scholarly journals A convolutional neural network for common coordinate registration of high-resolution histology images

2020 ◽  
Author(s):  
Aidan C. Daly ◽  
Krzysztof J. Geras ◽  
Richard A. Bonneau

AbstractRegistration of histology images from multiple sources is a pressing problem in large-scale studies of spatial -omics data. Researchers often perform “common coordinate registration,” akin to segmentation, in which samples are partitioned based on tissue type to allow for quantitative comparison of similar regions across samples. Accuracy in such registration requires both high image resolution and global awareness, which mark a difficult balancing act for contemporary deep learning architectures. We present a novel convolutional neural network (CNN) architecture that combines (1) a local classification CNN that extracts features from image patches sampled sparsely across the tissue surface, and (2) a global segmentation CNN that operates on these extracted features. This hybrid network can be trained in an end-to-end manner, and we demonstrate its relative merits over competing approaches on a reference histology dataset as well as two published spatial transcriptomics datasets. We believe that this paradigm will greatly enhance our ability to process spatial -omics data, and has general purpose applications for the processing of high-resolution histology images on commercially available GPUs.

2020 ◽  
Vol 12 (8) ◽  
pp. 1288 ◽  
Author(s):  
José R. G. Braga ◽  
Vinícius Peripato ◽  
Ricardo Dalagnol ◽  
Matheus P. Ferreira ◽  
Yuliya Tarabalka ◽  
...  

Tropical forests concentrate the largest diversity of species on the planet and play a key role in maintaining environmental processes. Due to the importance of those forests, there is growing interest in mapping their components and getting information at an individual tree level to conduct reliable satellite-based forest inventory for biomass and species distribution qualification. Individual tree crown information could be manually gathered from high resolution satellite images; however, to achieve this task at large-scale, an algorithm to identify and delineate each tree crown individually, with high accuracy, is a prerequisite. In this study, we propose the application of a convolutional neural network—Mask R-CNN algorithm—to perform the tree crown detection and delineation. The algorithm uses very high-resolution satellite images from tropical forests. The results obtained are promising—the R e c a l l , P r e c i s i o n , and F 1 score values obtained were were 0.81 , 0.91 , and 0.86 , respectively. In the study site, the total of tree crowns delineated was 59,062 . These results suggest that this algorithm can be used to assist the planning and conduction of forest inventories. As the algorithm is based on a Deep Learning approach, it can be systematically trained and used for other regions.


2019 ◽  
Vol 19 (4) ◽  
pp. 1003-1016 ◽  
Author(s):  
Yasamin Keshmiri Esfandabadi ◽  
Maxime Bilodeau ◽  
Patrice Masson ◽  
Luca De Marchi

Ultrasonic wavefield imaging with a non-contact technology can provide detailed information about the health status of an inspected structure. However, high spatial resolution, often necessary for accurate damage quantification, typically demands a long scanning time. In this work, we investigate a novel methodology to acquire high-resolution wavefields with a reduced number of measurement points to minimize the acquisition time. Such methodology is based on the combination of compressive sensing and convolutional neural networks to recover high spatial frequency information from low-resolution images. A data set was built from 652 wavefield images acquired with a laser Doppler vibrometer describing guided ultrasonic wave propagation in eight different structures, with and without various simulated defects. Out of those 652 images, 326 cases without defect and 326 cases with defect were used as a training database for the convolutional neural network. In addition, 273 wavefield images were used as a testing database to validate the proposed methodology. For quantitative evaluation, two image quality metrics were calculated and compared to those achieved with different recovery methods or by training the convolutional neural network with non-wavefield images data set. The results demonstrate the capability of the technique for enhancing image resolution and quality, as well as similarity to the wavefield acquired on the full high-resolution grid of scan points, while reducing the number of measurement points down to 10% of the number of scan points for a full grid.


Informatics ◽  
2020 ◽  
Vol 17 (2) ◽  
pp. 7-16
Author(s):  
R. P. Bohush ◽  
I. Yu. Zakharava ◽  
S. V. Ablameyko

In the paper the algorithm for object detection in high resolution images is proposed. The approach uses multiscale image representation followed by block processing with the overlapping value. For each block the object detection with convolutional neural network was performed. Number of pyramid layers is limited by the Convolutional Neural Network layer size and input image resolution. Overlapping blocks splitting to improve the classification and detection accuracy is performed on each layer of pyramid except the highest one. Detected areas are merged into one if they have high overlapping value and the same class. Experimental results for the algorithm are presented in the paper.


