scholarly journals NeuroPM toolbox: integrating Molecular, Neuroimaging and Clinical data for Characterizing Neuropathological Progression and Individual Therapeutic Needs

2020 ◽  
Author(s):  
Yasser Iturria-Medina ◽  
Felix Carbonell ◽  
Atoussa Assadi ◽  
Quadri Adewale ◽  
Ahmed F. Khan ◽  
...  
Keyword(s):  
Open Access ◽  
High Performance ◽  
Large Scale ◽  
Synergistic Interactions ◽  
Academic Researchers ◽  
Cross Platform ◽  
Therapeutic Needs ◽  
User Friendly ◽  
Performance Computing

There is a critical need for a better multiscale and multifactorial understanding of neurological disorders, covering from genes to neuroimaging to clinical factors and treatments effects. Here we present NeuroPM-box, a cross-platform, user-friendly and open-access software for characterizing multiscale and multifactorial brain pathological mechanisms and identifying individual therapeutic needs. The implemented methods have been extensively tested and validated in the neurodegenerative context, but there is not restriction in the kind of disorders that can be analyzed. By using advanced analytic modeling of molecular, neuroimaging and/or cognitive/behavioral data, this framework allows multiple applications, including characterization of: (i) the series of sequential states (e.g. transcriptomic, imaging or clinical alterations) covering decades of disease progression, (ii) intra-brain spreading of pathological factors (e.g. amyloid and tau misfolded proteins), (iii) synergistic interactions between multiple brain biological factors (e.g. direct tau effects on vascular and structural properties), and (iv) biologically-defined patients stratification based on therapeutic needs (i.e. optimum treatments for each patient). All models outputs are biologically interpretable. A 4D-viewer allows visualization of spatiotemporal brain (dis)organization. Originally implemented in MATLAB, NeuroPM-box is compiled as standalone application for Windows, Linux and Mac environments: neuropm-lab.com/software. In a regular workstation, it can analyze over 150 subjects per day, reducing the need for using clusters or High-Performance Computing (HPC) for large-scale datasets. This open-access tool for academic researchers may significantly contribute to a better understanding of complex brain processes and to accelerating the implementation of Precision Medicine (PM) in neurology.

scholarly journals Integrating molecular, histopathological, neuroimaging and clinical neuroscience data with NeuroPM-box

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Yasser Iturria-Medina ◽  
Félix Carbonell ◽  
Atousa Assadi ◽  
Quadri Adewale ◽  
Ahmed F. Khan ◽  
...  
Keyword(s):  
Alpha Synuclein ◽  
Clinical Neuroscience ◽  
Disease Heterogeneity ◽  
Synergistic Interactions ◽  
Clinical Evaluations ◽  
Cross Platform ◽  
Therapeutic Needs ◽  
User Friendly ◽  
Synuclein Proteins

AbstractUnderstanding and treating heterogeneous brain disorders requires specialized techniques spanning genetics, proteomics, and neuroimaging. Designed to meet this need, NeuroPM-box is a user-friendly, open-access, multi-tool cross-platform software capable of characterizing multiscale and multifactorial neuropathological mechanisms. Using advanced analytical modeling for molecular, histopathological, brain-imaging and/or clinical evaluations, this framework has multiple applications, validated here with synthetic (N > 2900), in-vivo (N = 911) and post-mortem (N = 736) neurodegenerative data, and including the ability to characterize: (i) the series of sequential states (genetic, histopathological, imaging or clinical alterations) covering decades of disease progression, (ii) concurrent intra-brain spreading of pathological factors (e.g., amyloid, tau and alpha-synuclein proteins), (iii) synergistic interactions between multiple biological factors (e.g., toxic tau effects on brain atrophy), and (iv) biologically-defined patient stratification based on disease heterogeneity and/or therapeutic needs. This freely available toolbox (neuropm-lab.com/neuropm-box.html) could contribute significantly to a better understanding of complex brain processes and accelerating the implementation of Precision Medicine in Neurology.

scholarly journals Fast Playback Framework for Analysis of Ground-Based Doppler Radar Observations Using MapReduce Technology

