scholarly journals Increased intestinal permeability in an orally-reactive peanut allergy model identifies Angiopoietin like-4 as a biomarker

2021 ◽  
Author(s):  
Erin C Steinbach ◽  
Johanna M Smeekens ◽  
Satyaki Roy ◽  
Takahiko Toyonaga ◽  
Caleb Cornaby ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Peanut Allergy ◽  
Pediatric Patients ◽  
Unique Feature ◽  
Intragastric Administration ◽  
Intestinal Epithelial ◽  
Barrier Permeability ◽  
Ara H 2 ◽  
Reaction Severity ◽  
Peanut Proteins

Peanut allergy reaction severity correlates with increased intestinal epithelial cell (IEC) barrier permeability. CC027/GeniUnc mice develop peanut allergy by intragastric administration of peanut proteins without adjuvant. We report that peanut-allergic CC027/GeniUnc mice showed increased IEC barrier permeability and systemic peanut allergen Ara h 2 after challenge. Jejunal epithelial cell transcriptomics showed effects of peanut allergy on IEC proliferation, survival, and metabolism, and revealed IEC-predominant angiopoietin like-4 (Angptl4) as a unique feature of CC027/GeniUnc peanut allergy. CC027/GeniUnc mice and peanut-allergic pediatric patients demonstrated significantly higher serum Angptl4 and ANGPTL4 compared to control C3H/HeJ mice and non-peanut-allergic but atopic patients, respectively, highlighting its potential as a biomarker of peanut allergy.

Ara h 2 and Ara h 6 sensitization predicts peanut allergy in Mediterranean pediatric patients

2014 ◽  
Vol 25 (7) ◽  
pp. 662-667 ◽  
Author(s):  
Chantal Agabriel ◽  
Ouafeh Ghazouani ◽  
Joëlle Birnbaum ◽  
Valérie Liabeuf ◽  
Françoise Porri ◽  
...  
Keyword(s):  
Peanut Allergy ◽  
Pediatric Patients ◽  
Ara H 2 ◽  
Ara H 6

scholarly journals A phase 1 study of heat/phenol-killed,E. coli-encapsulated, recombinant modified peanut proteins Ara h 1, Ara h 2, and Ara h 3 (EMP-123) for the treatment of peanut allergy

Allergy ◽  
2013 ◽  
Vol 68 (6) ◽  
pp. 803-808 ◽  
Author(s):  
R. A. Wood ◽  
S. H. Sicherer ◽  
A. W. Burks ◽  
A. Grishin ◽  
A. K. Henning ◽  
...  
Keyword(s):  
Peanut Allergy ◽  
Phase 1 ◽  
Phase 1 Study ◽  
Ara H 2 ◽  
E Coli ◽  
Ara H 1 ◽  
Ara H 3 ◽  
Peanut Proteins

scholarly journals Diagnostic accuracy of Ara h 2 for detecting peanut allergy in children

2021 ◽  
Author(s):  
Hannah M. Kansen ◽  
Francine C. van Erp ◽  
Yolanda Meijer ◽  
Dianne M.W. Gorissen ◽  
Marike Stadermann ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Peanut Allergy ◽  
Ara H 2
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