scholarly journals Haplotype Analysis of the TRB Locus by TCRB Repertoire Sequencing

2018 ◽  
Author(s):  
Timothy J Looney ◽  
Dzifa Y Duose ◽  
Geoffrey Lowman ◽  
Elizabeth Linch ◽  
Joud Hajjar ◽  
...  
Keyword(s):  
T Cell Receptor ◽  
Haplotype Analysis ◽  
Cell Receptor ◽  
Repetitive Nature ◽  
Repertoire Sequencing ◽  
T Cell Receptor Beta ◽  
Variable Gene ◽  
Beta Variable ◽  
Tcrb Locus ◽  
Receptor Beta

AbstractPolymorphism within the T cell receptor beta variable gene (TRBV) has been implicated in autoimmune disease and immuneCrelated adverse events (IRAEs) during immunotherapy. Previous efforts to evaluate TRBV polymorphism by whole genome sequencing (WGS) have been hampered by the repetitive nature of the TCRB locus. We present a novel longCamplicon TCRB repertoire sequencing approach to evaluate TRBV polymorphism from peripheral blood, which we use to identify TRBV allele haplotypes in 81 Caucasians.

scholarly journals Haplotype Analysis of the T-Cell Receptor Beta (TCRB) Locus by Long-amplicon TCRB Repertoire Sequencing

2019 ◽  
Vol 0 (0) ◽  
pp. 0 ◽  
Author(s):  
TimothyJ Looney ◽  
DzifaY Duose ◽  
Geoffrey Lowman ◽  
Elizabeth Linch ◽  
Joud Hajjar ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Haplotype Analysis ◽  
Cell Receptor ◽  
Repertoire Sequencing ◽  
T Cell Receptor Beta ◽  
Tcrb Locus ◽  
Receptor Beta

Evaluating the link between T cell receptor beta variable gene polymorphism and immune mediated adverse events during checkpoint blockade immunotherapy.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e15002-e15002 ◽  
Author(s):  
Timothy Looney ◽  
Elizabeth Linch ◽  
Geoffrey Lowman ◽  
Lauren Miller ◽  
Jianping Zheng ◽  
...  
Keyword(s):  
T Cell ◽  
Adverse Events ◽  
Gene Polymorphism ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Immune Mediated ◽  
T Cell Receptor Beta ◽  
Variable Gene ◽  
Beta Variable ◽  
Receptor Beta

scholarly journals Effect of Triptolide on T-Cell Receptor Beta Variable Gene mRNA Expression in Rats With Collagen-Induced Arthritis

2012 ◽  
Vol 295 (6) ◽  
pp. 922-927 ◽  
Author(s):  
Jixi Wang ◽  
Aibing Wang ◽  
Heqing Zeng ◽  
Lantao Liu ◽  
Wenhao Jiang ◽  
...  
Keyword(s):  
T Cell ◽  
Mrna Expression ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Collagen Induced Arthritis ◽  
T Cell Receptor Beta ◽  
Variable Gene ◽  
Beta Variable ◽  
Receptor Beta ◽  
Gene Mrna

Narrowing of T‐cell receptor beta variable repertoire during symptomatic herpesvirus infection in transplant patients

2009 ◽  
Vol 88 (2) ◽  
pp. 125-135 ◽  
Author(s):  
Katherine K Wynn ◽  
Tania Crough ◽  
Scott Campbell ◽  
Keith McNeil ◽  
Andrew Galbraith ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Herpesvirus Infection ◽  
Transplant Patients ◽  
T Cell Receptor Beta ◽  
Beta Variable ◽  
Receptor Beta

Expression Profile and Clonality of T-Cell Receptor Beta Variable Genes in Normal Human Endometrium

2006 ◽  
Vol 55 (5) ◽  
pp. 349-359 ◽  
Author(s):  
Pouneh Dokouhaki ◽  
Rosa Moghadam ◽  
Firoozeh Akbariasbagh ◽  
Amirhassan Zarnani ◽  
Marefat Ghaffari Novin ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Expression Profile ◽  
Cell Receptor ◽  
Human Endometrium ◽  
T Cell Receptor Beta ◽  
Normal Human ◽  
Beta Variable ◽  
Receptor Beta ◽  
Variable Genes

The Human T cell Receptor Beta Variable (TRBV) Genes

2000 ◽  
Vol 17 (1) ◽  
pp. 42-54 ◽  
Author(s):  
Géraldine Folch ◽  
Marie-Paule Lefranc
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Human T Cell ◽  
T Cell Receptor Beta ◽  
Beta Variable ◽  
Receptor Beta
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