2016 ◽  
Vol 33 (4) ◽  
pp. 621-634 ◽  
Author(s):  
Jingyin Tang ◽  
Corene J. Matyas
Keyword(s):  
Spatial Analysis ◽  
High Performance ◽  
Large Scale ◽  
Doppler Radar ◽  
Weather Events ◽  
Data Architecture ◽  
Research Grade ◽  
High Performance Computing Cluster ◽  
Time Systems ◽  
Performance Computing

AbstractThe creation of a 3D mosaic is often the first step when using the high-spatial- and temporal-resolution data produced by ground-based radars. Efficient yet accurate methods are needed to mosaic data from dozens of radar to better understand the precipitation processes in synoptic-scale systems such as tropical cyclones. Research-grade radar mosaic methods of analyzing historical weather events should utilize data from both sides of a moving temporal window and process them in a flexible data architecture that is not available in most stand-alone software tools or real-time systems. Thus, these historical analyses require a different strategy for optimizing flexibility and scalability by removing time constraints from the design. This paper presents a MapReduce-based playback framework using Apache Spark’s computational engine to interpolate large volumes of radar reflectivity and velocity data onto 3D grids. Designed as being friendly to use on a high-performance computing cluster, these methods may also be executed on a low-end configured machine. A protocol is designed to enable interoperability with GIS and spatial analysis functions in this framework. Open-source software is utilized to enhance radar usability in the nonspecialist community. Case studies during a tropical cyclone landfall shows this framework’s capability of efficiently creating a large-scale high-resolution 3D radar mosaic with the integration of GIS functions for spatial analysis.

scholarly journals High-Performance Computing Framework Based on Distributed Systems for Large-Scale Neurophysiological Data

2021 ◽  
Author(s):  
Mohsen Hadianpour ◽  
Ehsan Rezayat ◽  
Mohammad-Reza Dehaqani
Keyword(s):  
High Performance Computing ◽  
High Performance ◽  
Large Scale ◽  
Electrophysiological Recording ◽  
Neural Data ◽  
Data Framework ◽  
Neurophysiological Data ◽  
Computing Framework ◽  
Performance Computing ◽  
Neuroscience Community

Abstract Due to the significantly drastic progress and improvement in neurophysiological recording technologies, neuroscientists have faced various complexities dealing with unstructured large-scale neural data. In the neuroscience community, these complexities could create serious bottlenecks in storing, sharing, and processing neural datasets. In this article, we developed a distributed high-performance computing (HPC) framework called `Big neuronal data framework' (BNDF), to overcome these complexities. BNDF is based on open-source big data frameworks, Hadoop and Spark providing a flexible and scalable structure. We examined BNDF on three different large-scale electrophysiological recording datasets from nonhuman primate’s brains. Our results exhibited faster runtimes with scalability due to the distributed nature of BNDF. We compared BNDF results to a widely used platform like MATLAB in an equitable computational resource. Compared with other similar methods, using BNDF provides more than five times faster performance in spike sorting as a usual neuroscience application.

scholarly journals Taxonomic assignment for large-scale metagenomic data on high-perfomance systems

2017 ◽  
Vol 33 (2) ◽  
pp. 119-130
Author(s):  
Vinh Van Le ◽  
Hoai Van Tran ◽  
Hieu Ngoc Duong ◽  
Giang Xuan Bui ◽  
Lang Van Tran
Keyword(s):  
High Performance Computing ◽  
Assignment Problem ◽  
High Performance ◽  
Large Scale ◽  
Computing System ◽  
Metagenomic Data ◽  
Taxonomic Assignment ◽  
High Performance Computing System ◽  
Powerful Approach ◽  
Performance Computing

Metagenomics is a powerful approach to study environment samples which do not require the isolation and cultivation of individual organisms. One of the essential tasks in a metagenomic project is to identify the origin of reads, referred to as taxonomic assignment. Due to the fact that each metagenomic project has to analyze large-scale datasets, the metatenomic assignment is very much computation intensive. This study proposes a parallel algorithm for the taxonomic assignment problem, called SeMetaPL, which aims to deal with the computational challenge. The proposed algorithm is evaluated with both simulated and real datasets on a high performance computing system. Experimental results demonstrate that the algorithm is able to achieve good performance and utilize resources of the system efficiently. The software implementing the algorithm and all test datasets can be downloaded at http://it.hcmute.edu.vn/bioinfo/metapro/SeMetaPL.html.

