scholarly journals Incubation of discriminative stimulus-controlled cocaine craving: An animal model relevant to relapse prevention

2018 ◽  
Author(s):  
Rajtarun Madangopal ◽  
Brendan J Tunstall ◽  
Lauren E Komer ◽  
Sophia J Weber ◽  
Jennifer K Hoots ◽  
...  
Keyword(s):  
Relapse Prevention ◽  
Neural Mechanisms ◽  
Drug Addicts ◽  
Preclinical Studies ◽  
Palatable Food ◽  
Cocaine Craving ◽  
Food Seeking ◽  
Over Time ◽  
Time Animal

In abstinent drug addicts, cues formerly associated with drug-taking experiences gain relapse-inducing potency ('incubate') over time. Animal models of incubation may help develop treatments to prevent relapse, but these models have ubiquitously focused on the role of conditioned stimuli (CSs) signaling drug delivery. From a translational perspective this is problematic because people encounter these stimuli only during or after relapse. For this reason, incubation in response to discriminative stimuli (DSs) that signal drug availability before relapse, not yet examined in preclinical studies, could be more relevant to relapse prevention. We trained rats to self-administer cocaine (or palatable food) under DS control, then investigated DS-controlled incubation of craving, in the absence of drug-paired CSs. DS-controlled cocaine (but not palatable food) seeking incubated over 60 days of abstinence and persisted up to 300 days. Understanding the neural mechanisms of this DS-controlled incubation holds significant promise for drug relapse treatments.

scholarly journals Discriminative stimuli are sufficient for incubation of cocaine craving

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Rajtarun Madangopal ◽  
Brendan J Tunstall ◽  
Lauren E Komer ◽  
Sophia J Weber ◽  
Jennifer K Hoots ◽  
...  
Keyword(s):  
Relapse Prevention ◽  
Neural Mechanisms ◽  
Drug Addicts ◽  
Palatable Food ◽  
Discriminative Stimuli ◽  
Cocaine Craving ◽  
Seeking Behavior ◽  
Food Seeking ◽  
Over Time

In abstinent drug addicts, cues formerly associated with drug-taking experiences gain relapse-inducing potency (‘incubate’) over time. Animal models of incubation may help develop treatments to prevent relapse, but these models have ubiquitously focused on the role of conditioned stimuli (CSs) signaling drug delivery. Discriminative stimuli (DSs) are unique in that they exert stimulus-control over both drug taking and drug seeking behavior and are difficult to extinguish. For this reason, incubation of the excitatory effects of DSs that signal drug availability, not yet examined in preclinical studies, could be relevant to relapse prevention. We trained rats to self-administer cocaine (or palatable food) under DS control, then investigated DS-controlled incubation of craving, in the absence of drug-paired CSs. DS-controlled cocaine (but not palatable food) seeking incubated over 60 days of abstinence and persisted up to 300 days. Understanding the neural mechanisms of this DS-controlled incubation holds promise for drug relapse treatments.

scholarly journals The Anxiogenic Drug Yohimbine Reinstates Palatable Food Seeking in a Rat Relapse Model: a Role of CRF1 Receptors

2005 ◽  
Vol 31 (10) ◽  
pp. 2188-2196 ◽  
Author(s):  
Udi E Ghitza ◽  
Sarah M Gray ◽  
David H Epstein ◽  
Kenner C Rice ◽  
Yavin Shaham
Keyword(s):  
Palatable Food ◽  
Food Seeking

Raza, ciencia, sociedad

2015 ◽  
Vol 2 (4) ◽  
Author(s):  
Peter Wade
Keyword(s):  
Cultural Discourse ◽  
Human Biology ◽  
Science And Society ◽  
Race Science ◽  
And Behavior ◽  
Over Time

<p class="p1"><span class="s1"><strong>Resumen </strong></span>| En este trabajo quiero presentar una cronología convencional del concepto raza que marca un movimiento en el cual raza cambia de ser una idea basada en la cultura y el medio ambiente, a ser algo biológico, inflexible y determinante, para luego volver a ser una noción que habla de la cultura<span class="s2"><strong>.</strong></span>Resumo cómo la idea de raza ha cambiado a través del tiempo, mirando necesariamente el rol que ha desempeñado la ciencia, y enfocando los diferentes discursos de índole <em>natural-cultural </em>sobre los cuerpos, el medio ambiente y el comportamiento, en los cuales las dimensiones culturales y naturales siempre coexisten<span class="s2"><strong>.</strong></span>“La naturaleza” no puede ser entendida solamente como “la biología” y ni la naturaleza ni la biología necesariamente implican sólo el determinismo, la fijeza y la inmutabilidad Estar abiertos a la coexistencia de la cultura y la naturaleza y a la mutabilidad de la naturaleza nos permite ver mejor el ámbito de acción del pensamiento racial.</p><p class="p1"><strong><em>Race, Science and Society</em></strong></p><p class="p1"> </p><p class="p2"><span class="s1"><strong>Abstract </strong></span>| In this article I present and critique a standard chronology of race as, first, a concept rooted in culture and environment, and later in human biology and determinism, and finally back to culture alone<span class="s2"><strong><em>.</em></strong></span>I will outline changing understandings of race over time, with some attention to the role of science, broadly understood, and on the continuing but changing character of race as a natural-cultural discourse about organic bodies, environments and behavior, in which both cultural and natural dimensions always co-exist<span class="s2"><strong><em>.</em></strong></span>“Nature” is not to be understood simply as “biology,” and neither nature nor biology necessarily imply the fixity and determination that they are often assumed nowadays to involve<span class="s2"><strong><em>.</em></strong></span>Being open to the co-existence of culture and nature and the mutability of the latter allows us to better comprehend the whole range of action of racial thinking.</p>

