MIND diet associated with later onset of Parkinson's disease

Background: The MIND diet has been linked with prevention of Alzheimer's disease and cognitive decline but has not been fully assessed in the context of Parkinson's disease (PD). Objective: To determine whether MIND diet adherence is associated with the age of Parkinson's disease onset in a manner superior to that of the Mediterranean diet. Methods: Food Frequency Questionnaires from 167 participants with PD and 119 controls were scored for MIND and two versions of Mediterranean diet adherence. Scores were compared between sex and disease subgroups, and PD diet adherence was correlated with age of onset using univariate and multivariate linear models. Results: The female subgroup adhered more closely to the MIND diet than the males, and diet scores were not modified by disease status. Later age of onset correlated most strongly with MIND diet adherence in the female subgroup, corresponding to differences of up to 17.4 years (p<0.001) between low and high dietary tertiles. Greek Mediterranean adherence was also significantly associated with later PD onset across all models (p=0.05-0.03). Conversely, only Greek Mediterranean adherence remained correlated with later onset across all models in men, with differences of up to 8.4 years (p=0.002). Conclusions: This cross-sectional study finds a strong correlation of age of onset of PD with dietary habits, suggesting that nutritional strategies may be an effective tool to delay PD onset. Further studies may help to elucidate potential nutrition-related sex-specific pathophysiological mechanisms and differential prevalence rates in PD.

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Dietary habits in Parkinson's disease: Adherence to Mediterranean diet

Parkinsonism & Related Disorders ◽

10.1016/j.parkreldis.2017.06.007 ◽

2017 ◽

Vol 42 ◽

pp. 40-46 ◽

Cited By ~ 25

Author(s):

Erica Cassani ◽

Michela Barichella ◽

Valentina Ferri ◽

Giovanna Pinelli ◽

Laura Iorio ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Mediterranean Diet ◽

Dietary Habits

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Prevalence and age of onset of Parkinson's disease in Cardiff: a community based cross sectional study and meta-analysis

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp.2008.162222 ◽

2009 ◽

Vol 80 (7) ◽

pp. 805-807 ◽

Cited By ~ 66

Author(s):

M M Wickremaratchi ◽

D Perera ◽

C O'Loghlen ◽

D Sastry ◽

E Morgan ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Age Of Onset ◽

Meta Analysis ◽

Cross Sectional Study ◽

Sectional Study ◽

Community Based ◽

Cross Sectional

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Dietary habits in Parkinson’s disease: adherence to Mediterranean diet

Parkinsonism & Related Disorders ◽

10.1016/j.parkreldis.2017.11.217 ◽

2018 ◽

Vol 46 ◽

pp. e64

Author(s):

E. Cassani ◽

M. Barichella ◽

V. Ferri ◽

G. Pinelli ◽

L. Iorio ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Mediterranean Diet ◽

Dietary Habits

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Study of Physical Fitness, Bone Quality, and Mediterranean Diet Adherence in Professional Female Beach Handball Players: Cross-Sectional Study

Nutrients ◽

10.3390/nu13061911 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1911

Author(s):

Alejandro Martínez-Rodríguez ◽

Javier Sánchez-Sánchez ◽

María Martínez-Olcina ◽

Manuel Vicente-Martínez ◽

Laura Miralles-Amorós ◽

...

Keyword(s):

Physical Fitness ◽

Mediterranean Diet ◽

Dietary Habits ◽

Broadband Ultrasound Attenuation ◽

Future Research ◽

Dominant Hand ◽

Cross Sectional ◽

Diet Adherence ◽

Mediterranean Diet Adherence ◽

The Mediterranean

(1) Background: Beach handball is a relatively new type of sport, derived from team handball. The purpose of the study was to evaluate the physical fitness of elite players of this sport by studying some variables of sports performance, including strength, endurance and power, and dietary habits, and to assess bone ultrasonographic variables. (2) Methods: 33 beach handball players have participated in this research; 18 juniors (age: 16.7 ± 0.50) and 15 seniors (age: 24.8 ± 4.71). The athletes’ strength was evaluated using the Handgrip Test on the dominant hand, the height of jump was evaluated by a counter-jump on a contact platform, and velocity, agility, and resistance by the Yo-Yo test. The broadband ultrasound attenuation (BUA) and the sound of speed (SOS) through the calcaneus were also measured. The Mediterranean diet adherence (KIDMED) was the questionnaire used to evaluate eating habits. In the statistical analysis, descriptions and correlations were made between the study variables. (3) Results: Both in the case of the dynamometric hand strength test (p < 0.05) and in the lower extremity power test (p < 0.01), senior players presented significantly higher values compared to junior players (35.1 ± 3.84 vs. 31.8 ± 3.37 and 35.1 ± 6.89 vs. 28.5 ± 5.69 with the dynamometry and Abalakov tests, respectively). However, no differences were observed in the variables by playing position. Significant correlations between different variables have been established, highlighting negative correlations between BMI and weight with the Abalakov Jump Test and positive correlations between Yo-Yo and BUA, and, between BMI and BUA. (4) Conclusions: Older and trained players are in better physical fitness; high weight and BMI have a negative influence on power, agility, speed, and endurance. In general, adherence to the Mediterranean diet is moderate and it seems evident that there is a beneficial influence of beach handball on bone condition, as measured by ultrasound. However future research should be carried on, including dual-energy x-ray absorptiometry assessments and food intake registers for a whole week.

