scholarly journals Association of Egg Consumption, Metabolic Markers, and Risk of Cardiovascular Diseases

2021 ◽  
Author(s):  
Lang Pan ◽  
Lu Chen ◽  
Jun Lv ◽  
Yuanjie Pang ◽  
Yu Guo ◽  
...  
Keyword(s):  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Apolipoprotein A1 ◽  
Plasma Samples ◽  
Cvd Risk ◽  
Metabolic Markers ◽  
Egg Consumption ◽  
Nested Case Control ◽  
Control Study

AbstractObjectiveTo simultaneously explore the associations of self-reported egg consumption with plasma metabolic markers and these markers with CVD risk.MethodsTotally 4,778 participants (3,401 CVD cases subdivided into subtypes and 1,377 controls) aged 30-79 were selected from a nested case-control study based on the China Kadoorie Biobank. Targeted nuclear magnetic resonance was used to quantify 225 metabolites and derived traits in baseline plasma samples. Linear regression was conducted to assess associations between self-reported egg consumption and metabolic markers, which were further compared with associations between metabolic markers and CVD risk.ResultsEgg consumption was associated with 24 out of 225 markers, including positive associations for apolipoprotein A1, acetate, mean HDL diameter, and lipid profiles of very large and large HDL, and inverse associations for total cholesterol and cholesterol esters in small VLDL. Among these 24 markers, 14 of them were associated with CVD risk. In general, the associations of metabolic markers with egg consumption and of metabolic markers with CVD risk showed opposite patterns.ConclusionsIn the Chinese population, egg consumption is associated with several metabolic markers, which may partially explain the protective effect of egg consumption on CVD.

scholarly journals Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study

Biomarkers ◽  
2014 ◽  
Vol 19 (2) ◽  
pp. 159-165 ◽  
Author(s):  
Jun Tsukiji ◽  
Soo Jung Cho ◽  
Ghislaine C. Echevarria ◽  
Sophia Kwon ◽  
Phillip Joseph ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
World Trade ◽  
Case Control Study ◽  
World Trade Center ◽  
Case Control ◽  
Apolipoprotein A1 ◽  
Increased Risk ◽  
Trade Center ◽  
Nested Case Control ◽  
Control Study

scholarly journals Complement C3 gene polymorphisms are associated with lipid levels, but not the risk of coronary artery disease: a case-control study

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Gaojun Cai ◽  
Li Li ◽  
Yifei Chen ◽  
Haomin Huang ◽  
Lei Yu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Apolipoprotein A1 ◽  
Lipid Levels ◽  
Artery Disease ◽  
Control Study

Abstract Background Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Previous studies have shown that complement component 3 (C3) is associated with atherosclerosis and cardiovascular risk factors. Methods We conducted this study to evaluate the associations between tagSNPs in the C3 gene locus and the CAD susceptibility and lipid levels in the Chinese population. A hospital-based case-control study, including 1017 subjects (580 CAD patients and 437 non-CAD controls), was conducted. TagSNPs in the C3 gene were searched and genotyped by using the polymerase chain reaction-ligase detection reaction method. Results The C3 levels were positively associated with the low-density lipoprotein cholesterol (LDL-C) levels (r = 0.269, P = 0.001). Compared with those in controls, the serum C3 levels in CAD patients were significantly higher (Control: 0.94 + 0.14 g/l; CAD: 1.10 + 0.19 g/l, P < 0.001). No significant differences in genotype or allele frequencies were observed between CAD patients and controls. The minor T allele of rs2287848 was associated with low apolipoprotein A1 (ApoA1) levels in controls (Bonferroni corrected P, Pc = 0.032). Linkage disequilibrium and haplotype analysis established two haplotype blocks (Block1: rs344555-rs2277984, Block 2: rs2287848-rs11672613) and six haplotypes. No significant associations between haplotypes and the risk of CAD were observed (all Pc > 0.05). Conclusions The results revealed that C3 gene polymorphisms were associated with the lipid levels, but not CAD susceptibility in the Chinese population.

Sign in / Sign up

Export Citation Format

Share Document