scholarly journals Glycyrrhizin effectively neutralizes SARS-CoV-2 in vitro by inhibiting the viral main protease

2020 ◽  
Author(s):  
L. van de Sand ◽  
M. Bormann ◽  
M. Alt ◽  
L. Schipper ◽  
C.S. Heilingloh ◽  
...  
Keyword(s):  
Licorice Root ◽  
Viral Diseases ◽  
Root Extract ◽  
Traditional Herbal Medicine ◽  
Complementary Treatment ◽  
Antiviral Compound ◽  
Viral Neutralization ◽  
Main Protease ◽  
Licorice Root Extract

AbstractThe newly emerged coronavirus, which was designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 disease. High effective and well-tolerated medication for hospitalized and non-hospitalized patients is urgently needed. Traditional herbal medicine substances were discussed as promising candidates for the complementary treatment of viral diseases and recently suggested for the treatment of COVID-19. In the present study, we investigated aqueous licorice root extract for its neutralizing activity against SARS-CoV-2 in vitro, identified the active compound glycyrrhizin and uncovered the respective mechanism of viral neutralization. We demonstrated that glycyrrhizin, the primary active ingredient of the licorice root, potently neutralizes SARS-CoV-2 by inhibiting the viral main protease. Our experiments highlight glycyrrhizin as a potential antiviral compound that should be further investigated for the treatment of COVID-19.

Jet-spray apparatus for drying licorice root extract

1969 ◽  
Vol 3 (11) ◽  
pp. 665-667
Author(s):  
V. V. Davituliani ◽  
V. I. Ganuchukov
Keyword(s):  
Licorice Root ◽  
Root Extract ◽  
Licorice Root Extract

scholarly journals PENAMBATAN MOLEKUL GLUTATION FAUNA LAUT TERHADAP RESEPTOR DARI BEBERAPA PENYAKIT VIRUS

2021 ◽  
Vol 9 (2) ◽  
pp. 53
Author(s):  
Q Xaxa Alvin Kai ◽  
Inneke FM Rumengan ◽  
Rosita AJ Lintang ◽  
Stenly Wullur ◽  
Deiske A Sumilat ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Gibbs Energy ◽  
Antiviral Drug ◽  
Bond Distance ◽  
Viral Diseases ◽  
Clinical Test ◽  
Marine Fauna ◽  
Antiviral Compound

Glutathion is a tripeptides produced by almost all living creatures, including marine fauna such as rotifers and shrimps. Judging from the important molecular role of glutathion in living cell,  the ability of glutathion as antiviral compound, has been assed by application of the AutodockTools to predict the ability of glutathion as ligand to bind receptors of several viral diseases such as  covid-19, malaria, and hepatitis B. Docking results of glutathion toward target receptor were shown by the parameter, Gibbs energy value, and supported by other data such as the amount of hidrogen bond, amino acid residues, and bond distance. Evidently, the glutathion could bind to  each receptor of covid-19, malaria and hepatitis B, with values of  Gibbs energy (∆G), -7,9, 7,1 and -7,1 kcal/mol, respectively. This proves that glutathion has ability to bind covid-19 receptor, even stronger than its ability to bind receptors of other viral diseases, and to the remdesevir. Between glutathion and covid-19 receptor, there were 11 hidrogen bonds, with distance ranged from 2,76 to 3,25 Å. These were stronger than those between glutathion and receptors of malaria and hepatitis B, only  8 and 4 Å hidrogen bonds, respectively.  To develop glutathion as antiviral drug, it is necessary to carry out in vitro and in vivo analyses, prior to clinical test. Therefore, it requires to explore the marine fauna species that produce glutathion and their cultivation.Keywords: molecular docking, glutathion, marine fauna, autodock vina, viral diseases, binding affinity

Identification and quantification of isoflavonoid and triterpenoid compliance markers in a licorice-root extract powder

1993 ◽  
Vol 41 (1) ◽  
pp. 42-47 ◽  
Author(s):  
David S. Weinberg ◽  
M. Lisa. Mainer ◽  
Mark D. Richardson ◽  
Frederick G. Haibach
Keyword(s):  
Licorice Root ◽  
Root Extract ◽  
Licorice Root Extract ◽  
Identification And Quantification

scholarly journals AMELIORATION OF NECROSIS FORMATION IN GINGIVA BY LICORICE ROOT EXTRACT

2018 ◽  
Vol 11 (10) ◽  
pp. 137
Author(s):  
Shivanni Ss ◽  
Vishnu Priya V ◽  
Gayathri R
Keyword(s):  
Licorice Root ◽  
Tnf Alpha ◽  
Root Extract ◽  
Reactive Protein ◽  
Commercial Source ◽  
Bacterial Plaque ◽  
Reversible Condition ◽  
Hepatocyte Growth ◽  
Necrosis Factor ◽  
Licorice Root Extract

Objective: Gingivitis is a reversible condition associated with a bacterial plaque that resolves in about 1 week after the reinstitution of oral hygiene procedures. If left untreated, may ultimately progress to periodontitis in a subset of individuals. The objective of the study was to evaluate the amelioration of necrosis formation in gingiva by Licorice root extract. The licorice compounds, licoricidin, and licorisoflavan A were the most effective antibacterial substances.Methods: Licorice root extract was prepared by macerating 50 g of dry powder with 100 ml of 70% (w/v) ethyl alcohol for a week. Human gingival fibroblasts were obtained from a commercial source and were maintained in serum-free fibroblast medium as recommended by the manufacturer. The cells were treated with licorice root extract (100 μg/ml) and incubated for 48 h. Tumor necrosis factor (TNF) and C-reactive protein (CRP) were estimated.Result: TNF-alpha levels were raised, and agglutination of CRP was observed in hepatocyte growth factor positive samples whereas after the treatment with licorice root extract the TNF-alpha levels were declined and no agglutination was seen.Conclusion: TNF and CRP levels are raised during necrosis formation. These levels are decreased when treated with licorice root extract. Thus, licorice root extract causes amelioration of necrosis formation in the gingiva.

Identification and quantification of anticarcinogens in garlic extract and licorice root extract powder

1992 ◽  
Vol 15 (10) ◽  
pp. 641-654 ◽  
Author(s):  
David S. Weinberg ◽  
M. Lisa Manier ◽  
Mark D. Richardson ◽  
Frederick G. Haibach ◽  
Tina S. Rogers
Keyword(s):  
Garlic Extract ◽  
Licorice Root ◽  
Root Extract ◽  
Licorice Root Extract ◽  
Identification And Quantification
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