scholarly journals Digit ratio (2D:4D) and Congenital Adrenal Hyperplasia (CAH): Systematic Literature Review and Meta-Analysis

2020 ◽  
Author(s):  
Gareth Richards ◽  
Wendy V. Browne ◽  
Ezra Aydin ◽  
Mihaela Constantinescu ◽  
Gideon Nave ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Meta Analysis ◽  
Sex Hormone ◽  
Adrenal Hyperplasia ◽  
Adrenal Androgen ◽  
Left Hand ◽  
Digit Ratios ◽  
Hormone Exposure ◽  
The Right ◽  
The Relationship

AbstractThe ratio of length between the second and fourth fingers (2D:4D) is commonly used as an indicator of prenatal sex hormone exposure. Several approaches have been used to try to validate the measure, including examining 2D:4D in people with congenital adrenal hyperplasia (CAH), a suite of conditions characterised by elevated adrenal androgen production secondary to defective steroidogenesis. We present here a systematic review that examines the relationship between these two variables. Twelve articles relating to nine CAH cohorts were identified, and 2D:4D comparisons have been made between cases and controls in eight of these cohorts. Altogether, at least one 2D:4D variable has been compared between n=251 females with CAH and n=358 unaffected females, and between n=108 males with CAH and n=204 unaffected males. A previous meta-analysis (Hönekopp & Watson, 2010) reported lower right hand (R2D:4D) and left hand (L2D:4D) digit ratios in patients with CAH relative to sex-matched controls. Our meta-analysis showed the same direction of results; however, the effects were only statistically significant for R2D:4D in males and L2D:4D in females (R2D:4D: females, p = 0.072, g = 0.591; males, p = 0.019, g = 0.513; L2D:4D: females, p = 0.020, g = 0.245; males, p = 0.334, g = 0.218), and the average effect size had reduced by 46.70%. We also found no evidence to suggest the right-left difference in 2D:4D (D[R-L]) is associated with prenatal sex hormone exposure.

scholarly journals Digit ratio (2D:4D) and amniotic testosterone and estradiol: an attempted replication of Lutchmaya et al. (2004)

2021 ◽  
pp. 1-6
Author(s):  
Gareth Richards ◽  
Wendy V. Browne ◽  
Mihaela Constantinescu
Keyword(s):  
Amniotic Fluid ◽  
Digit Ratio ◽  
Second Trimester ◽  
Left Hand ◽  
Digit Ratios ◽  
Hormone Exposure ◽  
The Right ◽  
Digit Length ◽  
Attempted Replication

Abstract The ratio of length between the second (index) and fourth (ring) fingers (digit ratio or 2D:4D) is frequently employed as a retrospective marker of prenatal sex hormone exposure. Lutchmaya et al. (2004) reported that the ratio of testosterone (T) to estradiol (E) present in second-trimester amniotic fluid was negatively correlated with digit ratios for the right hand (but not the left hand) in a sample of 29 children at 2-year follow-up. This observation is frequently cited as evidence for the measure’s validity but has not been replicated. We therefore present the findings of another study of amniotic T and E that did not find evidence for these effects at 4½-year follow-up. The confidence intervals were large, the direction of correlations observed was generally erratic, and the overall findings question the premise that second-trimester sex hormones affect the development of digit length ratios in humans.

scholarly journals Digit Ratio (2D:4D) and Amniotic Testosterone and Estradiol: An Attempted Replication of Lutchmaya et al. (2004)

2020 ◽  
Author(s):  
Gareth Richards ◽  
Wendy V. Browne ◽  
Mihaela Constantinescu
Keyword(s):  
Amniotic Fluid ◽  
Digit Ratio ◽  
Second Trimester ◽  
Left Hand ◽  
Digit Ratios ◽  
Hormone Exposure ◽  
The Right ◽  
Digit Length ◽  
Attempted Replication

AbstractThe ratio of length between the second (index) and fourth (ring) fingers (digit ratio or 2D:4D) is frequently employed as a retrospective marker of prenatal sex hormone exposure. Lutchmaya et al. (2004) reported that the ratio of testosterone (T) to estradiol (E) present in second trimester amniotic fluid was negatively correlated with digit ratios for the right hand (but not the left hand) in a sample of 29 children at 2-year follow-up. This observation is frequently cited as evidence for the measure’s validity but has not been replicated. We therefore present the findings of another study of amniotic T and E that did not find evidence for these effects at 4½-year follow-up. The confidence intervals were large, the direction of correlations observed was generally erratic, and the overall findings therefore question the premise that second trimester sex hormones affect the development of digit length ratios in humans.

scholarly journals Digit ratio (2D:4D) and congenital adrenal hyperplasia (CAH): Systematic literature review and meta-analysis

2020 ◽  
Vol 126 ◽  
pp. 104867 ◽  
Author(s):  
Gareth Richards ◽  
Wendy V. Browne ◽  
Ezra Aydin ◽  
Mihaela Constantinescu ◽  
Gideon Nave ◽  
...  
Keyword(s):  
Literature Review ◽  
Congenital Adrenal Hyperplasia ◽  
Systematic Literature Review ◽  
Meta Analysis ◽  
Digit Ratio ◽  
Adrenal Hyperplasia

scholarly journals Giant bilateral adrenal lipoma in a patient with congenital adrenal hyperplasia

