scholarly journals Brain Angiopathy and Impaired Glucose Logistics in Mice with Psychosis-related Higher Brain Dysfunction

2020 ◽  
Author(s):  
Shinobu Hirai ◽  
Hideki Miwa ◽  
Tomoko Tanaka ◽  
Kazuya Toriumi ◽  
Yasuto Kunii ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Psychiatric Disorders ◽  
Metabolic Stress ◽  
Brain Dysfunction ◽  
Metabolic Dysfunction ◽  
Brain Glucose ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose ◽  
Higher Brain Dysfunction

AbstractPsychiatric disorders are considered to be associated with metabolic dysfunction; however, it is unclear whether our current high-sugar diet contributes to pathogenesis. We demonstrate that a high-sucrose diet during adolescence induces psychosis-related phenotypes, such as hyperactivity, poor working memory, impaired sensory gating, and disrupted interneuron function, particularly in mice deficient for glyoxalase-1, an enzyme involved in detoxification of sucrose metabolites. Further, the high-sucrose diet induced microcapillary impairment and reduced brain glucose uptake. Aspirin protected against this angiopathy, enhanced brain glucose uptake, and prevented abnormal behavioral phenotypes. The brains of patients with schizophrenia and bipolar disorder exhibited similar angiopathy. Psychiatric disorders are associated with microvascular brain damage, possibly due to various environmental stresses including metabolic stress.

scholarly journals Effect of High Sucrose Diet on Histopathological Indicators Associated With Nonalcoholic Fatty Liver Disease in Male and Female C57bl/6N Mice

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 461-461
Author(s):  
Melissa Vega-Burgueño ◽  
Marcela Vergara-Jiménez ◽  
Lorenzo Osuna-Ramirez ◽  
Edith Torres-Montoya ◽  
José Zazueta-Moreno ◽  
...  
Keyword(s):  
Inflammatory Infiltrate ◽  
Metabolic Stress ◽  
Research Network ◽  
Standard Diet ◽  
Score System ◽  
Male And Female ◽  
Histological Score ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

Abstract Objectives To evaluate the effect of a high sucrose diet on the histopathological indicators related to NAFLD in male and female mice of the C57bl/6N strain. Methods Forty male and female mice of the C57bl/6N strain were randomly divided into four experimental groups: Control male (CMG) and female groups (CFG) with a standard diet (Rodent Chow) and tap water, as well as sucrose male (SMG) and female groups (SFG) which received standard diet and a 50% sucrose water solution. All the groups were fed ad libitum to one of the two different diets for 20 weeks. After 20 weeks, mice were sacrificed. Blood, hepatic and adipose tissues were collected for analyses. Hepatic tissues were sectioned and stained with hematoxylin and eosin. Samples were examined by light microscopy to analyze liver damage. The non-alcoholic steatohepatitis (NASH) degree was determined according to the histological score system proposed by the clinical research network of NASH. Results In hepatic histological samples of MCG, a normal parenchyma formed by hepatocytes with a conserved architecture was observed, in which the cytoplasm and the nucleus can be appreciated. According to the histological score system of the clinical research network of NASH, it was not considered into any NASH grade. FCG showed few microvesicles in parenchyma, developing grade 1 of NASH, with microvesicular steatosis, not considered pathological. Compared to sucrose groups, in MSG were observed presence of moderate microvesicular steatosis, moderate metabolic stress, and glycogen condensation. No presence of inflammatory infiltrate, inflammation, or granulomas, developing grade 4 of NASH. On the other hand, FSG showed a wide spread of macrovesicular steatosis (zones 1, 2 and 3 of liver acinus), presence of inflammatory infiltrate and granulomas in the liver parenchyma. High metabolic stress in the three zones and glycogen condensation, with the loss of histological architecture, positioning in grade 6 of NASH. Conclusions A high sucrose diet contributed to develop NAFLD in mice of the C57bl/6n strain. MSG showed light to moderate degree of NAFLD, whereas FSG showed a moderate to a high degree of NAFLD (steatosis and NASH) related to sucrose consumption. Funding Sources This work was supported by the Universidad Autónoma de Sinaloa.

