60 Background: Trust influences health care through the willingness to seek and continue care, disclose sensitive information, adhere to treatment, and satisfaction with care. In a recent prospective study of patient perception of physician compassion, the degree of trust in the medical profession was found to be significantly associated with higher perception of compassion. In this secondary analysis, we explored the association between trust and other demographic and psychosocial factors. We also explored the performance of the single item Degree of Trust scale compared to the validated 5-item Trust in Medical Profession scale. Methods: A secondary analysis of prospectively collected data was performed. Trust scores completed by 100 patients were correlated with age, gender, ethnicity, educational level, anxiety, depression, hopefulness, and a 0 (best) – 10 (worst) Degree of Trust question. Results: Scores were 13, 11-14 [median, IQR; inversely scored] for Trust in Medical Profession and 2, 1-4 [median, IQR] for Degree of Trust with moderate correlation [r = 0.587, p < 0.001]. On evaluating performance of Degree of Trust scale to the validated Trust in Medical Profession scale, a moderately high performance was found [Youden’s J = 0.73; Topleft = 0.21]. Older age [57, 49-65 (median, IQR), p = 0.02] lower depression scores [6,3-9 (median, IQR), p < 0.01] and more hopefulness [22,20-25 (median, IQR), p = 0.01] were associated with higher levels of trust. Conclusions: Trust was associated with older age, less depressed and more hopeful patients. A single 0-10 item trust scale was found to perform adequately compared to a multiple item questionnaire.