2019 ◽  
Vol 11 (3) ◽  
pp. 272 ◽  
Author(s):  
Nan Mo ◽  
Li Yan ◽  
Ruixi Zhu ◽  
Hong Xie

In this paper, the problem of multi-scale geospatial object detection in High Resolution Remote Sensing Images (HRRSI) is tackled. The different flight heights, shooting angles and sizes of geographic objects in the HRRSI lead to large scale variance in geographic objects. The inappropriate anchor size to propose the objects and the indiscriminative ability of features for describing the objects are the main causes of missing detection and false detection in multi-scale geographic object detection. To address these challenges, we propose a class-specific anchor based and context-guided multi-class object detection method with a convolutional neural network (CNN), which can be divided into two parts: a class-specific anchor based region proposal network (RPN) and a discriminative feature with a context information classification network. A class-specific anchor block providing better initial values for RPN is proposed to generate the anchor of the most suitable scale for each category in order to increase the recall ratio. Meanwhile, we proposed to incorporate the context information into the original convolutional feature to improve the discriminative ability of the features and increase classification accuracy. Considering the quality of samples for classification, the soft filter is proposed to select effective boxes to improve the diversity of the samples for the classifier and avoid missing or false detection to some extent. We also introduced the focal loss in order to improve the classifier in classifying the hard samples. The proposed method is tested on a benchmark dataset of ten classes to prove the superiority. The proposed method outperforms some state-of-the-art methods with a mean average precision (mAP) of 90.4% and better detects the multi-scale objects, especially when objects show a minor shape change.


2020 ◽  
Vol 2020 (10) ◽  
pp. 181-1-181-7
Author(s):  
Takahiro Kudo ◽  
Takanori Fujisawa ◽  
Takuro Yamaguchi ◽  
Masaaki Ikehara

Image deconvolution has been an important issue recently. It has two kinds of approaches: non-blind and blind. Non-blind deconvolution is a classic problem of image deblurring, which assumes that the PSF is known and does not change universally in space. Recently, Convolutional Neural Network (CNN) has been used for non-blind deconvolution. Though CNNs can deal with complex changes for unknown images, some CNN-based conventional methods can only handle small PSFs and does not consider the use of large PSFs in the real world. In this paper we propose a non-blind deconvolution framework based on a CNN that can remove large scale ringing in a deblurred image. Our method has three key points. The first is that our network architecture is able to preserve both large and small features in the image. The second is that the training dataset is created to preserve the details. The third is that we extend the images to minimize the effects of large ringing on the image borders. In our experiments, we used three kinds of large PSFs and were able to observe high-precision results from our method both quantitatively and qualitatively.


Sensors ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 2852
Author(s):  
Parvathaneni Naga Srinivasu ◽  
Jalluri Gnana SivaSai ◽  
Muhammad Fazal Ijaz ◽  
Akash Kumar Bhoi ◽  
Wonjoon Kim ◽  
...  

Deep learning models are efficient in learning the features that assist in understanding complex patterns precisely. This study proposed a computerized process of classifying skin disease through deep learning based MobileNet V2 and Long Short Term Memory (LSTM). The MobileNet V2 model proved to be efficient with a better accuracy that can work on lightweight computational devices. The proposed model is efficient in maintaining stateful information for precise predictions. A grey-level co-occurrence matrix is used for assessing the progress of diseased growth. The performance has been compared against other state-of-the-art models such as Fine-Tuned Neural Networks (FTNN), Convolutional Neural Network (CNN), Very Deep Convolutional Networks for Large-Scale Image Recognition developed by Visual Geometry Group (VGG), and convolutional neural network architecture that expanded with few changes. The HAM10000 dataset is used and the proposed method has outperformed other methods with more than 85% accuracy. Its robustness in recognizing the affected region much faster with almost 2× lesser computations than the conventional MobileNet model results in minimal computational efforts. Furthermore, a mobile application is designed for instant and proper action. It helps the patient and dermatologists identify the type of disease from the affected region’s image at the initial stage of the skin disease. These findings suggest that the proposed system can help general practitioners efficiently and effectively diagnose skin conditions, thereby reducing further complications and morbidity.


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