Cloud Computing for Scientific Simulation and High Performance Computing

2013 ◽  
pp. 51-70
Author(s):  
Adrian Jackson ◽  
Michèle Weiland
Keyword(s):  
Cloud Computing ◽  
High Performance Computing ◽  
High Performance ◽  
Large Scale ◽  
Parallel Programs ◽  
Small Scale ◽  
Cloud Infrastructure ◽  
Scientific Simulations ◽  
Cloud Infrastructures ◽  
Performance Computing

This chapter describes experiences using Cloud infrastructures for scientific computing, both for serial and parallel computing. Amazon’s High Performance Computing (HPC) Cloud computing resources were compared to traditional HPC resources to quantify performance as well as assessing the complexity and cost of using the Cloud. Furthermore, a shared Cloud infrastructure is compared to standard desktop resources for scientific simulations. Whilst this is only a small scale evaluation these Cloud offerings, it does allow some conclusions to be drawn, particularly that the Cloud can currently not match the parallel performance of dedicated HPC machines for large scale parallel programs but can match the serial performance of standard computing resources for serial and small scale parallel programs. Also, the shared Cloud infrastructure cannot match dedicated computing resources for low level benchmarks, although for an actual scientific code, performance is comparable.

Green Computing

2014 ◽  
pp. 248-260
Keyword(s):  
Climate Change ◽  
Cloud Computing ◽  
High Performance Computing ◽  
High Performance ◽  
Large Scale ◽  
Green Computing ◽  
Research Topic ◽  
The Other ◽  
Cloud Infrastructures ◽  
Performance Computing

Green computing is a contemporary research topic to address climate and energy challenges. In this chapter, the authors envision the duality of green computing with technological trends in other fields of computing such as High Performance Computing (HPC) and cloud computing on one hand and economy and business on the other hand. For instance, in order to provide electricity for large-scale cloud infrastructures and to reach exascale computing, we need huge amounts of energy. Thus, green computing is a challenge for the future of cloud computing and HPC. Alternatively, clouds and HPC provide solutions for green computing and climate change. In this chapter, the authors discuss this proposition by looking at the technology in detail.

Synchronizing Execution of Big Data in Distributed and Parallelized Environments

Big Data ◽  
2016 ◽  
pp. 1555-1581
Author(s):  
Gueyoung Jung ◽  
Tridib Mukherjee
Keyword(s):  
Big Data ◽  
Distributed System ◽  
Data Analytics ◽  
High Performance ◽  
Large Scale ◽  
Big Data Analytics ◽  
Loosely Coupled ◽  
Current Trends ◽  
Distributed Computing Infrastructures ◽  
Performance Computing

In the modern information era, the amount of data has exploded. Current trends further indicate exponential growth of data in the future. This prevalent humungous amount of data—referred to as big data—has given rise to the problem of finding the “needle in the haystack” (i.e., extracting meaningful information from big data). Many researchers and practitioners are focusing on big data analytics to address the problem. One of the major issues in this regard is the computation requirement of big data analytics. In recent years, the proliferation of many loosely coupled distributed computing infrastructures (e.g., modern public, private, and hybrid clouds, high performance computing clusters, and grids) have enabled high computing capability to be offered for large-scale computation. This has allowed the execution of the big data analytics to gather pace in recent years across organizations and enterprises. However, even with the high computing capability, it is a big challenge to efficiently extract valuable information from vast astronomical data. Hence, we require unforeseen scalability of performance to deal with the execution of big data analytics. A big question in this regard is how to maximally leverage the high computing capabilities from the aforementioned loosely coupled distributed infrastructure to ensure fast and accurate execution of big data analytics. In this regard, this chapter focuses on synchronous parallelization of big data analytics over a distributed system environment to optimize performance.

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