scholarly journals Cue-Induced Craving and Negative Emotion Disrupt Response Inhibition in Methamphetamine Use Disorder: Behavioral and fMRI Results from a Mixed Go/No-Go Task

2021 ◽  
Author(s):  
Amirhossein Dakhili ◽  
Arshiya Sangchooli ◽  
Sara Jafakesh ◽  
Mehran Zare-Bidoky ◽  
Ghazaleh Soleimani ◽  
...  
Keyword(s):  
Response Inhibition ◽  
Biomarker Discovery ◽  
Negative Emotion ◽  
Cue Reactivity ◽  
Reaction Times ◽  
Anterior Cingulate ◽  
Addictive Disorders ◽  
Methamphetamine Use ◽  
Methamphetamine Use Disorder ◽  
Drug Cue

Background: Drug-related cue-reactivity, dysfunctional negative emotion processing, and response-disinhibition constitute three core aspects of methamphetamine use disorder (MUD). These phenomena have been studied independently, but the neuroscientific literature on their interaction in addictive disorders remains scant. Methods: fMRI data were collected from 62 individuals with MUD when responding to the geometric Go or No-Go cues superimposed over blank, neutral, negative-emotional and drug-related background images. Neural correlates of drug and negative-emotional cue-reactivity, response-inhibition, and response-inhibition during drug and negative-emotional blocks were estimated, and methamphetamine cue-reactivity was compared between MUDs and 23 healthy controls (HCs). Relationships between clinical and behavioral characteristics and observed activations were subsequently investigated. Results: MUDs had longer reaction times and more errors in drug and negative-emotional blocks compared to neutral and blank ones. MUDs showed higher drug cue-reactivity than HCs across prefrontal regions, fusiform gyrus, and visual cortices (Z>3.1, p-corrected<0.05). Response-inhibition was associated with activations in the precuneus, inferior parietal lobule, and anterior cingulate, temporal and inferior frontal gyri (Z>3.1, p-corrected<0.05). Response-inhibition in drug cue blocks coincided with higher activations in the visual cortex and lower activations in the paracentral lobule and superior and inferior frontal gyri, while inhibition during negative-emotional blocks led to higher superior parietal, fusiform, and lateral occipital activations (Z>3.1, p-corrected<0.05). Conclusion: Higher visual cortical activations and lower parietal and prefrontal activations during drug-related response-inhibition suggest the down-regulation of inhibitory regions and up-regulation of bottom-up drug cue-reactivity. Our results suggest that drug and negative-emotional cue-reactivity influence response-inhibition, and the study of these interactions may aid mechanistic understandings of addiction and biomarker discovery.

scholarly journals Transcranial Direct Current Stimulation to Modulate fMRI Drug Cue Reactivity in Methamphetamine Users: A Randomized Clinical Trial

2021 ◽  
Author(s):  
Hamed Ekhtiari ◽  
Ghazaleh Soleimani ◽  
Rayus Kuplicki ◽  
Hung-Wen Yeh ◽  
Yoon-Hee Cha ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Cue Reactivity ◽  
Methamphetamine Use ◽  
Sham Stimulation ◽  
Group Time ◽  
Methamphetamine Use Disorder ◽  
The Brain ◽  
Drug Cue

Transcranial direct current stimulation (tDCS) has been studied as an adjunctive therapeutic option to alter maladaptive cortical excitability, activity, and connectivity associated with chronic substance use via the application of a weak direct current through the brain. The underlying mechanism of action remains ambiguous, however. We present a randomized, triple-blind, sham-controlled, clinical trial with two parallel arms conducted to determine the neural substrates of tDCS effects on drug craving using an fMRI drug cue reactivity paradigm. Sixty participants with methamphetamine use disorder were randomly assigned to two groups: 30 participants to active tDCS (5x7 cm2, 2 mA, for 20 minutes, anode/cathode over the F4/Fp1 in EEG 10-20 standard system) and 30 participants to the sham group. Neuroimaging data of a methamphetamine cue reactivity (MCR) task were collected immediately before and after stimulation with subjective craving assessed before, after, and during fMRI scans. There was a significant reduction in self-reported craving after stimulation (main effect of time) without any significant effect of group, time, or by group-time interaction. Our whole-brain analysis demonstrated that brain activation decreased in all parts of the brain in the second (post-stimulation) MCR imaging session after sham stimulation (habituation) but this uniform decrease did not occur throughout the brain in the active group. There were significant interactions between the group (active vs. sham) and time (after vs. before stimulation) in five main regions; medial frontal gyrus, anterior insula, inferior parietal lobule, precuneus, and inferior frontal gyrus with higher activations after active stimulation. We simulated computational head models for each individual. There was a significant effect of group in the relationship between level of current in the above-mentioned significant clusters and changes in task-modulated activation. We also found that brain regions with the highest electric fields in the prefrontal cortex showed a significant time by group interaction in task-modulated connectivity (psychophysiological interaction during MCR) in the frontoparietal network. In this two-parallel-arms triple-blind randomized control trial, we did not find any significant effect of the one session of active F4/Fp1 tDCS on drug craving self-report compared to sham stimulation. However, connectivity differences induced by active compared to sham stimulation suggested some potential mechanisms of tDCS to modulate neural response to drug cues among people with methamphetamine use disorder.

