scholarly journals Feedback-related potentials and oscillations during trial and error learning in Parkinson's disease

2021 ◽  
Author(s):  
Laura Vinales ◽  
Rene Quilodran ◽  
Emmanuel Procyk
Keyword(s):  
Parkinson Disease ◽  
Positive Feedback ◽  
Performance Monitoring ◽  
Neurological Diseases ◽  
Learning Task ◽  
Trial And Error ◽  
Time Frequency ◽  
Oscillatory Dynamics ◽  
Related Potentials ◽  
Error Learning

Electrophysiological markers of performance monitoring are thought to reflect functioning of dedicated neural networks and neuromodulatory systems. Whether and how these markers are altered in neurological diseases and whether they can reflect particular cognitive deficits remains to be confirmed. Here we first tested whether the frontal medial feedback-related potential, evoked during a trial and error learning task, is changed in early Parkinson disease patients compared to control subjects. The potential was not changed in amplitude and discriminated negative and positive feedback as in controls. Feedback-related markers in Parkinsons patients also appeared in time-frequency analyses, unaltered in theta (3-7 Hz) band but reduced in beta (20-30 Hz) oscillations for positive feedback. Beta oscillations power appeared to be dramatically globally reduced during the task. Overall, our results show that Beta oscillation markers of performance monitoring captured by EEG are selectively altered in Parkinson disease patients, and that they are accompanied by changes in task-related oscillatory dynamics.

People Newly in Love are More Responsive to Positive Feedback

2012 ◽  
Vol 110 (3) ◽  
pp. 753-763 ◽  
Author(s):  
Cassandra L. Brown ◽  
Richard J. Beninger
Keyword(s):  
Positive Feedback ◽  
Positive Outcomes ◽  
Trial And Error ◽  
Passionate Love ◽  
Reward Seeking ◽  
Learning Tasks ◽  
Error Learning ◽  
Increased Activity ◽  
The Brain

Passionate love is associated with increased activity in dopamine-rich regions of the brain. Increased dopamine in these regions is associated with a greater tendency to learn from reward in trial-and-error learning tasks. This study examined the prediction that individuals who were newly in love would be better at responding to reward (positive feedback). In test trials, people who were newly in love selected positive outcomes significantly more often than their single (not in love) counterparts but were no better at the task overall. This suggests that people who are newly in love show a bias toward responding to positive feedback, which may reflect a general bias towards reward-seeking.

From Positivity to Negativity Bias: Ambiguity Affects the Neurophysiological Signatures of Feedback Processing

2016 ◽  
Vol 28 (4) ◽  
pp. 542-557 ◽  
Author(s):  
Henning Gibbons ◽  
Robert Schnuerch ◽  
Jutta Stahl
Keyword(s):  
Negative Feedback ◽  
Positive Feedback ◽  
Learning Task ◽  
Negativity Bias ◽  
Feedback Processing ◽  
Reward Positivity ◽  
Controlled Attention ◽  
Error Learning ◽  
Late Positive Complex ◽  
Positive Complex

Previous studies on the neurophysiological underpinnings of feedback processing almost exclusively used low-ambiguity feedback, which does not fully address the diversity of situations in everyday life. We therefore used a pseudo trial-and-error learning task to investigate ERPs of low- versus high-ambiguity feedback. Twenty-eight participants tried to deduce the rule governing visual feedback to their button presses in response to visual stimuli. In the blocked condition, the same two feedback words were presented across several consecutive trials, whereas in the random condition feedback was randomly drawn on each trial from sets of five positive and five negative words. The feedback-related negativity (FRN-D), a frontocentral ERP difference between negative and positive feedback, was significantly larger in the blocked condition, whereas the centroparietal late positive complex indicating controlled attention was enhanced for negative feedback irrespective of condition. Moreover, FRN-D in the blocked condition was due to increased reward positivity (Rew-P) for positive feedback, rather than increased (raw) FRN for negative feedback. Our findings strongly support recent lines of evidence that the FRN-D, one of the most widely studied signatures of reinforcement learning in the human brain, critically depends on feedback discriminability and is primarily driven by the Rew-P. A novel finding concerned larger frontocentral P2 for negative feedback in the random but not the blocked condition. Although Rew-P points to a positivity bias in feedback processing under conditions of low feedback ambiguity, P2 suggests a specific adaptation of information processing in case of highly ambiguous feedback, involving an early negativity bias. Generalizability of the P2 findings was demonstrated in a second experiment using explicit valence categorization of highly emotional positive and negative adjectives.

