scholarly journals Microstructure of Ingestive Behavior in Mus Musculus

2019 ◽  
Author(s):  
Giorgio Onnis ◽  
Ethel Layco-Bader ◽  
Laurence Tecott
Keyword(s):  
Water Intake ◽  
Ingestive Behavior ◽  
Drinking Patterns ◽  
Behavioral Regulation ◽  
Fine Grained ◽  
Behavioral Organization ◽  
Volume Balance ◽  
Hierarchical Levels ◽  
Food And Water Intake ◽  
Locomotor Behaviors

ABSTRACTWe describe a novel quantitative home cage monitoring (HCM) approach for dissecting spontaneous patterns of ingestive and locomotor behaviors into a hierarchically organized series of behavioral facets or endophenotypes. Fine-grained analyses of a large multimodal 16-strain behavioral dataset collected from 169 mice revealed bouts of feeding, drinking and locomotor behaviors occurring within animals’ Active States. We have automated the detection of these bouts and their discrete properties including bout sizes, rates, durations, and intensities. We have developed a hierarchically organized model of behavioral organization enabling analysis of relationships among Active/Inactive State properties and those of feeding, drinking and locomotor bouts. Robust and analogous patterns of interrelationships among these endophenotypes were found for feeding, drinking behaviors, and these differed markedly from those for locomotor behaviors. For feeding and drinking, patterns of reciprocal relationships were observed for pairs of endophenotypes at multiple hierarchical levels. Moreover, endophenotype variability was highest at lowest hierarchical levels progressively diminished at higher levels, so that variability of gross levels of food and water intake were much less than those of their lower level determinants. By contrast, interrelationships among locomotor endophenotypes differed markedly from those of ingestive behavior. Altogether, these findings raise the possibility that behavioral regulation of food and water intake may make an important contribution to the homeostatic maintenance of energy and volume balance.

Amygdaloid lesions impair ingestive responses to 2-deoxy-D-glucose but not insulin

1982 ◽  
Vol 242 (1) ◽  
pp. R129-R135 ◽  
Author(s):  
M. G. Tordoff ◽  
P. J. Geiselman ◽  
C. V. Grijalva ◽  
S. W. Kiefer ◽  
D. Novin
Keyword(s):  
Food Consumption ◽  
Water Intake ◽  
Ingestive Behavior ◽  
Male Rats ◽  
Feeding Response ◽  
Short Term ◽  
Food And Water Intake ◽  
Bilateral Lesions ◽  
And Control ◽  
Related Increase

Bilateral lesions of the amygdala in male rats impaired the feeding response to 2-deoxy-D-glucose (2-DG; 100, 200, and 400 mg/kg). During the first 3 h postinjection, control rats displayed a dose-related increase in both food and water consumption. Rats with amygdaloid lesions did not respond to 2-DG until the 3rd h postinjection, when only the two largest doses significantly increased food consumption. Their water intake remained unaffected throughout the 3-h postinjection period. During the 4th-24th h post-2-DG administration, both groups displayed a dose-related suppression of food and water intake. Following insulin (10 U/kg), amygdaloid and control animals were indistinguishable: both groups showed a significant short-term increase in food and water intake followed by a reduction in intakes during the 4th-24th h. Central visceral pathways that are important for the ingestive responses to 2-DG may be interrupted by amygdaloid lesions. However, pathways responsible for the ingestive behavior induced by insulin appear unaffected by damage to the amygdala.

