Social hierarchy regulates ocular dominance plasticity in adult male mice

ABSTRACTWe here show that social rank, as assessed by competition for a running wheel, influences ocular dominance plasticity in adult male mice. Dominant animals showed a clear ocular dominance shift after four days of MD, whereas their submissive cage mates did not. NMDA receptor activation, reduced GABA inhibition, and serotonin transmission were necessary for this plasticity, but not sufficient to explain the difference between dominant and submissive animals. In contrast, prefrontal dopamine concentration was higher in dominant than submissive mice, and systemic manipulation of dopamine transmission bidirectionally changed ocular dominance plasticity. Thus, we could show that a social hierarchical relationship influences ocular dominance plasticity in the visual cortex via higher-order cortices, most likely the medial prefrontal cortex. Further studies will be needed to elucidate the precise mechanisms by which this regulation takes place.

Download Full-text

Social hierarchy regulates ocular dominance plasticity in adult male mice

Brain Structure and Function ◽

10.1007/s00429-019-01959-w ◽

2019 ◽

Vol 224 (9) ◽

pp. 3183-3199

Author(s):

Jenny Balog ◽

Franziska Hintz ◽

Marcel Isstas ◽

Manuel Teichert ◽

Christine Winter ◽

...

Keyword(s):

Adult Male ◽

Ocular Dominance ◽

Social Hierarchy ◽

Male Mice ◽

Ocular Dominance Plasticity

Download Full-text

Social experience modulates ocular dominance plasticity differentially in adult male and female mice

NeuroImage ◽

10.1016/j.neuroimage.2014.08.040 ◽

2014 ◽

Vol 103 ◽

pp. 454-461 ◽

Cited By ~ 9

Author(s):

Jenny Balog ◽

Ulrike Matthies ◽

Lisa Naumann ◽

Mareike Voget ◽

Christine Winter ◽

...

Keyword(s):

Adult Male ◽

Ocular Dominance ◽

Social Experience ◽

Ocular Dominance Plasticity ◽

Male And Female ◽

Female Mice

Download Full-text

Differential effects on bone of estrogen receptor and androgen receptor activation in orchidectomized adult male mice

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.2233084100 ◽

2003 ◽

Vol 100 (23) ◽

pp. 13573-13578 ◽

Cited By ~ 87

Author(s):

S. Moverare ◽

K. Venken ◽

A.-L. Eriksson ◽

N. Andersson ◽

S. Skrtic ◽

...

Keyword(s):

Estrogen Receptor ◽

Androgen Receptor ◽

Adult Male ◽

Receptor Activation ◽

Male Mice ◽

Differential Effects ◽

Androgen Receptor Activation

Download Full-text

Ablation of Cerebellar Golgi Cells Disrupts Synaptic Integration Involving GABA Inhibition and NMDA Receptor Activation in Motor Coordination

Cell ◽

10.1016/s0092-8674(00)81779-1 ◽

1998 ◽

Vol 95 (1) ◽

pp. 17-27 ◽

Cited By ~ 138

Author(s):

Dai Watanabe ◽

Hitoshi Inokawa ◽

Kouichi Hashimoto ◽

Norimitsu Suzuki ◽

Masanobu Kano ◽

...

Keyword(s):

Nmda Receptor ◽

Motor Coordination ◽

Receptor Activation ◽

Synaptic Integration ◽

Golgi Cells ◽

Gaba Inhibition ◽

Nmda Receptor Activation

Download Full-text

Exercise does not enhance short-term deprivation-induced ocular dominance plasticity: evidence from dichoptic surround suppression

10.1101/2020.10.07.329896 ◽

2020 ◽

Author(s):

Alex S Baldwin ◽

Hayden M Green ◽

Abigail E Finn ◽

Nicholas Gant ◽

Robert F Hess

Keyword(s):

Meta Analysis ◽

Ocular Dominance ◽

Relative Strength ◽

Monocular Deprivation ◽

Sinusoidal Grating ◽

Surround Suppression ◽

Ocular Dominance Plasticity ◽

Exercise Condition ◽

Before And After ◽

The Difference

AbstractThe input from the two eyes is combined in the brain. In this combination, the relative strength of the input from each eye is determined by the ocular dominance. Recent work has shown that this dominance can be temporarily shifted. Covering one eye with an eye patch for a few hours makes its contribution stronger. It has been proposed that this shift can be enhanced by exercise. Here, we test this hypothesis using a dichoptic surround suppression task, and with exercise performed according to American College of Sport Medicine guidelines. We measured detection thresholds for patches of sinusoidal grating shown to one eye. When an annular mask grating was shown simultaneously to the other eye, thresholds were elevated. The difference in the elevation found in each eye is our measure of relative eye dominance. We made these measurements before and after 120 minutes of monocular deprivation (with an eye patch). In the control condition, subjects rested during this time. For the exercise condition, 30 minutes of exercise were performed at the beginning of the patching period. This was followed by 90 minutes of rest. We find that patching results in a shift in ocular dominance that can be measured using dichoptic surround suppression. However, we find no effect of exercise on the magnitude of this shift. We further performed a meta-analysis on the four studies that have examined the effects of exercise on the dominance shift. Looking across these studies, we find no evidence for such an effect.

Download Full-text

Layer differences in the effect of monocular vision in light- and dark-reared kittens

Visual Neuroscience ◽

10.1017/s0952523801185147 ◽

2001 ◽

Vol 18 (5) ◽

pp. 811-820 ◽

Cited By ~ 20

Author(s):

CHRISTOPHER J. BEAVER ◽

QINGHUA JI ◽

NIGEL W. DAW

Keyword(s):

Visual Cortex ◽

Critical Period ◽

Ocular Dominance ◽

Large Change ◽

Monocular Deprivation ◽

Monocular Vision ◽

Ocular Dominance Plasticity ◽

The Difference ◽

Dark Rearing

We compared the effect of 2 days of monocular vision on the ocular dominance of cells in the visual cortex of light-reared kittens with the effect in dark-reared kittens at 6, 9, and 14 weeks of age, and analyzed the results by layer. The size of the ocular-dominance shift declined with age in all layers in light-reared animals. There was not a large change in the ocular-dominance shift with age in dark-reared animals in any layer, suggesting that dark rearing largely keeps the cortex in the immature 6-week state until 14 weeks or longer, although there was a slight decrease in layers II, III, and IV, and a slight increase in layers V and VI. At 14 weeks, the difference between light- and dark-reared animals was smallest in layer IV, larger in layers II/III, and largest in layers V/VI, suggesting that dark rearing has a large effect on intracortical synapses and a small effect on geniculocortical synapses. There was a significant ocular-dominance shift in layer IV at 14 weeks of age in both light- animals and dark-reared animals, showing that the critical period for ocular-dominance plasticity is not ended at this age. While the ocular-dominance shift after 26 h of monocular deprivation in 6-week animals was similar in light- and dark-reared animals, after 14 h it was smaller in dark-reared animals, showing that ocular-dominance changes occur more slowly in dark-reared animals at this age, in agreement with Mower (1991). Increases in selectivity for axis of movement after 26 h of monocular vision were seen in dark-reared animals at 6 weeks of age, but not at 9 or 14 weeks of age, showing that the critical period for axial selectivity ends earlier than the critical period for ocular dominance in dark-reared animals, as it does in light-reared animals.

Download Full-text