Biopsychosocial Patterning of Multimorbidity and Its Consequences

2018 ◽  
pp. 220-236
Author(s):  
Elliot Friedman ◽  
Beth LeBreton ◽  
Lindsay Fuzzell ◽  
Elizabeth Wehrpsann
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Functional Outcomes ◽  
The United States ◽  
Chronic Medical Conditions ◽  
Quality Of Life Research ◽  
Increased Risk ◽  
Over Time

By many estimates the majority of adults over age 65 have two or more chronic medical conditions (multimorbidity) and are consequently at increased risk of adverse functional outcomes. Nonetheless, many older adults with multimorbidity are able to maintain high levels of function and retain good quality of life. Research presented here is designed to understand the influences that help ensure better functional outcomes in these older adults. This chapter presents findings that draw on data from the Midlife in the United States study. The independent and interactive contributions of diverse factors to multimorbidity and changes in multimorbidity over time are reviewed. The degree that multimorbidity increases risk of cognitive impairment and disability is examined. The role of inflammation as a mediator is considered. Multimorbidity is increasingly the norm for older adults, so better understanding of factors contributing to variability in multimorbidity-related outcomes can lead to improved quality of life.

scholarly journals Learning by Doing: The Use of Distance, Corners and Length in Rewarded Geometric Tasks by Zebrafish (Danio rerio)

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 2001
Author(s):  
Greta Baratti ◽  
Angelo Rizzo ◽  
Maria Elena Miletto Petrazzini ◽  
Valeria Anna Sovrano
Keyword(s):  
Danio Rerio ◽  
Three Dimensional ◽  
Reference Memory ◽  
Spatial Abilities ◽  
Learning By Doing ◽  
Surface Distance ◽  
Extended Surfaces ◽  
Unequal Length ◽  
Over Time

Zebrafish spontaneously use distance and directional relationships among three-dimensional extended surfaces to reorient within a rectangular arena. However, they fail to take advantage of either an array of freestanding corners or an array of unequal-length surfaces to search for a no-longer-present goal under a spontaneous cued memory procedure, being unable to use the information supplied by corners and length without some kind of rewarded training. The present study aimed to tease apart the geometric components characterizing a rectangular enclosure under a procedure recruiting the reference memory, thus training zebrafish in fragmented layouts that provided differences in surface distance, corners, and length. Results showed that fish, besides the distance, easily learned to use both corners and length if subjected to a rewarded exit task over time, suggesting that they can represent all the geometrically informative parts of a rectangular arena when consistently exposed to them. Altogether, these findings highlight crucially important issues apropos the employment of different behavioral protocols (spontaneous choice versus training over time) to assess spatial abilities of zebrafish, further paving the way to deepen the role of visual and nonvisual encodings of isolated geometric components in relation to macrostructural boundaries.

scholarly journals Effects of Dysbiosis and Dietary Manipulation on the Digestive Microbiota of a Detritivorous Arthropod

2021 ◽  
Vol 9 (1) ◽  
pp. 148
Author(s):  
Marius Bredon ◽  
Elisabeth Depuydt ◽  
Lucas Brisson ◽  
Laurent Moulin ◽  
Ciriac Charles ◽  
...  
Keyword(s):  
Crucial Role ◽  
Structure And Function ◽  
Ecological Interactions ◽  
Dietary Manipulation ◽  
Biotic Factors ◽  
Abiotic And Biotic Factors ◽  
And Function ◽  
Multicellular Organisms ◽  
Over Time

The crucial role of microbes in the evolution, development, health, and ecological interactions of multicellular organisms is now widely recognized in the holobiont concept. However, the structure and stability of microbiota are highly dependent on abiotic and biotic factors, especially in the gut, which can be colonized by transient bacteria depending on the host’s diet. We studied these impacts by manipulating the digestive microbiota of the detritivore Armadillidium vulgare and analyzing the consequences on its structure and function. Hosts were exposed to initial starvation and then were fed diets that varied the different components of lignocellulose. A total of 72 digestive microbiota were analyzed according to the type of the diet (standard or enriched in cellulose, lignin, or hemicellulose) and the period following dysbiosis. The results showed that microbiota from the hepatopancreas were very stable and resilient, while the most diverse and labile over time were found in the hindgut. Dysbiosis and selective diets may have affected the host fitness by altering the structure of the microbiota and its predicted functions. Overall, these modifications can therefore have effects not only on the holobiont, but also on the “eco-holobiont” conceptualization of macroorganisms.

Sign in / Sign up

Export Citation Format

Share Document