scholarly journals Characterizing the variation in chromosome structure ensembles in the context of the nuclear microenvironment

2021 ◽  
Author(s):  
Priyojit Das ◽  
Tongye Shen ◽  
Rachel Patton McCord
Keyword(s):  
Statistical Analysis ◽  
Chromosome Structure ◽  
Chromosome Region ◽  
Radius Of Gyration ◽  
Physical Interaction ◽  
Imaging Data ◽  
Cell Type ◽  
Epigenetic State ◽  
Analysis Technique ◽  
Statistical Analysis Technique

Inside the nucleus, chromosomes are subjected to direct physical interaction between different components, active forces, and thermal noise, leading to the formation of an ensemble of three-dimensional structures. However, it is still not well understood to what extent and how the structural ensemble varies from one chromosome region or cell-type to another. We designed a statistical analysis technique and applied it to single-cell chromosome imaging data to reveal the fluctuation of individual chromosome structures. By analyzing the resulting structural landscape, we find that the largest dynamic variation is the overall radius of gyration of the chromatin region, followed by domain reorganization within the region. By comparing different human cell-lines and experimental perturbations data using this statistical analysis technique and a network entropy approach, we identify both cell-type and condition-specific features of the structural landscapes. We identify a relationship between epigenetic state and the properties of chromosome structure fluctuation and validate this relationship through polymer simulations. Overall, our study suggests that the types of variation in a chromosome structure ensemble are cell-type as well as region-specific and can be attributed to constraints placed on the structure by factors such as variation in epigenetic state.

scholarly journals STANDARIZATION OF EXPERIENTIAL LEARNING FACILITATOR IN WEST SUMATERA

2018 ◽  
Vol 37 (2) ◽  
Author(s):  
Endang Sepdanius ◽  
Rini Afriani ◽  
Anton Komaini
Keyword(s):  
Statistical Analysis ◽  
Experiential Learning ◽  
Quantitative Method ◽  
National Agency ◽  
Outdoor Activities ◽  
Tourism Sector ◽  
Analysis Technique ◽  
Statistical Analysis Technique ◽  
Two Stages ◽  
Descriptive Statistical Analysis

Abstract: The purpose of this research was to standardize experiential learning (EL) facilitators in outdoor activities in West Sumatera. The result of this research is expected that the EL facilitator is competent with the issuance of professional certificate by the National Agency for Profession Certification (BNSP). This research uses quantitative method with analytic descriptive approachand has been done in two stages. First, Implementation of workshop program for experiential learning facilitators and produce recommendations for workshop participants. Second, conductied a competency test of EL facilitators by the National Agency for Profession Certification (BNSP). The number of respondents was 20 facilitators from 4 providers (n=20). Data were collected using Indonesian national competence standard of tourism sector in the field of outbound / experiential learning facilitator and BNSP test. The data were processed using descriptive statistical analysis technique.  The results of the study showed that 19 participants were declared competent and 1 incompetent participant. The results of the study showed that 19 participants were declared competent and 1 participants declared incompetent by the National Agency for Profession Certification (BNSP). These results indicate that the EL workshop program resulted 19 participants have been declared competent in guiding outdoor activities using experiential learning approach.Keyword: facilitator of experiential learning, standardization, outbound training STANDARISASI PADA FASILITATOR EXPERIENTIAL LEARNING DI SUMATERA BARAT Abstrak: Tujuan penelitian ini adalah melakukan standarisasi pada fasilitator experiential learning (EL) dalam kegiatan outdoor di Sumatera Barat. Hasil penelitian diharapkan dapat memberikan masukan untuk dikeluarkannya sertifikat profesi oleh Badan Nasional Sertifikat Profesi (BNSP) kepada fasilitator EL karena memenuhi syarat kompetensi. Penelitian ini menggunakan metode kuantitatif dengan pendekatan deskriptif analitik dilakukan dalam dua tahap: (1) melaksanaan program workshop bagi fasilitator EL dan memberikan rekomendasi pada peserta, (2) melakukan uji kompetensi fasilitator EL oleh BNSP. Jumlah responden adalah 20 orang fasilitator dari 4 provider (n=20). Data dikumpulkan menggunakan standar kompetensi kerja nasional Indonesia sektor pariwisata bidang kepemanduan outbound/fasilitator experiential learning dan pelaksanaan test profesi oleh BNSP. Data diolah menggunakan teknik analisis statistik deskriptif. Hasil dari penelitian menunjukan bahwa 19 fasilitator dinyatakan lulus dan 1 orang dinyatakan tidak lulus oleh BNSP. Hasil ini menunjukan bahwa program workshop EL menghasilkan 19 peserta yang kompeten dalam memandu kegiatan outdoor menggunakan pendekatan experiential learning. Kata Kunci: fasilitator experiential learning, standarisasi, outbound training