scholarly journals Temporally Dynamic Interaction between Drug Cue Reactivity and Response Inhibition: An fMRI Study among People with Methamphetamine Use Disorder

2021 ◽  
Author(s):  
Sara Jafakesh ◽  
Arshiya Sangchooli ◽  
Ardalan Aarabi ◽  
Mohammad Sadegh Helfroush ◽  
Amirhossein Dakhili ◽  
...  
Keyword(s):  
Response Inhibition ◽  
Temporal Dynamics ◽  
Cue Reactivity ◽  
Dynamic Interaction ◽  
Mixed Block ◽  
Drug Cues ◽  
Methamphetamine Use ◽  
Task Duration ◽  
Essential Components ◽  
Methamphetamine Use Disorder

Abstract Cue-induced drug craving and disinhibition are two essential components of continued drug use and relapse in substance use disorders. While these two phenomena develop and interact across time, the temporal dynamics of their underlying neural activity and their interaction remain under-investigated. To explore these dynamics, an analysis of time-varying activation was applied to fMRI data from 62 men with methamphetamine use disorder in their first weeks of recovery in abstinence-based treatment program. Using a mixed block-event, factorial cue-reactivity/Go-NoGo task, and a sliding window across the task duration, dynamically-activated regions were identified in linear mixed effects models (LMEs). Habituation to drug cues across time was observed in the superior temporal gyri, amygdalae, left hippocampus, and right precuneus, while response-inhibition was associated with the sensitization of temporally-dynamic activations across many regions of the inhibitory frontoparietal network. Cue-reactivity and response-inhibition dynamically interact in the parahippocampal gyri and right precuneus (corrected p-value < 0.001) regions, which show a declining cue-reactivity contrast and an increasing response-inhibition contrast. Overall, the declining craving-related activations (habituation) and increasing inhibition-associated activations (sensitization) along the task duration suggest the gradual recruitment of response-inhibition process and the concurrent habituation to drug cues in areas with significant dynamic interaction. This exploratory study demonstrates the time-variance of the neural activations undergirding cue-reactivity, response-inhibition, and their interaction, and suggests potentials to assess this dynamic interaction. This preliminary evidence provides justifications for new avenues in biomarker development and interventions using cue exposure paradigms, which could promote habituation to drug cues and sensitization in inhibitory control regions.

Impulsivity and relapse during treatment of methamphetamine use disorder

2019 ◽  
Vol 65 (4) ◽  
pp. 263-270
Author(s):  
Jana Schultz ◽  
Robert Neumann ◽  
Sabine Steins-Loeber
Keyword(s):  
Response Inhibition ◽  
Individual Characteristics ◽  
Treatment Interventions ◽  
Methamphetamine Use ◽  
Effective Interventions ◽  
Trait Impulsivity ◽  
Healthy Control ◽  
Methamphetamine Use Disorder ◽  
The Impact ◽  
Relapse Rates

Abstract. Aims: The increasing prevalence of patients seeking treatment for methamphetamine use disorder (MUD) in some regions of Germany and the high relapse rates following common treatment interventions make more effective interventions highly needed. The aim of the present study was to enhance our understanding of the impact of impulsivity on relapse during treatment and thus to outline possible individual characteristics that make more tailored interventions necessary. Methodology: Forty-two patients with a diagnosis of MUD admitted to inpatient treatment and 21 matched healthy control participants (HC) completed the Barratt Impulsiveness Scale (BIS-11) as a self-reported measure of trait impulsivity and a go/no-go task with methamphetamine-associated and neutral stimuli to assess deficits of response inhibition. Relapse rates of patients during treatment were assessed. Results: Higher impairment of response inhibition, but not trait impulsivity, significantly predicted relapse during treatment. These findings were observed although patients with MUD compared to HC did not differ with regard to deficits of response inhibition. Conclusions: These findings suggest that patients with MUD who show enhanced deficits of response inhibition are more vulnerable to relapse during treatment and need more tailored treatment interventions.