Flanker-Task in Children

2009 ◽  
Vol 23 (4) ◽  
pp. 183-190 ◽  
Author(s):  
Björn Albrecht ◽  
Hartmut Heinrich ◽  
Daniel Brandeis ◽  
Henrik Uebel ◽  
Juliana Yordanova ◽  
...  
Keyword(s):  
Performance Monitoring ◽  
Flanker Task ◽  
Reaction Times ◽  
Event Related Potentials ◽  
Error Rates ◽  
Task Demands ◽  
Button Press ◽  
Multiple Systems ◽  
Time Frequency ◽  
Related Potentials

Response processing may comprise multiple systems working in parallel at different functional levels of performance monitoring. In time-frequency decompositions of response-locked event-related potentials from adults, a subprocess operating in the delta frequency band was interpreted as an index of cognitive error monitoring, distinguishable from a process with theta frequency probably related to motor control. However, it remains unclear whether such subprocesses can also be distinguished in children. In the current study, error processing was assessed in 22 normal boys aged 8 to 15 years using an Erikson Flanker task. Performance data revealed the expected indices of conflicting task demands, such as increased reaction times and error rates. A clear error-negativity was found in the response-locked event-related potentials after incompatible stimuli, and correct responses show a slow negative deflection immediately preceding the button-press, which is absent in errors. Time-frequency decompositions disclosed that a subprocess in the lower delta band preceding correct responses may reflect a more general action monitoring process sensitive to conflicting task demands that, moreover, may prevent one from making an error if it is active early enough. Processes in the delta and theta bands are modulated specifically by errors and may index motor-related monitoring in children. Moreover, these processes occurred considerably earlier for correct responses compared to errors, suggesting that their timing reflects some performance capacity. These considerations may help to clarify response processing in tasks with conflicting demands.

scholarly journals Deterministic response strategies in a trial-and-error learning task

2018 ◽  
Vol 14 (11) ◽  
pp. e1006621 ◽  
Author(s):  
Holger Mohr ◽  
Katharina Zwosta ◽  
Dimitrije Markovic ◽  
Sebastian Bitzer ◽  
Uta Wolfensteller ◽  
...  
Keyword(s):  
Learning Task ◽  
Trial And Error ◽  
Response Strategies ◽  
Error Learning

scholarly journals The neural correlates of reward-related trial-and-error learning: An fMRI study with a probabilistic learning task

2008 ◽  
Vol 15 (10) ◽  
pp. 728-732 ◽  
Author(s):  
K. Koch ◽  
C. Schachtzabel ◽  
G. Wagner ◽  
J. R. Reichenbach ◽  
H. Sauer ◽  
...  
Keyword(s):  
Learning Task ◽  
Neural Correlates ◽  
Trial And Error ◽  
Probabilistic Learning ◽  
Fmri Study ◽  
Error Learning

scholarly journals The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
James M. Brimson ◽  
Sirikalaya Brimson ◽  
Mani Iyer Prasanth ◽  
Premrutai Thitilertdecha ◽  
Dicson Sheeja Malar ◽  
...  
Keyword(s):  
Plant Extracts ◽  
Neurological Diseases ◽  
Digit Span ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Verbal Learning ◽  
Memory Loss ◽  
Learning Task ◽  
Inspection Time ◽  
Neuroprotective Effects

