Global Transcriptome Profiling of Developing Leaf and Shoot Apices Reveals Distinct Genetic and Environmental Control of Floral Transition and Inflorescence Development in Barley

Hematopoietic stem cells (HSCs) are maintained through the regulation of symmetric and asymmetric cell division. We report that conditional ablation of the RNA-binding protein Msi2 results in a failure of HSC maintenance and engraftment caused by a loss of quiescence and increased commitment divisions. Contrary to previous studies, we found that these phenotypes were independent of Numb. Global transcriptome profiling and RNA target analysis uncovered Msi2 interactions at multiple nodes within pathways that govern RNA translation, stem cell function, and TGF-β signaling. Msi2-null HSCs are insensitive to TGF-β–mediated expansion and have decreased signaling output, resulting in a loss of myeloid-restricted HSCs and myeloid reconstitution. Thus, Msi2 is an important regulator of the HSC translatome and balances HSC homeostasis and lineage bias.

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Global transcriptome profiling identifies KLF15 and SLC25A10 as modifiers of adipocytes insulin sensitivity in obese women

PLoS ONE ◽

10.1371/journal.pone.0178485 ◽

2017 ◽

Vol 12 (6) ◽

pp. e0178485 ◽

Cited By ~ 9

Author(s):

Agné Kulyté ◽

Anna Ehrlund ◽

Peter Arner ◽

Ingrid Dahlman

Keyword(s):

Insulin Sensitivity ◽

Transcriptome Profiling ◽

Obese Women ◽

Global Transcriptome

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Global Transcriptome Profiling of Genes that Are Differentially Regulated During Differentiation of Mouse Embryonic Neural Stem Cells into Astrocytes

Journal of Molecular Neuroscience ◽

10.1007/s12031-014-0382-8 ◽

2014 ◽

Vol 55 (1) ◽

pp. 109-125 ◽

Cited By ~ 8

Author(s):

Dalmuri Han ◽

Mi Ran Choi ◽

Kyoung Hwa Jung ◽

Namshin Kim ◽

Se kye Kim ◽

...

Keyword(s):

Stem Cells ◽

Neural Stem Cells ◽

Transcriptome Profiling ◽

Global Transcriptome

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Artemisinin mimics calorie restriction to extend yeast lifespan via a dual-phase mode: a conclusion drawn from global transcriptome profiling

Science China Life Sciences ◽

10.1007/s11427-014-4736-9 ◽

2015 ◽

Vol 58 (5) ◽

pp. 451-465 ◽

Cited By ~ 7

Author(s):

DaTing Wang ◽

Ming Wu ◽

SiMing Li ◽

Qian Gao ◽

QingPing Zeng

Keyword(s):

Calorie Restriction ◽

Transcriptome Profiling ◽

Dual Phase ◽

Global Transcriptome ◽

Mode A

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Vegetative and reproductive development of shoot apices of Pharbitis nil as influenced by photoperiodism

Canadian Journal of Botany ◽

10.1139/b69-200 ◽

1969 ◽

Vol 47 (9) ◽

pp. 1403-1406 ◽

Cited By ~ 6

Author(s):

D. S. Bhar ◽

N. W. Radforth

Keyword(s):

Mitotic Activity ◽

Dark Period ◽

Pollen Grains ◽

Reproductive Development ◽

Epidermal Cells ◽

Floral Transition ◽

Pharbitis Nil ◽

Shoot Apices ◽

The Third

In shoot apices of Pharbitis nil, cytohistological zonation is not clearly delineated at germination. With increase in age, zonation develops and the granular appearance of the cytoplasm disappears. After induction by a single 16-hour dark period the first recognizable sign of floral transition becomes evident on the second day, with increase in the mitotic activity of the apex. On the third and fourth days, the sepals are initiated and the petals and stamens are initiated simultaneously on the fifth day. On the sixth day the carpel primordia originate. Between the 11th and 12th days after the inductive dark period, the pollen grains develop and the style extends. Between the 19th and 20th days the epidermal cells of the stigma become secretory.

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