Assessing methamphetamine-Related Cue Reactivity IN People With Methamphetamine Use Disorder Relative TO Controls

2021 ◽  
pp. 107075
Author(s):  
Alexandre A. Guerin ◽  
Katherine D. Drummond ◽  
Yvonne Bonomo ◽  
Andrew J. Lawrence ◽  
Susan L. Rossell ◽  
...  
Keyword(s):  
Cue Reactivity ◽  
Methamphetamine Use ◽  
Methamphetamine Use Disorder

scholarly journals Temporal Dynamics of the Neural Response to Drug Cues: An fMRI Study among Methamphetamine Users

2021 ◽  
pp. 1-31
Author(s):  
Mohamad B. Soleymani ◽  
◽  
Arshiya Sangchooli ◽  
Mitra Ebrahimpoor ◽  
Mohamad A. Najafi ◽  
...  
Keyword(s):  
Dynamic Analysis ◽  
Static Analysis ◽  
Temporal Dynamics ◽  
Cue Reactivity ◽  
A Priori ◽  
Anterior Cingulate ◽  
Dorsal Anterior Cingulate Cortex ◽  
Activation Patterns ◽  
Addictive Disorders ◽  
Post Hoc

Objective: Cue-induced craving is central to addictive disorders. Most cue-reactivity fMRI studies are analysed statically and report averaged signals, disregarding the dynamic nature of craving and task fatigue. Methods: Thirty-two early abstinent methamphetamine users underwent fMRI-scanning while viewing visual methamphetamine cues. A Craving>Neutral contrast was obtained in regions of interest. To explore changes over time, the pre-processed signal was divided into three intervals. Contrast estimates were calculated within each interval, and were compared using ANOVA followed by post hoc t-tests. The results were compared with those from a static analysis across all blocks. Results: A priori expected activations in the prefrontal cortex, insula and striatum not detected by static analysis were discovered by the dynamic analysis. Post hoc tests revealed distinct temporal activation patterns in several regions. Most showed rapid activation (including both ventral/dorsal striata and most regions in the prefrontal, insular and cingulate cortices) whereas some had delayed activation (the right anterior insula, left middle frontal gyrus, and left dorsal anterior cingulate cortex). Conclusions: This study provides preliminary insights into the temporal dynamicity of cue-reactivity, and the potential of a conventional blocked-design task to consider it using a simple dynamic analysis. We highlight regional activations that were only uncovered by a dynamic analysis, and discuss the interesting and theoretically expected early versus late regional activation patterns. Rapidly activated regions are mostly those involved in the earlier stages of cue-reactivity, while regions with later activation participate in cognitive functions relevant later, such as reappraisal, interoception and executive control.

scholarly journals 639 Co-occuring opioid and methamphetamine use disorder and severe maternal morbidity and mortality in Utah

2021 ◽  
Vol 224 (2) ◽  
pp. S401-S402
Author(s):  
Marcela Smid ◽  
Amanda A. Allshouse ◽  
Kristine Campbell ◽  
Michelle P. Debbink ◽  
Adam G. Gordon ◽  
...  
Keyword(s):  
Maternal Morbidity ◽  
Morbidity And Mortality ◽  
Severe Maternal Morbidity ◽  
Methamphetamine Use ◽  
Maternal Morbidity And Mortality ◽  
Methamphetamine Use Disorder

scholarly journals Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Akhil Sharma ◽  
Arman Harutyunyan ◽  
Bernard L. Schneider ◽  
Anna Moszczynska
Keyword(s):  
Neural Substrates ◽  
Genetically Engineered ◽  
Wild Type ◽  
Therapeutic Approaches ◽  
Self Administration ◽  
Methamphetamine Use ◽  
New Therapeutic Approaches ◽  
Extended Access ◽  
High Doses ◽  
Methamphetamine Use Disorder

AbstractThere is no FDA-approved medication for methamphetamine (METH) use disorder. New therapeutic approaches are needed, especially for people who use METH heavily and are at high risk for overdose. This study used genetically engineered rats to evaluate PARKIN as a potential target for METH use disorder. PARKIN knockout, PARKIN-overexpressing, and wild-type young adult male Long Evans rats were trained to self-administer high doses of METH using an extended-access METH self-administration paradigm. Reinforcing/rewarding properties of METH were assessed by quantifying drug-taking behavior and time spent in a METH-paired environment. PARKIN knockout rats self-administered more METH and spent more time in the METH-paired environment than wild-type rats. Wild-type rats overexpressing PARKIN self-administered less METH and spent less time in the METH-paired environment. PARKIN knockout rats overexpressing PARKIN self-administered less METH during the first half of drug self-administration days than PARKIN-deficient rats. The results indicate that rats with PARKIN excess or PARKIN deficit are useful models for studying neural substrates underlying “resilience” or vulnerability to METH use disorder and identify PARKIN as a novel potential drug target to treat heavy use of METH.

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