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The Trajectory of Motor Deterioration to Death in Parkinson's Disease

Frontiers in Neurology ◽

10.3389/fneur.2021.670567 ◽

2021 ◽

Vol 12 ◽

Author(s):

Sabrina Poonja ◽

Janis Miyasaki ◽

Xilai Fu ◽

Richard Camicioli ◽

Tina Sang ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Survival Time ◽

Rating Scale ◽

Age Of Onset ◽

Piecewise Linear ◽

Disease Onset ◽

Retrospective Chart Review ◽

Disease Diagnosis ◽

Course Of Illness

Background: Motor progression varies even among those with a single diagnosis such as Parkinson's disease (PD) and little is known about the trajectory of motor signs prior to death. Understanding deterioration patterns may help clinicians counsel patients and proactively plan interdisciplinary care, including palliative care. The objective of this study was to examine and describe Unified Parkinson's Disease Rating Scale motor score (UPDRS-III) trajectories at the end of life in PD.Methods: A retrospective chart review was performed for deceased PD patients who attended the Parkinson and Movement Disorders Program at the University of Alberta for at least 5 years between 1999 and 2018. UPDRS-III scores were recorded for all visits. Trajectory patterns were visualized with Loess curves stratified by sex and age at diagnosis. Piecewise linear models were used to individually model the UPDRS-III scores, and the trajectories obtained were clustered based on their features.Results: Among the 202 charts reviewed, 84 meeting inclusion criteria were analyzed. The UPDRS-III increased over time regardless of sex and age. Distinct trajectory variations present in PD (e.g., Consistent Deterioration, Stability-Deterioration, Improvement-Deterioration, Deterioration-Improvement-Deterioration) were identified. Twenty-five percent of the patients were classified as Undetermined/Irregular trajectories. In addition, regardless of trajectory type, many patients experienced a steep increase in UPDRS-III approaching death. Those with disease diagnosis after age 65 years had a shorter survival time, compared to PD patients with a younger age of onset.Conclusion: Our study identified dominant types of motor trajectory in PD that can help clinicians understand their patients' course of illness. This information can help counsel patients regarding the variability in motor deterioration and should alert physicians to recognize a terminal decline. Age of disease onset was correlated with survival time.

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The association between Mediterranean diet adherence and Parkinson's disease

Movement Disorders ◽

10.1002/mds.24918 ◽

2012 ◽

Vol 27 (6) ◽

pp. 771-774 ◽

Cited By ~ 90

Author(s):

Roy N. Alcalay ◽

Yian Gu ◽

Helen Mejia-Santana ◽

Lucien Cote ◽

Karen S. Marder ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Mediterranean Diet ◽

Diet Adherence ◽

Mediterranean Diet Adherence

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Dietary Variations in a Multiethnic Parkinson’s Disease Cohort and Possible Influences on Nonmotor Aspects: A Cross-Sectional Multicentre Study

Parkinson s Disease ◽

10.1155/2018/7274085 ◽

2018 ◽

Vol 2018 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Anna Sauerbier ◽

Anette Schrag ◽

Pablo Martinez-Martin ◽

Lynsey J. Hall ◽

Miriam Parry ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Dietary Habits ◽

Depression Scale ◽

Dietary Factors ◽

Recruitment Strategy ◽

Nonmotor Symptoms ◽

Cross Sectional ◽

Medicine Research ◽

Supplement Use

Dietary habits may differ between Parkinson’s disease (PD) patients of different ethnicities. The primary aim of this cross-sectional analysis was to compare dietary habits in a multiethnic PD population and investigate potential nonmotor differences. All patients completed a dietary habits questionnaire. Besides basic demographics, patients’ motor involvement (Hoehn and Yahr (HY)) and nonmotor symptoms (Nonmotor Symptoms Scale; Hospital Anxiety and Depression Scale) were assessed. 139 PD patients were included (mean age 66.8 ± 11.6 years; 61.2% male; mean disease duration 6.2 ± 5.2 years; median HY 3): 47.5% were White, 24.5% Asian, and 28.0% Black African and Caribbean (BAC). We found dietary differences between the groups, including a greater frequency of vegetarians and greater consumption of cumin, turmeric, and cinnamon as well as lower consumption of beef in Asian patients than in White and BAC and greater consumption of chili than in White patients and higher consumption of pork in White than Asian and BAC patients. There were no significant differences in dietary supplement consumption after correction for multiple comparisons. None of the dietary factors examined were associated with differences in nonmotor symptoms. Diet and supplement use vary in PD patients across ethnicities, this is both a problem and opportunity for nutritional medicine research. These data support the importance of considering ethnic diversity as part of recruitment strategy in nutrition and clinical studies.

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