scholarly journals Introductions and evolutions of SARS-CoV-2 strains in Japan

2021 ◽  
Author(s):  
Reitaro Tokumasu ◽  
Dilhan Weeraratne ◽  
Jane Snowdon ◽  
Laxmi Parida ◽  
Michiharu Kudo ◽  
...  
Keyword(s):  
South African ◽  
Temporal Evolution ◽  
Selective Advantage ◽  
Cross Border ◽  
Health Measures ◽  
The United Kingdom ◽  
New Public Health ◽  
New Public ◽  
Deadly Disease ◽  
Border Surveillance

AbstractCOVID-19 caused by SARS-CoV-2 was first identified in Japan on January 15th, 2020, soon after the pandemic originated in Wuhan, China. Subsequently, Japan experienced three distinct waves of the outbreak in the span of a year and has been attributed to new exogenous strains and evolving existing strains. Japan engaged very early on in tracking different COVID-19 sub-strains and have sequenced approximately 5% of all confirmed cases. While Japan has enforced stringent airport surveillance on cross-border travelers and returnees, some carriers appear to have advanced through the quarantine stations undetected. In this study, 17112 genomes sampled in Japan were analyzed to understand the strains, heterogeneity and temporal evolution of different SARS-CoV-2 strains. We identified 11 discrete strains with a substantial number of cases with most strains possessing the spike (S) D614G and nucleocapsid (N) 203_204delinsKR mutations. Besides these variants, ORF1ab P3371S, A4815V, S1361P, and N P151L were also detected in nearly half the samples constituting the most common strain in Japan. 115 distinct strains have been introduced into Japan and 12 of them were introduced after strict quarantine policy was implemented. In particular, the B.1.1.7 strain, that emerged in the United Kingdom (UK) in September 2020, has been circulating in Japan since late 2020 after eluding cross-border quarantine stations. Similarly, the B.1.351 strain dubbed the South African variant, P.1 Brazilian strain and R.1 strain with the spike E484K mutation have been detected in Japan. At least four exogenous B.1.1.7 sub-strains have been independently introduced in Japan as of late January 2021, and these strains carry mutations that give selective advantage including N501Y, H69_V70del, and E484K that confer increased transmissibility, reduced efficacy to vaccines and possible increased virulence. It is imperative that the quarantine policy be revised, cross-border surveillance reinforced, and new public health measures implemented to mitigate further transmission of this deadly disease and to identify strains that may engender resistance to vaccines.

More about Diamonds

2019 ◽  
pp. 115-119
Author(s):  
Vladimir Shubin
Keyword(s):  
United Kingdom ◽  
South African ◽  
Personal Experience ◽  
African Studies ◽  
Short Term ◽  
Soviet State ◽  
The United Kingdom ◽  
De Beers

The article is a rejoinder to the work of Yury S. Skubko, previously published in the Journal of the Institute for African Studies, on Moscow’s relations with De Beers. It is based not only on the available literature but also on the author’s personal experience. The author shows that under the monopoly of this South African company in the field of diamond sales, Soviet organizations, even in the conditions of a South African boycott, were forced to deal with its subordinate structures and the attempts to sideline them were in vain. In particular the article analyses the attitude to a controversial agreement signed by the Soviet state-owned “Glavalmalmazzoloto” and De Beers Centenary in 1990, when, like in many other cases in the “Gorbachev’s era” Moscow’s principle stand was eroded for short-term results even personal gains. The author comes to the conclusion that the responsibility for Moscow’s dealings with De Beers must be borne not by our country, but above all by the United Kingdom, which allowed De Beers have the headquarters of its Central Selling Organisation (CСO) in London.

Molecular characterization of SARS-CoV-2

2020 ◽  
Vol 20 ◽  
Author(s):  
Miribane Dërmaku-Sopjani ◽  
Mentor Sopjani
Keyword(s):  
Public Health ◽  
Drug Targets ◽  
Virus Genome ◽  
Health Crisis ◽  
Public Health Crisis ◽  
Therapeutic Drugs ◽  
New Public Health ◽  
New Public ◽  
And Function

