scholarly journals L-Thyroxine improves vestibular compensation in a rat model of acute peripheral vestibulopathy

2021 ◽  
Author(s):  
Guillaume Rastoldo ◽  
Emna Marouane ◽  
Nada El Mahmoudi ◽  
David Pericat ◽  
Isabelle Watabe ◽  
...  
Keyword(s):  
Rat Model ◽  
Hormone Receptors ◽  
Immunohistochemical Analysis ◽  
Vestibular Nuclei ◽  
Vestibular Compensation ◽  
Metabolic Effects ◽  
Iodothyronine Deiodinase ◽  
Vestibular Neurectomy ◽  
Peripheral Vestibulopathy ◽  
Unilateral Vestibular Neurectomy

AbstractUnilateral vestibular lesions induce a vestibular syndrome, which recovers over time due to vestibular compensation. The therapeutic effect of L-Thyroxine (L-T4) on vestibular compensation was investigated by behavioral testing and immunohistochemical analysis in a rat model of unilateral vestibular neurectomy (UVN). We demonstrated that an acute L-T4 treatment reduced the vestibular syndrome and significantly promoted vestibular compensation. Thyroid hormone receptors (TRα and TRβ) and type II iodothyronine deiodinase (DIO2) were present in the vestibular nuclei (VN), supporting a local action of L-T4. We confirmed the T4-induced metabolic effects by demonstrating an increase in the number of cytochrome oxidase-labelled neurons in the VN three days after the lesion. L-T4 treatment modulated glial reaction by decreasing both microglia and oligodendrocytes in the deafferented VN three days after UVN and increased cell proliferation. The survival of newly generated cells was not affected, but neuronal differentiation was altered by the L-T4 treatment.

scholarly journals Sensorimotor Rehabilitation Promotes Vestibular Compensation in a Rodent Model of Acute Peripheral Vestibulopathy by Promoting Microgliogenesis in the Deafferented Vestibular Nuclei

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3377
Author(s):  
Emna Marouane ◽  
Nada El Mahmoudi ◽  
Guillaume Rastoldo ◽  
David Péricat ◽  
Isabelle Watabe ◽  
...  
Keyword(s):  
Vestibular Nucleus ◽  
Vestibular Nuclei ◽  
Original Data ◽  
Vestibular Rehabilitation ◽  
Cellular Level ◽  
Vestibular Compensation ◽  
Medial Vestibular Nucleus ◽  
Vestibular Neurectomy ◽  
Peripheral Vestibulopathy ◽  
The Impact

Acute peripheral vestibulopathy leads to a cascade of symptoms involving balance and gait disorders that are particularly disabling for vestibular patients. Vestibular rehabilitation protocols have proven to be effective in improving vestibular compensation in clinical practice. Yet, the underlying neurobiological correlates remain unknown. The aim of this study was to highlight the behavioural and cellular consequences of a vestibular rehabilitation protocol adapted to a rat model of unilateral vestibular neurectomy. We developed a progressive sensory-motor rehabilitation task, and the behavioural consequences were quantified using a weight-distribution device. This analysis method provides a precise and ecological analysis of posturolocomotor vestibular deficits. At the cellular level, we focused on the analysis of plasticity mechanisms expressed in the vestibular nuclei. The results obtained show that vestibular rehabilitation induces a faster recovery of posturolocomotor deficits during vestibular compensation associated with a decrease in neurogenesis and an increase in microgliogenesis in the deafferented medial vestibular nucleus. This study reveals for the first time a part of the underlying adaptative neuroplasticity mechanisms of vestibular rehabilitation. These original data incite further investigation of the impact of rehabilitation on animal models of vestibulopathy. This new line of research should improve the management of vestibular patients.