Amylin infusion into rat nucleus accumbens potently depresses motor activity and ingestive behavior

2001 ◽  
Vol 281 (4) ◽  
pp. R1232-R1242 ◽  
Author(s):  
Brian A. Baldo ◽  
Ann E. Kelley
Keyword(s):  
Nucleus Accumbens ◽  
Motor Activity ◽  
Water Intake ◽  
Ingestive Behavior ◽  
Behavioral Effects ◽  
Central Administration ◽  
Behavioral Regulation ◽  
Calcitonin Gene ◽  
Rat Nucleus Accumbens ◽  
Motor Effects

Amylin, a calcitonin gene-related peptide-like peptide coreleased with insulin, exerts anorexic effects on central administration. Because previous studies revealed dense amylin binding in the nucleus accumbens (Acb), we investigated the behavioral effects of amylin infusions (10, 30, and 100 ng/side) into Acb subregions. Intra-Acb shell amylin infusions decreased ambulation, rearing, feeding, and drinking in either food-deprived rats or water-deprived rats; motor activity was affected more potently than ingestive behavior. Moreover, intra-Acb shell amylin reduced motor activity in nondeprived rats tested in the absence of food or water, indicating that the expression of amylin's effects is independent of drive or proximal incentives. Intra-Acb core amylin infusions in water-deprived rats also decreased ambulation and water intake, although anterior Acb placements were associated with smaller motor effects, regardless of Acb subregion. In contrast to amylin's effects, intra-Acb shell infusions of orexin-A (50, 100, and 500 ng/side) had no effects on motor activity, feeding, or drinking. Hence the Acb may be a target for behavioral regulation by satiety-related peptides like amylin.

Effect of cerebrocrast on body and organ weights, food and water intake, and urine output of normal rats

2008 ◽  
Vol 26 (8) ◽  
pp. 908-915 ◽  
Author(s):  
Janina Briede ◽  
Mara Stivrina ◽  
Dzintra Stoldere ◽  
Brigita Vigante ◽  
Gunars Duburs
Keyword(s):  
Water Intake ◽  
Urine Output ◽  
Organ Weights ◽  
Food And Water Intake

scholarly journals Involvement of Central β-Adrenergic Circuitry in Food and Water Intake in Chickens

2015 ◽  
Vol 47 (2) ◽  
pp. 128-132 ◽  
Author(s):  
A. Baghbanzadeh ◽  
Z. Hamidiya ◽  
M. H. Geranmayeh
Keyword(s):  
Water Intake ◽  
Food And Water Intake

Acclimation of rats following stepwise or direct exposure to heat

1985 ◽  
Vol 59 (2) ◽  
pp. 408-412 ◽  
Author(s):  
A. R. Gwosdow ◽  
E. L. Besch ◽  
C. L. Chen
Keyword(s):  
Water Intake ◽  
Elevated Temperatures ◽  
Plasma Corticosterone ◽  
Male Rats ◽  
Controlled Environment ◽  
Physiological Changes ◽  
Evaporative Water ◽  
Initial Exposure ◽  
Direct Exposure ◽  
Food And Water Intake

The physiological changes in male rats during acclimation were studied following direct or stepwise exposure to heat (32.5 degrees C) in a controlled-environment room. The animals were exposed to each temperature for 10 days beginning at 24.5 degrees C and returning to 24.5 degrees C in the reverse order of initial exposure. Relative humidity of 50 +/- 2% and a 12-h light-dark photoperiod (light from 0900 to 2100 h) were maintained. Physiological changes in metabolic rate (MR), evaporative water loss (EWL), plasma corticosterone, body water turnover, and food and water intake were measured. The results indicate a significantly (P less than 0.001) elevated plasma corticosterone and MR in rats exposed directly to heat from control temperature (24.5 degrees C) but not in those animals exposed stepwise via 29.0 degrees C. All kinetic parameters of water pool changed (P less than 0.01) on direct exposure to heat, whereas rats exposed in a stepwise manner increased only pool turnover. In addition, exposure to experimental temperatures resulted in reduced (P less than 0.05) relative food intake and increased (P less than 0.05) water intake. Compared with the control condition of 24.5 degrees C, EWL was significantly (P less than 0.05) elevated when the animals were exposed either directly or in a stepwise fashion to 32.5 degrees C. These data suggest that the response to elevated temperatures is influenced by the temperature to which the rat is acclimated.

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