A New Class of Arabidopsis Mutants with Reduced Hexadecatrienoic Acid Fatty Acid Levels

Sirtuins (SIRT), first discovered in yeast as NAD+ dependent epigenetic and metabolic regulators, have comparable activities in human physiology and disease. Mounting evidence supports that the seven-member mammalian sirtuin family (SIRT1–7) guard homeostasis by sensing bioenergy needs and responding by making alterations in the cell nutrients. Sirtuins play a critical role in restoring homeostasis during stress responses. Inflammation is designed to “defend and mend” against the invading organisms. Emerging evidence supports that metabolism and bioenergy reprogramming direct the sequential course of inflammation; failure of homeostasis retrieval results in many chronic and acute inflammatory diseases. Anabolic glycolysis quickly induced (compared to oxidative phosphorylation) for ROS and ATP generation is needed for immune activation to “defend” against invading microorganisms. Lipolysis/fatty acid oxidation, essential for cellular protection/hibernation and cell survival in order to “mend,” leads to immune repression. Acute/chronic inflammations are linked to altered glycolysis and fatty acid oxidation, at least in part, by NAD+ dependent function of sirtuins. Therapeutically targeting sirtuins may provide a new class of inflammation and immune regulators. This review discusses how sirtuins integrate metabolism, bioenergetics, and immunity during inflammation and how sirtuin-directed treatment improves outcome in chronic inflammatory diseases and in the extreme stress response of sepsis.

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State of the lipid and fatty acid composition in chloroplasts of Nicotiana tabacum under the influence of an increased CO2 partial pressure of 700 p.p.m.

Biochemical Society Transactions ◽

10.1042/bst0280885 ◽

2000 ◽

Vol 28 (6) ◽

pp. 885-887 ◽

Cited By ~ 3

Author(s):

A. Radunz ◽

K. Alfermann ◽

G. H. Schmid

Keyword(s):

Fatty Acids ◽

Fatty Acid Composition ◽

Fatty Acid ◽

Nicotiana Tabacum ◽

Palmitic Acid ◽

Partial Pressure ◽

Carotenoid Content ◽

Saturation Degree ◽

Co2 Partial Pressure ◽

Hexadecatrienoic Acid

We analysed chloroplast lipids of Nicotiana tabacum var. John William's Broadleaf, cultivated under an increased Pco2 of 700 p.p.m. Glycolipids and phospholipids remain constant under these conditions, whereas the carotenoid content undergoes a quantitative change. The saturation degree of fatty acids increases due to an increase in palmitic acid and decreases in hexadecatrienoic acid and linolenic acid.

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Effects of 2-(3-Methyl-cinnamyl-hydrazono)-propionate on Fatty Acid and Glucose Oxidation in the Isolated Rat Diaphragm Using 14C-Labelled Substrates. Hydrazonopropionic Acids, a New Class of Hypoglycaemic Substances, VIII

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm.1988.26.12.815 ◽

1988 ◽

Vol 26 (12) ◽

Author(s):

L. Binder ◽

M. Oellerich ◽

R. Haeckel ◽

M. Beneking

Keyword(s):

Fatty Acid ◽

Glucose Oxidation ◽

Rat Diaphragm ◽

New Class ◽

Isolated Rat

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Arabidopsis mutants of sphingolipid fatty acid α-hydroxylases accumulate ceramides and salicylates

New Phytologist ◽

10.1111/j.1469-8137.2012.04351.x ◽

2012 ◽

Vol 196 (4) ◽

pp. 1086-1097 ◽

Cited By ~ 39

Author(s):

Stefanie König ◽

Kirstin Feussner ◽

Marnie Schwarz ◽

Alexander Kaever ◽

Tim Iven ◽

...

Keyword(s):

Fatty Acid ◽

Arabidopsis Mutants

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Camel Milk Disguised Cosmeceutical

Handbook of Research on Health and Environmental Benefits of Camel Products - Practice, Progress, and Proficiency in Sustainability ◽

10.4018/978-1-7998-1604-1.ch016 ◽

2020 ◽

pp. 348-362

Author(s):

Rajesh Datt Mehta ◽

Ritika Agrawal

Keyword(s):

Ascorbic Acid ◽

Fatty Acid ◽

Polyunsaturated Fatty Acid ◽

Hydroxy Acid ◽

Cost Effective ◽

Camel Milk ◽

New Class ◽

Systemic Reactions ◽

Bioactive Ingredients ◽

Aging Skin

This chapter conveys the untapped property of camel milk as cosmeceutical. The camel milk ingredients (i.e., water, ascorbic acid, alpha hydroxy acid, polyunsaturated fatty acid, peptides, and micronutrients) make it a cost-effective cosmeceutical with no adverse cutaneous or systemic reactions. It may be used as a photoprotective, moisturizing, anti-wrinkle, anti-aging skin softener. The bioactive ingredients may begin the new class of natural cosmeceutical when consumed orally or applied topically.

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