Adult and endemic neurogenesis in the vestibular nuclei after unilateral vestibular neurectomy

2021 ◽  
Vol 196 ◽  
pp. 101899
Author(s):  
Guillaume Rastoldo ◽  
Nada El Mahmoudi ◽  
Emna Marouane ◽  
David Pericat ◽  
Isabelle Watabe ◽  
...  
Keyword(s):  
Vestibular Nuclei ◽  
Vestibular Neurectomy ◽  
Unilateral Vestibular Neurectomy

New neurons in the vestibular nuclei complex after unilateral vestibular neurectomy in the adult cat

2007 ◽  
Vol 25 (1) ◽  
pp. 47-58 ◽  
Author(s):  
Brahim Tighilet ◽  
Jean Michel Brezun ◽  
Gustave Dit Duflo Sylvie ◽  
Céline Gaubert ◽  
Michel Lacour
Keyword(s):  
Vestibular Nuclei ◽  
Vestibular Neurectomy ◽  
Adult Cat ◽  
Unilateral Vestibular Neurectomy

scholarly journals Breaking a Dogma: Acute Anti-Inflammatory Treatment Alters Both Post-Lesional Functional Recovery and Endogenous Adaptive Plasticity Mechanisms in a Rodent Model of Acute Peripheral Vestibulopathy.

2021 ◽  
Author(s):  
Nada El Mahmoudi ◽  
Guillaume Rastoldo ◽  
Emna Marouane ◽  
David Péricat ◽  
Isabelle Watabe ◽  
...  
Keyword(s):  
Functional Recovery ◽  
Brain Injuries ◽  
Inflammatory Diseases ◽  
Vestibular Nuclei ◽  
Rodent Model ◽  
Adaptive Plasticity ◽  
Vestibular Loss ◽  
Vestibular Neurectomy ◽  
Peripheral Vestibulopathy ◽  
Anti Inflammatory

Abstract Background : Due to their anti-inflammatory action, corticosteroids are the reference treatment for brain injuries and many inflammatory diseases. However, the benefits of acute corticotherapy are now being questioned, particularly in the case of acute peripheral vestibulopathies (APV), characterized by a vestibular syndrome composed of sustained spinning vertigo, spontaneous ocular nystagmus and oscillopsia, perceptual-cognitive, posturo-locomotor, and vegetative disorders. We assessed the effectiveness of acute corticotherapy, and the functional role of acute inflammation observed after sudden unilateral vestibular loss. Methods : We used the rodent model of unilateral vestibular neurectomy, mimicking the syndrome observed in patients with APV. We treated the animals during the acute phase of the vestibular syndrome, either with placebo or methylprednisolone, an anti-inflammatory corticosteroid. We used both cellular and behavioral approaches with 2-way ANOVA statistical analysis to evaluate the consequences of an acute anti-inflammatory treatment on post-lesional plasticity and functional recovery. Results : We show here, for the first time, that acute anti-inflammatory treatment alters the expression of the adaptive plasticity mechanisms in the deafferented vestibular nuclei and generates enhanced and prolonged vestibular and postural deficits. Conclusions : These results strongly suggest a beneficial role for acute endogenous neuroinflammation in vestibular compensation. They open the way to a change in dogma for the treatment and therapeutic management of vestibular patients.

Diagnostic Pitfalls Related to Morular Metaplasia in Endometrioid Carcinoma: An Underestimated Issue

Pathobiology ◽  
2021 ◽  
pp. 1-6
Author(s):  
Antonio Travaglino ◽  
Antonio Raffone ◽  
Annarita Gencarelli ◽  
Serena Saracinelli ◽  
Fulvio Zullo ◽  
...  
Keyword(s):  
Patient Management ◽  
Hormone Receptors ◽  
Immunohistochemical Analysis ◽  
Endometrioid Carcinoma ◽  
Rectosigmoid Colon ◽  
Solid Carcinoma ◽  
Colorectal Origin ◽  
A Minor ◽  
Diagnostic Pitfalls

Here, we present a case that highlights the crucial pitfalls related to the presence of morular metaplasia (MM) in endometrioid carcinoma, which are insufficiently recognized in the routine pathology practice. A 45-year-old woman underwent hysterectomy with rectosigmoidectomy due to a 11-cm mass involving uterus, right ovary, and rectosigmoid colon. Histologically, the lesion appeared as a predominantly solid carcinoma with a minor glandular component. Results of the first immunohistochemical analysis suggested a colorectal origin (PAX8-, CK7-, WT1-, hormone receptors-, and CDX2+ in the absence of mucinous features). Subsequent immunohistochemistry (nuclear β-catenin+, CD10+, and low ki67 in the solid areas) supported a diagnosis of endometrioid carcinoma with diffuse MM. This case remarks that morphological and immunohistochemical features of MM may conceal the glandular architecture and the typical immunophenotype of endometrioid carcinomas. Acknowledging the diagnostic issues related to MM appears crucial to avoid misdiagnosis and inappropriate patient management.