Hepatic Transcriptomic Signature of High-Sucrose Diet in Nonobese Model of Metabolic Syndrome and Prediabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1723-P
Author(s):  
IRENA MARKOVÁ ◽  
MARTINA HÜTTL ◽  
HANA MALINSKA ◽  
ONDREJ SEDA ◽  
LUDMILA KAZDOVA
Keyword(s):  
Metabolic Syndrome ◽  
Sucrose Diet ◽  
Transcriptomic Signature ◽  
High Sucrose Diet ◽  
High Sucrose

Motor learning impairment in rats under a high sucrose diet

2021 ◽  
Vol 234 ◽  
pp. 113384
Author(s):  
Nayely Flores-Fuentes ◽  
Carolina Hernandez-Cruz ◽  
Karina Bermeo ◽  
Antonio Barajas-Martinez ◽  
Valeria Nayely Hernandez-Serratos ◽  
...  
Keyword(s):  
Motor Learning ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
Learning Impairment ◽  
High Sucrose

scholarly journals Metabolic control of daily locomotor activity mediated by tachykinin in Drosophila

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Sang Hyuk Lee ◽  
Eunjoo Cho ◽  
Sung-Eun Yoon ◽  
Youngjoon Kim ◽  
Eun Young Kim
Keyword(s):  
Locomotor Behavior ◽  
Sensory Inputs ◽  
Sucrose Diet ◽  
High Nutrient ◽  
Intracellular Ca ◽  
High Sucrose Diet ◽  
Locomotor Activities ◽  
Locomotor Behaviors ◽  
High Sucrose ◽  
Over Time

AbstractMetabolism influences locomotor behaviors, but the understanding of neural curcuit control for that is limited. Under standard light-dark cycles, Drosophila exhibits bimodal morning (M) and evening (E) locomotor activities that are controlled by clock neurons. Here, we showed that a high-nutrient diet progressively extended M activity but not E activity. Drosophila tachykinin (DTk) and Tachykinin-like receptor at 86C (TkR86C)-mediated signaling was required for the extension of M activity. DTk neurons were anatomically and functionally connected to the posterior dorsal neuron 1s (DN1ps) in the clock neuronal network. The activation of DTk neurons reduced intracellular Ca2+ levels in DN1ps suggesting an inhibitory connection. The contacts between DN1ps and DTk neurons increased gradually over time in flies fed a high-sucrose diet, consistent with the locomotor behavior. DN1ps have been implicated in integrating environmental sensory inputs (e.g., light and temperature) to control daily locomotor behavior. This study revealed that DN1ps also coordinated nutrient information through DTk signaling to shape daily locomotor behavior.

Effects on Serum Lipids of Different Dietary Fats Associated with a High Sucrose Diet

1973 ◽  
Vol 44 (6) ◽  
pp. 601-604 ◽  
Author(s):  
J. I. Mann ◽  
G. S. Watermeyer ◽  
E. B. Manning ◽  
J. Randles ◽  
A. S. Truswell
Keyword(s):  
Serum Lipids ◽  
Saturated Fat ◽  
Dietary Fats ◽  
Complex Carbohydrate ◽  
The Third ◽  
Sucrose Diet ◽  
Daily Energy ◽  
Dietary Period ◽  
High Sucrose Diet ◽  
High Sucrose

1. Each of nine volunteers was fed three different diets. The percentage of total daily energy provided by fat, carbohydrate and protein remained constant, but the nature of the fat and carbohydrate was altered. The first diet contained ordinary amounts of sucrose and predominantly saturated fat. During the second dietary period, fat remained saturated, but the quantity of sucrose was increased at the expense of complex carbohydrate. In the third dietary period, the sucrose intake remained high, but fat was supplied chiefly in the polyunsaturated form. 2. A small but statistically significant increase of serum fasting cholesterol and triglyceride was observed during the second dietary period, but on the third diet levels of both lipids fell to concentrations not significantly different from those seen on the first diet.

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