Stern
Keyword(s):  
Episodic Memory ◽  
Old Age ◽  
Apoe Ε4 ◽  
Time’S Arrow

“Looking Back, What Period of Your Life Brought You the Most Satisfaction”

1997 ◽  
Vol 45 (3) ◽  
pp. 169-194 ◽  
Author(s):  
Dorothy Field
Keyword(s):  
Individual Differences ◽  
Old Age ◽  
Childhood And Adolescence ◽  
Childhood Memories ◽  
Great Satisfaction ◽  
Men And Women ◽  
Life Period ◽  
Looking Back

Common myths hold that old persons are fixated on childhood memories, that they believe that youth is the best part of life, and that old age contains few satisfactions. Berkeley Older Generation Study members, when asked on two occasions during old age ( M ages = 69.8 and 82.7) to name the periods of their lives that brought them the most and the least satisfaction, dispelled these myths. The thirties and forties were popular choices for periods of great satisfaction, but childhood and adolescence were quite unpopular for these old persons. “Right now” was named more often than any other life period as most satisfactory. Men and women did not differ in life periods nominated, but they did differ in the reasons given for their choices. Each period provided its own pattern of satisfactions and disappointments, and strong individual differences were apparent.

Sign in / Sign up

Export Citation Format

Share Document