The human horizontal vestibulo-ocular reflex in response to high-acceleration stimulation before and after unilateral vestibular neurectomy

1990 ◽  
Vol 81 (3) ◽  
pp. 479-490 ◽  
Author(s):  
G. M. Halmagyi ◽  
I. S. Curthoys ◽  
P. D. Cremer ◽  
C. J. Henderson ◽  
M. J. Todd ◽  
...  
Keyword(s):  
Vestibular Neurectomy ◽  
Ocular Reflex ◽  
High Acceleration ◽  
Before And After ◽  
Vestibulo Ocular Reflex ◽  
Unilateral Vestibular Neurectomy

P-81 Metabolic effects of sleeve gastrectomy in a female rat model of diet-induced obesity

2011 ◽  
Vol 7 (3) ◽  
pp. 399-400
Author(s):  
Tatiana Zupekan ◽  
Sandhya Bondada ◽  
Catherine E. Lewis ◽  
Daniel A. DeUgarte
Keyword(s):  
Sleeve Gastrectomy ◽  
Rat Model ◽  
Metabolic Effects ◽  
Female Rat ◽  
Diet Induced Obesity

Neurogenesis and astrogenesis contribution to recovery of vestibular functions in the adult cat following unilateral vestibular neurectomy: cellular and behavioral evidence

Neuroscience ◽  
2009 ◽  
Vol 164 (4) ◽  
pp. 1444-1456 ◽  
Author(s):  
S. Dutheil ◽  
J.M. Brezun ◽  
J. Leonard ◽  
M. Lacour ◽  
B. Tighilet
Keyword(s):  
Vestibular Neurectomy ◽  
Behavioral Evidence ◽  
Adult Cat ◽  
Unilateral Vestibular Neurectomy

scholarly journals Metabolic effects of duodenojejunal bypass surgery in a rat model of type 1 diabetes

2020 ◽  
Author(s):  
Roman Vangoitsenhoven ◽  
Rickesha Wilson ◽  
Gautam Sharma ◽  
Suriya Punchai ◽  
Ricard Corcelles ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Rat Model ◽  
Bypass Surgery ◽  
Metabolic Effects ◽  
Duodenojejunal Bypass

scholarly journals Multiagonist Unimolecular Peptides for Obesity and Type 2 Diabetes: Current Advances and Future Directions

2020 ◽  
Vol 13 ◽  
pp. 117955142090584 ◽  
Author(s):  
Annie Hasib
Keyword(s):  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Hormone Receptors ◽  
Gut Hormones ◽  
Metabolic Effects ◽  
Therapeutic Approaches ◽  
Obesity And Diabetes ◽  
Gut Hormone ◽  
Prevalence Of Obesity

The ever-increasing prevalence of obesity and Type 2 diabetes has necessitated the development of newer and more effective approaches for achieving efficient glycemic control and weight loss. Conventional treatment methods often result in weight gain, further deteriorating the already impaired metabolic control in people with obesity/Type 2 diabetes. Alleviation of obesity and diabetes achieved after bariatric surgeries highlight the therapeutic importance of gut-brain axis and entails development of more patient-friendly approaches replicating the positive metabolic effects of bariatric surgery. Given the potential involvement of several gut hormones in the success of bariatric surgery, the therapeutic importance of synergistic interaction between these hormones for improved metabolism cannot be ignored. Many unimolecular multiagonist peptides are in preclinical and clinical trials as they maximize the combinatorial metabolic efficacy by concurrent activation of multiple gut hormone receptors. This review summarizes the ongoing developments of multiagonist peptides as novel therapeutic approaches against obesity-diabetes.

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