2021 ◽  
Vol 2021 ◽  
Author(s):  
Tina Kienitz ◽  
Jörg Schwander ◽  
Ulrich Bogner ◽  
Michael Schwabe ◽  
Thomas Steinmüller ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Abdominal Mass ◽  
Clinical Signs ◽  
Adrenal Tumors ◽  
List Type ◽  
Adrenal Hyperplasia ◽  
Endocrine Society ◽  
Adrenal Imaging ◽  
Open Laparotomy ◽  
The Right

Summary Apart from adrenal myelolipomas, adrenal lipomatous tumors are rare and only seldom described in the literature. We present the case of a 50-year-old man, with a classical form of congenital adrenal hyperplasia (CAH), which was well treated with prednisolone and fludrocortisone. The patient presented with pollakisuria and shortness of breath while bending over. On MRI, fat-equivalent masses were found in the abdomen (14 × 19 × 11 cm on the right side and 10 × 11 × 6 cm on the left side). The right adrenal mass was resected during open laparotomy and the pathohistological examination revealed the diagnosis of an adrenal lipoma. Symptoms were subdued totally postoperatively. This is the first report of a bilateral adrenal lipoma in a patient with CAH that we are aware of. Learning points Macronodular hyperplasia is common in patients with congenital adrenal hyperplasia (CAH). Solitary adrenal tumors appear in approximately 10% of adult CAH patients and are often benign myelolipomas. The Endocrine Society Clinical Practice Guideline does not recommend routine adrenal imaging in adult CAH patients. Adrenal imaging should be performed in CAH patients with clinical signs for an adrenal or abdominal mass. Adrenal lipoma is rare and histopathological examinations should rule out a differentiated liposarcoma.

scholarly journals Management of Altered Hydrocortisone Pharmacokinetics in a Boy with Congenital Adrenal Hyperplasia Using a Continuous Subcutaneous Hydrocortisone Infusion

2009 ◽  
Vol 94 (9) ◽  
pp. 3477-3480 ◽  
Author(s):  
Sinead M. Bryan ◽  
John W. Honour ◽  
Peter C. Hindmarsh
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Insulin Pump ◽  
Serum Cortisol ◽  
Adrenal Hyperplasia ◽  
Adrenal Androgen ◽  
Valuable Adjunct ◽  
Rapid Control ◽  
High Doses ◽  
17 Hydroxyprogesterone ◽  
Oral Doses

Background: Conventional hydrocortisone dosing schedules do not mimic the normal circadian rhythm of cortisol, making it difficult to optimize treatment in congenital adrenal hyperplasia (CAH). Case Details: We report a 14.5-year-old boy with CAH who had reduced bioavailability [42% (normal 80% orally and 100% by im route)] and increased clearance [half-life 50 min (normal range, 70–100 min)] of oral doses of hydrocortisone leading to ambient serum 17-hydroxyprogesterone concentrations of 400 nmol/liter (14.5 ng/ml) and androstenedione concentrations of 24.9 nmol/liter (7.1 ng/ml). Intervention: Using a continuous but variable sc hydrocortisone infusion via an insulin pump, rapid control of his CAH was attained with a normal cortisol circadian profile. Average daily hydrocortisone dose was 17.4–18.6 mg/m2, which produces on average 24-h serum cortisol and 17-hydroxyprogesterone concentrations of 316 nmol/liter (115 ng/ml) and 4.3 nmol/liter (1.4 ng/ml), respectively. Therapy has been maintained over 4 yr with suppression of normal adrenal androgen production and normal progression through puberty. Conclusions: Continuous sc infusion of hydrocortisone may prove a valuable adjunct to therapy for CAH, particularly in patients requiring high doses of oral hydrocortisone and in those with abnormal hydrocortisone pharmacokinetics. A boy is described with congenital adrenal hyperplasia and altered hydrocortisone pharmacokinetics managed by continuous subcutaneous hydrocortisone infusion.

scholarly journals Investigation of the relationship of the morphometric measurements of the hands and fingers with the personality traits of leadership

2019 ◽  
Vol 8 (1) ◽  
pp. 5
Author(s):  
Seda Sertel Meyvaci ◽  
Rengin Kosif ◽  
Murat Diramali ◽  
Tugce Baki
Keyword(s):  
Personality Traits ◽  
Index Finger ◽  
Charismatic Leadership ◽  
Distal Phalanx ◽  
Anthropometric Measurements ◽  
Leadership Frames ◽  
Left Hand ◽  
Leadership Frame ◽  
The Right ◽  
The Relationship

Background: The hand is a functionally critical organ at the distal end of the upper extremity. Also, the creases in the hands and the digital flexion creases on the fingers are the important external anatomical landmarks.Objectives: There are no studies found in the literature, linking solely the leadership personality traits with the anthropometric measurements of the hand.Methods: This descriptive study was to investigate the relationship between the 44 anthropometric measurements about hand, and the leadership personality traits in young adults from both genders.Results: When the leadership frames were compared by the scores, human resource leadership scores were significantly higher in the females. The charismatic leadership frame scores positively correlated with the parameters in males; including the breadth of the right hand, the breadth of the left hand, the index finger length of the left hand, and the distal phalanx length of the index finger on the left hand. The transformational leadership score was positively correlated with the left hand width and with the distal phalanx of the index finger on the left hand. In females, it was found out that the frames of human leadership and charismatic leadership correlated negatively with the length of the right thumb.Conclusions: According to the results of our study, we concluded that the breadth of the hand and the measurements of the thumb and the index fingers can provide opinion on leadership personality traits.  

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