Abstract:: The coronavirus disease 2019 (COVID-19) is currently a new public health crisis threatening the world. This pandemic disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus has been reported to be originated in bats and by yet unknown intermediary animals were transmitted to humans in China 2019. The SARSCoV- 2 spreads faster than its two ancestors the SARS-CoV and Middle East respiratory syndrome coronavirus (MERSCoV) but has reduced fatality. At present, the SARS-CoV-2 has caused about a 1.16 million of deaths with more than 43.4 million confirmed cases worldwide, resulting in a serious threat to public health globally with yet uncertain impact. The disease is transmitted by inhalation or direct contact with an infected person. The incubation period ranges from 1 to 14 days. COVID-19 is accompanied by various symptoms, including cough, fatigue. In most people the disease is mild, but in some other people, such as in elderly and people with chronic diseases, it may progress from pneumonia to a multi-organ dysfunction. Many people are reported asymptomatic. The virus genome is sequenced, but new variants are reported. Numerous biochemical aspects of its structure and function are revealed. To date, no clinically approved vaccines and/or specific therapeutic drugs are available to prevent or treat the COVID-19. However, there are reported intensive researches on the SARSCoV- 2 to potentially identify vaccines and/or drug targets, which may help to overcome the disease. In this review, we discuss recent advances in understanding the molecular structure of SARS-CoV-2 and its biochemical characteristics.

scholarly journals Women’s voices on social media: the advent of feminist epidemiology?

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Céline Miani ◽  
Yudit Namer
Keyword(s):  
Social Media ◽  
Third Space ◽  
Peer Groups ◽  
Research Priorities ◽  
Research Process ◽  
Power Dynamics ◽  
Women's Voices ◽  
New Public Health ◽  
New Public ◽  
On Line

Abstract Background Social media have in recent years challenged the way in which research questions are formulated in epidemiology and medicine, and in particular when it comes to women’s health. They have contributed to the emergence of ‘new’ public health topics (e.g. gynaecological and obstetric violence, long-Covid), the unearthing of testimonials of medical injustice, and in some cases, the creation of new evidence and changes in medical practice. Main text From a theoretical and methodological perspective, we observe two powerful mechanisms at play on social media, which can facilitate the implementation of feminist epidemiological research and address so-called anti-feminist bias: social media as a ‘third’ space and the power of groups. Social media posts can be seen as inhabiting a third space, akin to what is said off the record or in-between doors, at the end of a therapy session. Researchers somehow miss the opportunity to use the third spaces that people occupy. Similarly, another existing space that researchers are seldom interested in are peer-groups. Peer-groups are the ideal terrain to generate bottom-up research priorities. To some extent, their on-line versions provide a safe and emancipatory space, accessible, transnational, and inclusive. We would argue that this could bring feminist epidemiology to scale. Conclusion Given the emancipatory power of social media, we propose recommendations and practical implications for leveraging the potential of online-sourced feminist epidemiology at different stages of the research process (from design to dissemination), and for increasing synergies between researchers and the community. We emphasise that attention should be paid to patriarchal sociocultural contexts and power dynamics, the mitigation of risks for political recuperation and stigmatisation, and the co-production of respectful discourse on studied populations.

scholarly journals A Comparative Discussion of the Judicial Disqualification of Directors under the South African Companies Act

2020 ◽  
pp. 1-24
Author(s):  
Rehana Cassim
Keyword(s):  
United States ◽  
United Kingdom ◽  
South African ◽  
United States Of America ◽  
The United States ◽  
The South ◽  
The United Kingdom ◽  
Locus Standi

Abstract Section 162 of the South African Companies Act 71 of 2008 empowers courts to declare directors delinquent and hence to disqualify them from office. This article compares the judicial disqualification of directors under this section with the equivalent provisions in the United Kingdom, Australia and the United States of America, which have all influenced the South African act. The article compares the classes of persons who have locus standi to apply to court to disqualify a director from holding office, as well as the grounds for the judicial disqualification of a director, the duration of the disqualification, the application of a prescription period and the discretion conferred on courts to disqualify directors from office. It contends that, in empowering courts to disqualify directors from holding office, section 162 of the South African Companies Act goes too far in certain respects.

scholarly journals SARS-CoV-2 testing and sequencing for international arrivals reveals significant cross border transmission of high risk variants into the United Kingdom

2021 ◽  
pp. 101021
Author(s):  
Gareth H Williams ◽  
Alexander Llewelyn ◽  
Ruben Brandao ◽  
Kaiya Chowdhary ◽  
Keeda-Marie Hardisty ◽  
...  
Keyword(s):  
United Kingdom ◽  
High Risk ◽  
Cross Border ◽  
The United Kingdom ◽  
Risk Variants
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