AbstractBacopamonnieri (Linn.) Wettst. has been used in traditional medicine as a drug to enhance and improve memory. In this regard, this study aims to provide B. monnieri's efficacy as a neuroprotective drug and as a nootropic against various neurological diseases. Literatures were collected, following Prisma guidelines, from databases, including Scopus, PubMed, Google Scholar, and Science Direct and were scrutinized using a quality scoring system. Means, standard deviations and ‘n’ numbers were extracted from the metrics and analyzed. Jamovi computer software for Mac was used to carry out the meta-analysis. The selected studies suggested that the plant extracts were able to show some improvements in healthy subjects which were determined in Auditory Verbal Learning Task, digit span-reverse test, inspection time task and working memory, even though it was not significant, as no two studies found statistically significant changes in the same two tests. B. monnieri was able to express modest improvements in subjects with memory loss, wherein only a few of the neuropsychological tests showed statistical significance. B. monnieri in a cocktail with other plant extracts were able to significantly reduce the effects of Alzheimer’s disease, and depression which cannot be solely credited as the effect of B. monnieri. Although in one study B. monnieri was able to potentiate the beneficial effects of citalopram; on the whole, currently, there are only limited studies to establish the memory-enhancing and neuroprotective effects of B. monnieri. More studies have to be done in the future by comparing the effect with standard drugs, in order to establish these effects clinically in the plant and corroborate the preclinical data.

scholarly journals Developing a Sense of Knowing and Acquiring the Skills to Manage Pain in Children with Profound Cognitive Impairments: Mothers’ Perspectives

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Bernie Carter ◽  
Janine Arnott ◽  
Joan Simons ◽  
Lucy Bray
Keyword(s):  
Mixed Method ◽  
Qualitative Data ◽  
Reflective Learning ◽  
Descriptive Statistics ◽  
Mixed Method Study ◽  
Trial And Error ◽  
Knowledge And Skills ◽  
Pain Diary ◽  
Heterogenous Group ◽  
Error Learning

Children with profound cognitive impairment (PCI) are a heterogenous group who often experience frequent and persistent pain. Those people closest to the child are key to assessing their pain. This mixed method study aimed to explore how parents acquire knowledge and skills in assessing and managing their child’s pain. Eight mothers completed a weekly pain diary and were interviewed at weeks 1 and 8. Qualitative data were analysed using thematic analysis and the quantitative data using descriptive statistics. Mothers talked of learning through a system of trial and error (“learning to get on with it”); this was accomplished through “learning to know without a rule book or guide”; “learning to be a convincing advocate”; and “learning to endure and to get things right.” Experiential and reflective learning was evident in the way the mothers developed a “sense of knowing” their child’s pain. They drew on embodied knowledge of how their child usually expressed and responded to pain to help make pain-related decisions. Health professionals need to support mothers/parents to develop their knowledge and skills and to gain confidence in pain assessment and they should recognise and act on the mothers’ concerns.

Brain Responses to World Knowledge Violations: A Comparison of Stimulus- and Fixation-triggered Event-related Potentials and Neural Oscillations

2015 ◽  
Vol 27 (5) ◽  
pp. 1017-1028 ◽  
Author(s):  
Paul Metzner ◽  
Titus von der Malsburg ◽  
Shravan Vasishth ◽  
Frank Rösler
Keyword(s):  
Word Meaning ◽  
Event Related Potentials ◽  
Visual Presentation ◽  
World Knowledge ◽  
N400 Effect ◽  
Brain Potentials ◽  
Time Frequency ◽  
Gamma Range ◽  
Brain Responses ◽  
Related Potentials

Recent research has shown that brain potentials time-locked to fixations in natural reading can be similar to brain potentials recorded during rapid serial visual presentation (RSVP). We attempted two replications of Hagoort, Hald, Bastiaansen, and Petersson [Hagoort, P., Hald, L., Bastiaansen, M., & Petersson, K. M. Integration of word meaning and world knowledge in language comprehension. Science, 304, 438–441, 2004] to determine whether this correspondence also holds for oscillatory brain responses. Hagoort et al. reported an N400 effect and synchronization in the theta and gamma range following world knowledge violations. Our first experiment (n = 32) used RSVP and replicated both the N400 effect in the ERPs and the power increase in the theta range in the time–frequency domain. In the second experiment (n = 49), participants read the same materials freely while their eye movements and their EEG were monitored. First fixation durations, gaze durations, and regression rates were increased, and the ERP showed an N400 effect. An analysis of time–frequency representations showed synchronization in the delta range (1–3 Hz) and desynchronization in the upper alpha range (11–13 Hz) but no theta or gamma effects. The results suggest that oscillatory EEG changes elicited by world knowledge violations are different in natural reading and RSVP. This may reflect differences in how representations are constructed and retrieved from memory in the two presentation modes.

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