Food and water intake in rats with parasagittal knife cuts medial or lateral to the lateral hypothalamus.

1971 ◽  
Vol 74 (1, Pt.1) ◽  
pp. 148-156 ◽  
Author(s):  
Sebastian P. Grossman ◽  
Lore Grossman
Keyword(s):  
Water Intake ◽  
Lateral Hypothalamus ◽  
Food And Water Intake

Localization of Lesions in the Lateral Hypothalamus of Rats With Induced Adipsia and Aphagia

1958 ◽  
Vol 193 (1) ◽  
pp. 230-234 ◽  
Author(s):  
Seoras D. Morrison ◽  
Russell J. Barrnett ◽  
Jean Mayer
Keyword(s):  
Water Intake ◽  
Lateral Hypothalamus ◽  
Detailed Examination ◽  
Sham Operation ◽  
Median Forebrain Bundle ◽  
Lateral Hypothalamic ◽  
Stereotaxic Instrument ◽  
Electrolytic Lesions ◽  
Food And Water Intake ◽  
Lateral Area

A detailed examination was made of the areas damaged in animals exhibiting aphagia and adipsia following electrolytic lesions placed in the lateral hypothalamic and sub-thalamic areas with the use of a stereotaxic instrument. This study strongly suggests that the median forebrain bundle may be as important as the lateral area proper in the control of food and water intake. A similar conclusion is also suggested by the localization of areas of destruction in the midbrain of animals showing prolonged aphagia and adipsia following a ‘sham operation’ involving placement of needle electrodes without passage of current.

Alterations in food and water intake after hypothalamic lesions in the rat

1962 ◽  
Vol 203 (2) ◽  
pp. 366-370 ◽  
Author(s):  
Roland W. Smith ◽  
S. M. McCann
Keyword(s):  
Weight Loss ◽  
Food Intake ◽  
Diabetes Insipidus ◽  
Water Intake ◽  
Lateral Hypothalamus ◽  
Group Water ◽  
Electrolytic Lesions ◽  
Food And Water Intake ◽  
The Difference ◽  
Observation Period

Electrolytic lesions in the lateral hypothalamus produced aphagia and adipsia. One rat remained adipsic until sacrifice 283 days after operation; 11 rats with lesions continued to drink water while refusing ground laboratory chow. This effect lasted until sacrifice, 8–13 days postlesions, suggesting that areas regulating water and food intake are separable. Lesions designed to induce diabetes insipidus were produced in rats in which variable renal water loss had been eliminated by prior nephrectomy. Rats with lesions drank significantly more than nephrectomized controls during the 2-day observation period. The experiment was repeated, but food was withheld and controls were subjected to sham hypothalamic operation. In this group water intake was greater and weight loss less in rats with lesions than in sham-operated controls, though the difference was less than that in the presence of food. Although the difference in water intake was small, the results suggest that destruction of an inhibitory drinking center may contribute to polydipsia in diabetes insipidus. Water intake may be stimulated by lateral and inhibited by medial areas in the hypothalamus.

Effect of cerebrocrast on body and organ weights, food and water intake, and urine output of normal rats

2008 ◽  
Vol 26 (8) ◽  
pp. 908-915 ◽  
Author(s):  
Janina Briede ◽  
Mara Stivrina ◽  
Dzintra Stoldere ◽  
Brigita Vigante ◽  
Gunars Duburs
Keyword(s):  
Water Intake ◽  
Urine Output ◽  
Organ Weights ◽  
Food And Water Intake

scholarly journals Involvement of Central β-Adrenergic Circuitry in Food and Water Intake in Chickens

2015 ◽  
Vol 47 (2) ◽  
pp. 128-132 ◽  
Author(s):  
A. Baghbanzadeh ◽  
Z. Hamidiya ◽  
M. H. Geranmayeh
Keyword(s):  
Water Intake ◽  
Food And Water Intake

Acclimation of rats following stepwise or direct exposure to heat

1985 ◽  
Vol 59 (2) ◽  
pp. 408-412 ◽  
Author(s):  
A. R. Gwosdow ◽  
E. L. Besch ◽  
C. L. Chen
Keyword(s):  
Water Intake ◽  
Elevated Temperatures ◽  
Plasma Corticosterone ◽  
Male Rats ◽  
Controlled Environment ◽  
Physiological Changes ◽  
Evaporative Water ◽  
Initial Exposure ◽  
Direct Exposure ◽  
Food And Water Intake

The physiological changes in male rats during acclimation were studied following direct or stepwise exposure to heat (32.5 degrees C) in a controlled-environment room. The animals were exposed to each temperature for 10 days beginning at 24.5 degrees C and returning to 24.5 degrees C in the reverse order of initial exposure. Relative humidity of 50 +/- 2% and a 12-h light-dark photoperiod (light from 0900 to 2100 h) were maintained. Physiological changes in metabolic rate (MR), evaporative water loss (EWL), plasma corticosterone, body water turnover, and food and water intake were measured. The results indicate a significantly (P less than 0.001) elevated plasma corticosterone and MR in rats exposed directly to heat from control temperature (24.5 degrees C) but not in those animals exposed stepwise via 29.0 degrees C. All kinetic parameters of water pool changed (P less than 0.01) on direct exposure to heat, whereas rats exposed in a stepwise manner increased only pool turnover. In addition, exposure to experimental temperatures resulted in reduced (P less than 0.05) relative food intake and increased (P less than 0.05) water intake. Compared with the control condition of 24.5 degrees C, EWL was significantly (P less than 0.05) elevated when the animals were exposed either directly or in a stepwise fashion to 32.5 degrees C. These data suggest that the response to elevated temperatures is influenced by the temperature to which the rat is acclimated.

Role of lateral hypothalamus on fluid, electrolyte, and cardiovascular responses to activation of the MSA

1994 ◽  
Vol 266 (2) ◽  
pp. R496-R502 ◽  
Author(s):  
A. S. Haibara ◽  
W. A. Saad ◽  
J. V. Menani ◽  
L. A. Camargo ◽  
A. Renzi
Keyword(s):  
Water Intake ◽  
Lateral Hypothalamus ◽  
Cardiovascular Responses ◽  
Electrolytic Lesion ◽  
Opioid Agonist ◽  
Inhibitory Mechanisms ◽  
Pressor Responses ◽  
Medial Septal Area ◽  
Opiate Agonist

In this study we investigated the influence of electrolytic lesion or of opioid agonist injections into the lateral hypothalamus (LH) on the dipsogenic, natriuretic, kaliuretic, antidiuretic, pressor, and bradycardiac effects of cholinergic stimulation of the medial septal area (MSA) in rats. Sham- and LH-lesioned male Holtzman rats received a stainless steel cannula implanted into the LH. Other groups of rats had cannulas implanted simultaneously into the MSA and LH. Carbachol (2 nmol) injection into the MSA induced water intake, pressor, and bradycardic responses. LH lesion reduced all of these effects (1-3 and 15-18 days). Previous injection of synthetic opiate agonist, FK-33824 (100 ng), into the LH reduced the water intake, natriuresis, kaliuresis, and pressor responses induced by carbachol injected into the MSA. These data show that both electrolytic lesion or injection of an opiate agonist in the LH reduces the fluid-electrolyte and cardiovascular responses to cholinergic activation of the MSA. The involvement of LH with central excitatory and inhibitory mechanisms related to fluid-electrolytic and cardiovascular control is suggested.

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