scholarly journals Comparisons of full correlation analysis (FCA) and imaging Doppler interferometry (IDI) winds using the Buckland Park MF radar

2004 ◽  
Vol 22 (11) ◽  
pp. 3829-3842 ◽  
Author(s):  
D. A. Holdsworth ◽  
I. M. Reid
Keyword(s):  
Statistical Analysis ◽  
Correlation Analysis ◽  
Radial Velocity ◽  
Wind Velocity ◽  
Data Set ◽  
Analysis Technique ◽  
Wind Measurements ◽  
Statistical Analysis Technique ◽  
Full Correlation Analysis ◽  
Mf Radar

Abstract. We present results from three years of mesospheric and thermospheric wind measurements obtained using full correlation analysis (FCA) and imaging Doppler interferometry (IDI) for the Buckland Park MF radar. The IDI winds show excellent agreement with the FCA winds, both for short (2-min) and longer term (hourly, fortnightly) comparisons. An extension to a commonly used statistical analysis technique is introduced to show that the IDI winds are approximately 10% larger than the FCA winds, which we attribute to an underestimation of the FCA winds rather than an indication that IDI overestimates the wind velocity. Although the distribution of IDI effective scattering positions are shown to be consistent with volume scatter predictions, the velocity comparisons contradict volume scatter predictions that the IDI velocity will be overestimated. However, reanalysis of a 14-day data set suggests the lack of overestimation is due to the radial velocity threshold used in the analysis, and that removal of this threshold produces the volume scatter predicted overestimation of the IDI velocities. The merits of using hourly IDI estimates versus hourly averaged 2-min IDI estimates are presented, suggesting that hourly estimated turbulent velocities are overestimated.

scholarly journals Gestalt Counseling Effectiveness with Engineering Techniques to Increase Self-Consideration in Learning Process

2017 ◽  
Vol 1 (1) ◽  
pp. 19
Author(s):  
Arief Munandar ◽  
Nyoman Dantes ◽  
Wayan Tirka
Keyword(s):  
Statistical Analysis ◽  
Learning Process ◽  
Sampling Technique ◽  
Self Esteem ◽  
Validity And Reliability ◽  
Significance Level ◽  
Self Confidence ◽  
Analysis Technique ◽  
Statistical Analysis Technique ◽  
Academic Year

Confidence is important to be possessed by students through the learning process, students who have low self-confidence will be less optimal in developing ability. This study aims to determine the effectiveness of gestalt counseling with the technique around to improve confidence in the learning process in students of class XI MIA 4 SMA Negeri 1 Singaraja academic year 2016/2017. This type of research is pre-experimental with one group pretest-posttest design. Samples of research were six students selected through purposive sampling technique. Methods of data collection using a confident questionnaire that has been calculated the validity and reliability. The subjects from the study were students of class XI MIA 4 who had low self-esteem. Data analysis technique used is t-test statistical analysis technique. The results from the analysis, found that gestalt counseling with the technique of traveling can increase confidence. It is concluded from the analysis result, t count> table with significance level 5% (4, 38> 2, 015). The results from the analysis show that the hypothesis proposed in this study is acceptable. As the implication of this research is expected to be an alternative for counseling teachers in schools in improving student self-confidence.

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