scholarly journals A new experimental setup for high-throughput controlled non-photochemical laser-induced nucleation: application to glycine crystallization

2014 ◽  
Vol 47 (4) ◽  
pp. 1252-1260 ◽  
Author(s):  
Bertrand Clair ◽  
Aziza Ikni ◽  
Wenjing Li ◽  
Philippe Scouflaire ◽  
Vincent Quemener ◽  
...  

Non-photochemical laser-induced nucleation (NPLIN) has been a growing field of study since 1996, and more than 40 compounds including organics, inorganics and proteins have now been probed under various conditions (solvents, laser types, laser beamsetc.). The potential advantages of using this technique are significant, in particular polymorphic control. To realize these benefits, the objective is a carefully designed experimental setup and highly controlled parameters, for example temperature and energy density, in order to reduce the uncertainty regarding the origin of nucleation. In this paper, a new experimental setup designed to study NPLIN is reported. After a full technical description of the present setup, the different functionalities of this device will be illustrated through results on glycine. Glycine crystals obtained through NPLIN nucleate at the meniscus and exhibit different morphologies. The nucleation efficiency, as a function of the supersaturation of the solution used and the laser beam energy density, has also been established for a large number of samples, with all other parameters held constant.

2014 ◽  
Vol 32 (2) ◽  
pp. 311-319 ◽  
Author(s):  
A.I. Pushkarev ◽  
Yu.I. Isakova ◽  
I.P. Khaylov

AbstractThis paper presents the results of a statistical and correlation analysis of the energy and energy density of an ion beam formed by a self-magnetically insulated diode with an explosive emission cathode. The experiments were carried out with the TEMP-4M accelerator operating in double-pulse mode: plasma formation occurs during the first pulse (negative polarity, 300–500 ns, 100–150 kV), and ion extraction and acceleration during the second pulse (positive polarity, 120 ns, 250–300 kV). Various arrangements of diodes have been investigated: strip focusing and planar diodes, a conical focusing diode and a spiral diode. The total ion beam energy was measured using both a calorimeter and an infrared camera and the beam energy density was measured by the thermal imaging and acoustic diagnostics. The correlation analysis showed that ion current density is only weakly dependent on the accelerating voltage and other output parameters of the accelerator, with the coefficient of determination <0.3. At the same time, in this paper, we have identified that the total energy of the beam and the energy density is strongly dependant on the accelerator output parameters, since the coefficient of determination >0.9. The mechanism governing stabilization of the beam energy density from shot to shot was discovered and attributed to formation of the neutral component in ion beam as being due to charge exchange between accelerated ions and neutral molecules from a neutral layer near the anode surface. Implementation using a self-magnetically insulated diode with an explosive-emission cathode, having an operational lifetime of up to 106 shots, has promising prospects for various technological applications.


2007 ◽  
Vol 1059 ◽  
Author(s):  
Kensuke Nishioka ◽  
Susumu Horita

ABSTRACTPeriodic arrays of nano-sized Si and Ni dots were fabricated by only irradiating a linearly polarized Nd:YAG pulsed laser beam to Si and Ni thin films deposited on silicon dioxide (SiO2) film. The interference between an incident beam and a scattered surface wave leads to the spatial periodicity of beam energy density distribution on the surface of the irradiated samples. A thin film was melted using a laser beam, and the molten film was split and condensed owing to its surface tensile according to the periodic energy density distribution. Then, the fine lines (line and space structure) were formed periodically. After the formation of fine lines, the sample was rotated by 90°, and the laser beam was irradiated. The periodic energy density distribution was generated on the fine lines, and the lines split and condensed according to the periodic energy density distribution. Eventually, the periodically aligned nano-sized dots were fabricated on the SiO2 film.


2021 ◽  
pp. 71-78
Author(s):  
Sergei Kurashkin ◽  
Vadim Tynchenko ◽  
Yuriy Seregin ◽  
Aleksandr Murygin ◽  
Aleksey Bocharov

2021 ◽  
Vol 32 (12) ◽  
Author(s):  
Zhe Duan ◽  
Jin-Hui Chen ◽  
Hua Shi ◽  
Guang-Yi Tang ◽  
Lei Wang ◽  
...  

AbstractThe High Energy Photon Source (HEPS) is a 6 GeV diffraction-limited storage ring light source under construction. The swap-out injection is adopted with the depleted bunch recycled via high-energy accumulation in the booster. The extremely high beam energy density of the bunches with an ultra-low emittance (about 30 pm horizontally and 3 pm vertically) and high bunch charges (from 1.33 to 14.4 nC) extracted from the storage ring could cause hazardous damage to the extraction Lambertson magnet in case of extraction kicker failure. To this end, we proposed the use of a pre-kicker to spoil the bunches prior to extraction, significantly reducing the maximum beam energy density down to within a safe region while still maintaining highly efficient extractions. The main parameters of the pre-kicker are simulated and discussed.


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